The sheet-to-helix transition is a potential gas-phase unfolding pathway for a multidomain protein CRM197 [0.03%]
由多结构域蛋白CRM197的片层到螺旋的转化是一种潜在的气相展開路径
Xia Xu,Guiqian Yang,Zhen Zheng et al.
Xia Xu et al.
Despite the expansive applications of gas-phase unfolding techniques, the molecular mechanism for the solvent-free forced unfolding pathway which substrate multidomain proteins usually adopt remains elusive at the secondary structure level....
Synthesis and Characterization of Fluorescence Active G4-Quartet and Direct Evaluation of Self-Assembly Impact on Emission [0.03%]
发光G4四聚体的合成、表征及自组装对其荧光性质的影响研究
Ying He,Mengjia Liu,Shun Teng et al.
Ying He et al.
Fluorescence (FL) active 8-aryl guanosine derivatives were prepared and applied for cation mediated self-assembly to form the H-bonded G8-quadruplexes. The p-cyano (p-CN) and 8-anthracene (8-An) substituted guanosines were identified to giv...
Three-dimensional heterogeneous electro-Fenton system with reduced graphene oxide based particle electrode for Acyclovir removal [0.03%]
基于还原氧化石墨烯的粒子电极三维异质电芬顿系统去除阿昔洛韦
Nan Cai,Ge Bai,Ting Zhang et al.
Nan Cai et al.
New pollutant pharmaceutical and personal care products (PPCPs), especially antiviral drugs, have received increasing attention not only due to their increase in usage after the outbreak of COVID-19 epidemics but also due to their adverse i...
Recent progress on rapid diagnosis of COVID-19 by point-of-care testing platforms [0.03%]
基于即时检测平台的COVID-19快速诊断最新进展
Ya-Nan Tang,Dingding Jiang,Xuejun Wang et al.
Ya-Nan Tang et al.
The outbreak of COVID-19 has drawn great attention around the world. SARS-CoV-2 is a highly infectious virus with occult transmission by many mutations and a long incubation period. In particular, the emergence of asymptomatic infections ha...
Research progress of severe acute respiratory syndrome coronavirus 2 on aerosol collection and detection [0.03%]
气溶胶采集与检测中新型冠状病毒的研究进展
Xinyu Zhang,Yuting Chen,Yueying Pan et al.
Xinyu Zhang et al.
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019 has negatively affected people's lives and productivity. Because the mode of transmission of SARS-CoV-2 is of great concern, this review discusses the...
Programmable endonuclease combined with isothermal polymerase amplification to selectively enrich for rare mutant allele fractions [0.03%]
结合等温聚合酶放大选择性富集稀有突变等位基因分数的可编程内切核酸酶
Junman Chen,Tian Qiud,Michael G Mauk et al.
Junman Chen et al.
Liquid biopsy is a highly promising method for non-invasive detection of tumor-associated nucleic acid fragments in body fluids but is challenged by the low abundance of nucleic acids of clinical interest and their sequence homology with th...
Novel aerosol detection platform for SARS‑CoV‑2: Based on specific magnetic nanoparticles adsorption sampling and digital droplet PCR detection [0.03%]
基于特异性磁纳米颗粒吸附采样和数字微滴PCR检测的新型气溶胶检测平台用于SARS-CoV-2
Hui Chen,Xinye Ma,Xinyu Zhang et al.
Hui Chen et al.
The SARS‑CoV‑2 virus is released from an infectious source (such as a sick person) and adsorbed on aerosols, which can form pathogenic microorganism aerosols, which can affect human health through airborne transmission. Efficient sampling...
Nanokit coupled electrospray ionization mass spectrometry for analysis of angiotensin converting enzyme 2 activity in single living cell [0.03%]
单细胞水平血管紧张素转换酶活性分析的纳米套耦合电喷雾质谱法
Xinqi Chang,Nina Wang,Depeng Jiang et al.
Xinqi Chang et al.
Angiotensin-converting enzyme 2 (ACE2) is not only an enzyme but also a functional receptor on cell membrane for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, the activity of ACE2 in single living cell is firstly deter...
The role of CuI in the siloxane-mediated Pd-catalyzed cross-coupling reactions of aryl iodides with aryl lithium reagents [0.03%]
CuI在硅氧烷介导的Pd催化芳基碘与芳基锂试剂交叉偶联反应中的作用研究
Yu Chen,Xiao Zhang,Fang Liu et al.
Yu Chen et al.
Experiments indicate that a catalytic amount of CuI plays an important role in the siloxane-mediated Pd-catalyzed cross-coupling reactions with the direct use of organolithium reagents. Addition of organolithium to the siloxane transfer age...
Reviving chloroquine for anti-SARS-CoV-2 treatment with cucurbit[7]uril-based supramolecular formulation [0.03%]
基于葫芦脲的超分子制剂重振氯喹抗SARS-CoV-2治疗功效
Cheryl H T Kwong,Jingfang Mu,Shengke Li et al.
Cheryl H T Kwong et al.
The wide-spreading SARS-CoV-2 virus has put the world into boiling water for more than a year, however pharmacological therapies to act effectively against coronavirus disease 2019 (COVID-19) remain elusive. Chloroquine (CQ), an antimalaria...