Molecular subtypes and prognostic signature rooted in disulfidptosis highlight tumor microenvironment in lung adenocarcinoma [0.03%]
基于二硫化物诱导的分子亚型和预后标志突出肺癌微环境
Wei Xia,Jiwei Liu,Ruo Chen et al.
Wei Xia et al.
Objective: A highly aggressive and lethal malignancy, characterized by its heterogeneity, lung adenocarcinoma (LUAD) presents significant challenges in prognosis and treatment. Disulfidptosis, a newly identified form of r...
Plasma cell-free DNA methylation markers for detection and prognosis of gastric cancer: A case-control study [0.03%]
胃癌检测和预后的游离DNA甲基化标志物：病例对照研究
Yanan Wang,Longyang Jin,Weiyang He et al.
Yanan Wang et al.
Objective: Plasma cell-free DNA (cfDNA) methylation has shown potential in the detection and prognostic testing of multiple cancers. Here, we comprehensively investigate the performance of cfDNA methylation for gastric ca...
Haploidentical donor vs. human leukocyte antigen-matched donor hematopoietic cell transplantation for elderly patients with hematologic malignancies: Inferior non-relapse mortality but comparable survival [0.03%]
单倍型相合供者与人类白细胞抗原全合供者造血细胞移植对老年血液系统恶性肿瘤患者的非复发死亡率及生存率的影响：单倍型相合供者的非复发死亡率较高，但总生存率相当
Mengqi Xiang,Xiang Zhang,Mimi Xu et al.
Mengqi Xiang et al.
Impact of resection margin status on survival in gastric cancer: A retrospective cohort study [0.03%]
胃癌患者切缘状态对生存影响的队列研究
Whei Kyong Jung,Jane Chungyoon Kim,Hyun-Jae Lee et al.
Whei Kyong Jung et al.
Objective: Microscopically positive resection margins (R1) in gastric cancer have been associated with poor outcomes, but evidence regarding its prognostic significance across different stages remains inconsistent. This s...
Advances in integrating biomaterials with CAR-T cells for enhancing solid tumor therapy [0.03%]
用于增强实体瘤治疗的CAR-T细胞与生物材料整合研究进展
Shuting Huang,Yan Zhao,Jie Shen
Shuting Huang
Chimeric antigen receptor T (CAR-T) cell immunotherapy has emerged as a transformative modality in immuno-oncology. However, the clinical translation of CAR-T therapy for solid tumors remains significantly limited by physical barriers, an i...
Zhile Chen,Lin Li,Diange Jin et al.
Zhile Chen et al.
Acute graft-versus-host disease (aGVHD) is an important complication which critically impacts the prognosis of patients undergoing allogeneic hematopoietic stem cell transplantation. Increasing evidence suggests that dysbiosis of the gut mi...
Longitudinal variability of CT imaging features for predicting pulmonary nodule invasiveness: A multicenter study [0.03%]
一项多中心研究：基于CT影像特征的肺结节侵袭性的纵向变化规律
Jing Lu,Ci Song,Hai Xu et al.
Jing Lu et al.
Objective: This study aimed to construct a model that predicts invasive lung cancer using longitudinal radiological features from multiple low-dose computed tomography (LDCT) scans, thereby addressing overdiagnosis in lun...
HBV reactivation and its metabolomic profile after liver transplantation for hepatocellular carcinoma in non-alcoholic steatohepatitis [0.03%]
非酒精性肝炎患者肝移植后肝细胞癌的乙肝再激活及其代谢组学特征
Jinyan Chen,Leyi Chen,Huigang Li et al.
Jinyan Chen et al.
Objective: The role of non-alcoholic steatohepatitis (NASH) in hepatitis B virus (HBV) reactivation following liver transplantation for hepatocellular carcinoma (HCC) remains unclear, and the metabolic differences between...
Allogeneic transplantation in adverse-risk acute myeloid leukemia: Challenges, strategies, and future directions [0.03%]
高危急性髓系白血病异基因移植的挑战、策略和未来方向
Jingtao Huang,Xinyi Wu,Gaoxiang Wang et al.
Jingtao Huang et al.
Adverse-risk acute myeloid leukemia (AML) is a therapeutic challenge despite advances in risk stratification. Unmet needs persist in high-risk molecular subgroups, such as AML with myelodysplasia-related changes, TP53 mutations, or rearrang...
Can one scoring system fit all? Comparative validation of CAR-HEMATOTOX, ALL-HEMATOTOX, and eIPM for predicting immune effector cell-associated hematotoxicity following CAR-T therapy in hematologic malignancies [0.03%]
一种评分系统适合所有吗？比较验证CAR-HEMATOTOX、ALL-HEMATOTOX和eIPM在血液肿瘤CAR-T治疗后预测免疫效应细胞相关骨髓抑制的效能
Aoran Zhang,Hao Zheng,Qiannan Shang et al.
Aoran Zhang et al.
Objective: Immune effector cell-associated hematotoxicity (ICAHT), characterized by prolonged cytopenia and delayed hematopoietic recovery, is a common complication following chimeric antigen receptor T (CAR-T) cell thera...