Discovery and validation of indole nitroolefins as novel covalent GPX4 inhibitors for inducing ferroptosis in urological cancers [0.03%]
尿路上皮肿瘤诱导铁死亡的小分子Gpx4新型共价抑制剂的设计合成与验证
Na Zeng,Guichen Ye,Mengchu Zheng et al.
Na Zeng et al.
Objective: Ferroptosis represents a form of cell death characterized by the accumulation of iron dependent lipid peroxidation. This process culminates in membrane damage and cell lysis. One pivotal surveillance mechanism ...
Tumor-educated cells in tumor microenvironment: Key drivers of immunotherapy resistance [0.03%]
肿瘤微环境中的肿瘤训练细胞：免疫疗法耐药的关键驱动因素
Ji&#x;an Zou,Shuxing Wang,Yingzhe Zhang et al.
Ji&#x;an Zou et al.
In the past decade, immunotherapies targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4), programmed cell death 1 (PD-1), and PD-1 ligand (PD-L1) have been approved for solid tumors. However, some patients demonstrate suboptimal clinical out...
Optimizing management of sentinel lymph node limited residual tumor after neoadjuvant therapy for breast cancer: Balancing of act [0.03%]
新辅助治疗后乳腺癌Sentinel淋巴结残余病灶的管理：行动平衡
Jing Sun,Zhiqiang Shi,Zhao Bi et al.
Jing Sun et al.
Optimal response population after neoadjuvant therapy for patients with locally advanced gastric cancer: A multicenter study [0.03%]
新辅助治疗后局部进展期胃癌的最优反应人群：一项多中心研究
Qing Zhong,Yuqin Sun,Mingqiao Lian et al.
Qing Zhong et al.
Objective: Pathologic complete response (pCR) following neoadjuvant therapy (NAT) for gastric cancer (GC) is rare but associated with a favorable prognosis. This study aims to reassess the optimal response population (ORP...
Chuhan Shen,Caijin Lin,Feilin Qu et al.
Chuhan Shen et al.
Objective: Lymphovascular invasion (LVI) is a crucial step in metastasis and is closely associated with poor prognosis in patients with breast cancer. However, its clinical and molecular characteristics remain insufficien...
Immune cell-derived exosomal non-coding RNAs in tumor microenvironment: Biological functions and potential clinical applications [0.03%]
肿瘤微环境中免疫细胞源外泌体非编码RNA的生物学功能及临床应用潜力
Chenguang Liu,Yawen Luo,Huan Zhou et al.
Chenguang Liu et al.
The intricate interactions between immune cells and tumors exert a profound influence on cancer progression and therapeutic efficacy. Within the tumor microenvironment, exosomes have emerged as pivotal mediators of intercellular communicati...
Impact of robotic surgery proportion among minimally invasive gastrectomy on surgical complications [0.03%]
微创胃切除术中机器人手术比例对术后并发症的影响
Jeong Ho Song,Yeojin Boo,Sang-Yong Son et al.
Jeong Ho Song et al.
Objective: The Safety of robotic gastrectomy (RG) compared to laparoscopic gastrectomy (LG) for gastric cancer remains uncertain on a national scale, with limited comparative studies across institutions. This study aims t...
Targeted activation of junctional adhesion molecule-like protein + CD8 + T cells enhances immunotherapy in hepatocellular carcinoma [0.03%]
靶向活化类似连接黏附分子的蛋白质和CD8阳性T细胞可增强肝癌免疫疗法疗效
Huan Chen,Zhaofeng Xiao,Zhengyang Lu et al.
Huan Chen et al.
Objective: Cytotoxic T lymphocytes (CTLs) play a crucial role in the therapeutic approach to hepatocellular carcinoma (HCC). Recent research has indicated that junctional adhesion molecule-like protein (JAML) enhances the...
Temporal trends, disease burden and attributable risk factors of stomach and colorectal cancers among 31 countries and territories in Western Pacific region, 2000 - 2021 [0.03%]
2000-2021年西太平洋地区31个国家和地区的胃癌和结直肠癌的流行趋势、疾病负担及归因危险因素
Liangyu Kang,Wenxin Yan,Wenzhan Jing et al.
Liangyu Kang et al.
Objective: This study aimed to describe the updated disease burden and temporal trends of stomach cancer (SC) and colorectal cancer (CRC), and to explore potential influence factors of the two cancers in the Western Pacif...