Chromatin regulators TOP2A and PPARGC1A stratify prostate cancer risk and reveal TOP2A-driven progression via PI3K/AKT pathway [0.03%]
染色质调节因子TOP2A和PPARGC1A可对前列腺癌风险进行分类并揭示可通过PI3K / AKT通路发挥TOP2A驱动作用的进展期前列腺癌
Zhipeng Wang,Jie Wang,Shuang Chen et al.
Zhipeng Wang et al.
Objective: To identify chromatin regulators (CRs)-based molecular subtypes and risk scores for accurately predicting biochemical recurrence (BCR) after radical prostatectomy (RAP) in prostate cancer (PCa) patients. ...
Frontiers in bacterial outer membrane vesicles: From basic characteristics to cancer therapy [0.03%]
细菌外膜囊泡的基础特性及其在癌症治疗中的应用研究前沿
Siyang Ma,Jianxuan Sun,Jingyu Xu et al.
Siyang Ma et al.
Bacterial outer membrane vesicles (OMVs) are spherical nanostructures that originate from Gram-negative bacteria. They are gaining attention as powerful tools in cancer diagnostics and therapy due to their unique biological properties. Thes...
Dynamic income patterns and risk of pancreatic and biliary tract cancers: A nationwide cohort study [0.03%]
基于全国队列的胰腺癌和胆道癌发病模式及风险研究
Chung-Woo Lee,Kunhee Han,Yong-Moon Mark Park et al.
Chung-Woo Lee et al.
Objective: This study aimed to evaluate the associations of baseline income, cumulative income exposure, and income volatility with the incidence of pancreatic and biliary tract cancers in a nationwide Korean cohort. ...
Chemotherapy-free regimen: Real-world efficacy and safety of anlotinib plus PD-1/PD-L1 inhibitors in advanced non-small cell lung cancer [0.03%]
无化疗方案：安罗替尼联合PD-1/PD-L1抑制剂治疗晚期非小细胞肺癌的疗效和安全性研究
Haiyang Chen,Guanghua Yang,Tao Wang et al.
Haiyang Chen et al.
Objective: Chemotherapy-based regimens remain the standard first- and second-line treatment options for patients with driver gene-negative non-small cell lung cancer (NSCLC). However, in real-world settings, certain patie...
Expert consensus on multidisciplinary management of laparoscopic-endoscopic cooperative surgery combined with sentinel lymph node navigation surgery for early gastric cancer (2026 edition) [0.03%]
早期胃癌腹腔镜-内镜联合手术暨哨兵淋巴结导航手术多学科管理专家共识(2026版)
Zhi Zheng,Yu Zhao,Rui Xu et al.
Zhi Zheng et al.
With the advancement of surgical techniques and enhanced management of early gastric cancer (EGC), minimally invasive function-preserving surgical approaches have emerged as a common goal for patients and clinicians. Laparoscopic-endoscopic...
Circulating tumor cells with chromosome 8 aneuploidy are a diagnostic and prognostic monitoring biomarker for ovarian cancer [0.03%]
染色体8非整倍体系的循环肿瘤细胞是卵巢癌诊断和预后监测的生物标志物
Shimin Yang,Buyun Li,Hongyan Cheng et al.
Shimin Yang et al.
Objective: We investigated the clinical value of a novel circulating tumor cell (CTC) detection method-subtraction enrichment combined with immunostaining and fluorescence in situ hybridization (SE-iFISH)-in ovarian cance...
Evaluating diagnostic efficacy of multigene testing in non-diagnostic thyroid nodules by fine-needle aspiration cytology: A prospective cohort study [0.03%]
一项前瞻性队列研究：评估细针穿刺细胞学检查结果为诊断不明的甲状腺结节患者进行多基因检测的诊断效能
Guozhi Zhang,Lin Ren,Jia Xiao et al.
Guozhi Zhang et al.
Objective: Non-diagnostic thyroid nodules (Bethesda I) account for 5%-20% of all thyroid nodules. Accurate differentiation of benign and malignant nodules can reduce unnecessary surgeries and repeat biopsies. Herein we ev...
Metabolic reprogramming signature predicts immunotherapy efficacy in lung adenocarcinoma: Targeting SLC25A1 to overcome immune resistance [0.03%]
代谢重塑谱型预测肺癌免疫治疗疗效：靶向SLC25A1克服免疫抵抗
Pengpeng Zhang,Xiaoqing Liang,Bicheng Ye et al.
Pengpeng Zhang et al.
Objective: Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer. Despite significant advances in immunotherapy, treatment responses vary substantially among individuals. Metabolic reprogramming, as a hallm...
National Health Commission guidelines for diagnosis and treatment of colorectal cancer in China (2025 edition, English version) [0.03%]
中国结直肠癌诊疗规范（2025年版）
Department Of Medical Administration National Health Commission Of The People&#x;s Republic Of China Chinese Medical Association Oncology Branch
Department Of Medical Administration National Health Commission Of The People&#x;s Republic Of China Chinese Medical Association Oncology Branch
The National Health Commission of the People's Republic of China Guidelines for Diagnosis and Treatment of Colorectal Cancer (2025 edition), based on evidence-based medicine, integrates cutting-edge international advances with Chinese clini...