Ayurvedic Amalaki Rasayana promotes improved stress tolerance and thus has anti-aging effects in Drosophila melanogaster [0.03%]
阿育吠陀药Amalaki Rasayana可改善果蝇胁迫耐受性并产生抗衰老效果
Vibha Dwivedi,Subhash C Lakhotia
Vibha Dwivedi
Amalaki Rasayana (AR) is a common Ayurvedic herbal formulation of Phyllanthus emblica fruits and some other ingredients, and is used for general good health and healthy aging. We reported it to improve life history traits and to suppress ne...
Reserpine requires the D2-type receptor, dop-3, and the exoribonuclease, eri-1, to extend the lifespan in C. elegans [0.03%]
利血平通过D2型受体dop-3和核糖核酸外切酶eri-1延长秀丽隐杆线虫寿命
Kopal Saharia,Ranjeet Kumar,Kuldeep Gupta et al.
Kopal Saharia et al.
Lifespan extension is an all systems encompassing event. Involvement of reduced insulin/IGF1 signalling is well worked out, first in the model organism Caenorhbaditis elegans followed by other systems including humans. But the role of neuro...
Long non-coding RNA HOTAIR regulates proliferation and invasion via activating Notch signalling pathway in retinoblastoma [0.03%]
长非编码RNA HOTAIR通过激活Notch信号通路调节视网膜母细胞瘤的增殖和侵袭能力
Changxia Dong,Shaoyi Liu,Yongbin Lv et al.
Changxia Dong et al.
Retinoblastoma is the most frequently occurring tumour in the eyes in early childhood. Novel targets that are important for the diagnosis or treatment of retinoblastoma could be valuable in increasing the survival rate of patients affected ...
Expressions of visual pigments and synaptic proteins in neonatal chick retina exposed to light of variable photoperiods [0.03%]
变光照诱导的新生鸡视网膜视觉色素和突触蛋白表达
Kumar Abhiram Jha,Tapas C Nag,Shashi Wadhwa et al.
Kumar Abhiram Jha et al.
Light causes damage to the retina, which is one of the supposed factors for age-related macular degeneration in human. Some animal species show drastic retinal changes when exposed to intense light (e.g. albino rats). Although birds have a ...
Selective serotonin reuptake inhibitor sertraline inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells [0.03%]
选择性五羟色胺吸收抑制剂sertraline抑制兔冠状动脉平滑肌细胞电压依赖性的钾通道
Han Sol Kim,Hongliang Li,Hye Won Kim et al.
Han Sol Kim et al.
We examined the effects of the selective serotonin reuptake inhibitor (SSRI) sertraline on voltage-dependent K+ (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using the voltage-clamp technique. Sertraline dec...
Metabolic alterations derived from absence of Two-Pore Channel 1 at cardiac level [0.03%]
心脏两孔通道1缺失引起的心肌代谢改变
Vanessa Garcia-Rua,Sandra Feijoo-Bandin,Maria Garcia-Vence et al.
Vanessa Garcia-Rua et al.
Two-pore channels (TPCs or TPCNs) are novel voltage-gated ion channels that have been postulated to act as Ca2+ and/or Na+ channels expressed exclusively in acidic organelles such as endosomes and lysosomes. TPCNs participate in the regulat...
Genetic and biochemical evidences reveal novel insights into the mechanism underlying Saccharomyces cerevisiae Sae2-mediated abrogation of DNA replication stress [0.03%]
遗传和生化证据揭示了Saccharomyces cerevisiae Sae2介导的DNA复制压力消除机制的新见解
Indrajeet Ghodke,K Muniyappa
Indrajeet Ghodke
In Saccharomyces cerevisiae, the Mre11-Rad50-Xrs2 (MRX) protein complex plays pivotal roles in double-strand break (DSB) repair, replication stress and telomere length maintenance. Another protein linked to DSB repair is Sae2, which regulat...
Quaternary ammonium salt N-(dodecyloxycarboxymethyl)- N,N,N-trimethyl ammonium chloride induced alterations in Saccharomyces cerevisiae physiology [0.03%]
十二烷氧基羧甲基三甲基氯化铵 Quarternium-15 对酿酒酵母生理的影响
Ewa Oblak,Agata Piecuch,Ewa Maciaszczyk-Dziubinska et al.
Ewa Oblak et al.
We investigated the influence of the quaternary ammonium salt (QAS) called IM (N-(dodecyloxycarboxymethyl)- N,N,N-trimethyl ammonium chloride) on yeast cells of the parental strain and the IM-resistant mutant (EO25 IMR) growth. The phenotyp...
Characterization of a DUF820 family protein Alr3200 of the cyanobacterium Anabaena sp. strain PCC7120 [0.03%]
集胞藻PCC6803DUF820家族蛋白Alr3200的鉴定与表征
Prashanth S Raghavan,Gagan D Gupta,Hema Rajaram et al.
Prashanth S Raghavan et al.
The hypothetical protein 'Alr3200' of Anabaena sp. strain PCC7120 is highly conserved among cyanobacterial species. It is a member of the DUF820 (Domain of Unknown Function) protein family, and is predicted to have a DNase domain. Biochemic...
Engineering and introduction of de novo disulphide bridges in organophosphorus hydrolase enzyme for thermostability improvement [0.03%]
通过引入新的二硫键提高有机磷水解酶热稳定性
Gholamreza Farnoosh,Khosro Khajeh,Ali Mohammad Latifi et al.
Gholamreza Farnoosh et al.
The organophosphorus hydrolase (OPH) has been used to degrade organophosphorus chemicals, as one of the most frequently used decontamination methods. Under chemical and thermal denaturing conditions, the enzyme has been shown to unfold. To ...