Immune cell metabolism in cancer drug resistance: Advances in target discovery and clinical translation [0.03%]
肿瘤药理抵抗中的免疫细胞代谢：目标发现及临床转化的新进展
Liangjie Sun,Guo Zhao,Shuhang Wang et al.
Liangjie Sun et al.
Drug resistance continues to be the principal limiting factor in achieving a cure for patients with cancer, significantly hindering the long-term efficacy of novel cancer drugs. Accumulating evidence has shown that metabolites derived from ...
Venetoclax and azacitidine compared with intensive chemotherapy for adverse-risk acute myeloid leukemia patients receiving allogeneic hematopoietic stem cell transplantation in first complete remission: A multicenter study of TROPHY group [0.03%]
用于高危急性髓系白血病患者首次完全缓解后异基因造血干细胞移植的诱导方案比较：TROPHY研究小组的一项多中心研究
Qi Wen,Chuanhe Jiang,Xiaodan Liu et al.
Qi Wen et al.
Objective: Adverse-risk acute myeloid leukemia (AML) patients should receive allogeneic hematopoietic stem cell transplantation (allo-HSCT) at first complete remission (CR1). However, the influence of prior therapies [i.e...
Long-term outcomes of laparoscopic distal gastrectomy for locally advanced gastric cancer: An individual patient data meta-analysis of KLASS-02 and CLASS-01 randomized controlled trials [0.03%]
腹腔镜远端胃切除治疗局部进展期胃癌的长期疗效：KLASS-02和CLASS-01随机对照试验的个体患者数据meta分析
Yanfeng Hu,Woo Jin Hyung,Huilin Huang et al.
Yanfeng Hu et al.
Objective: Laparoscopic distal gastrectomy (LDG) has potential as a surgical treatment option for locally advanced gastric cancer (LAGC). However, there is uncertainty regarding the generalizability of LDG efficacy across...
Evaluation of two algorithms measuring homologous recombination deficiency status in prognostic assessment for treatment-naïve non-small cell lung cancer [0.03%]
评估两种同源重组修复缺陷检测算法在初治非小细胞肺癌患者预后及免疫治疗疗效中的价值
Yidan Ma,Jingyu Huang,Lei He et al.
Yidan Ma et al.
Objective: Patients with homologous recombination deficiency (HRD) demonstrate distinct clinicopathological and prognostic features. However, standardised and clinically validated HRD detection methodologies specifically ...
Development and validation of machine learning-based survival analysis to predict outcome in gastric cancer with adjuvant chemotherapy: A multicenter, longitudinal, cohort study [0.03%]
基于机器学习的生存分析在胃癌辅助化疗结局预测中的发展和验证：一项多中心纵向队列研究
Yan Pan,Linbin Lu,Xianchun Gao et al.
Yan Pan et al.
Objective: The previously integrated tumor-inflammation-nutrition (HI-GC) score has demonstrated dynamic monitoring value for recurrence and clinical decision-making in patients with postsurgical gastric cancer (GC). Howe...
Deep learning-based differentiation of benign and malignant thyroid follicular neoplasms on multiscale intraoperative frozen pathological images: A multicenter diagnostic study [0.03%]
基于深度学习的多尺度术中冰冻病理图像鉴别甲状腺滤泡性肿瘤良恶性：一项多中心诊断研究
Jiahui Liu,Chuanguang Xiao,Haicheng Zhang et al.
Jiahui Liu et al.
Objective: This study aims to develop a deep multiscale image learning system (DMILS) to differentiate malignant from benign thyroid follicular neoplasms on multiscale whole-slide images (WSIs) of intraoperative frozen pa...
Demin Lu,Caixia Dong,Kailai Wang et al.
Demin Lu et al.
Potential impact of controlling risk factors on future liver cancer deaths in China [0.03%]
控制风险因素对中国未来肝癌死亡率的潜在影响
Mengdi Cao,Yi Teng,Qianru Li et al.
Mengdi Cao et al.
Objective: This study aims to quantify the potential impact of controlling major risk factors on liver cancer deaths in China from 2021 to 2050 under various intervention scenarios. ...
Comparison of efficacy and safety of a proposed biosimilar QL1206 with reference denosumab in patients with bone metastasis from breast cancer: A subgroup analysis of a randomized, double-blinded phase III study [0.03%]
一项随机双盲III期临床试验的亚组分析：拟生物药QL1206与抗骨质疏松参比药物denosumab在乳腺癌骨转移患者中的疗效及安全性比较研究
Yaxin Liu,Ruyan Zhang,Xiaojia Wang et al.
Yaxin Liu et al.
Objective: To evaluate the efficacy and safety of QL1206 (a denosumab biosimilar to Xgeva®) in breast cancer patients with bone metastasis (BM) through subgroup analysis of a randomized, double-blind phase III trial (No....
Multi-omics profile of exceptional long-term survivors of AJCC stage III triple-negative breast cancer [0.03%]
AJCC三期三阴性乳腺癌长期生存者多组学特征分析
Yang Ou-Yang,Caijin Lin,Yifan Xie et al.
Yang Ou-Yang et al.
Objective: Triple-negative breast cancer (TNBC) is a highly aggressive subtype that lacks targeted therapies, leading to a poorer prognosis. However, some patients achieve long-term recurrence-free survival (RFS), offerin...