Uptake of phenolic compounds from plant foods in human intestinal Caco-2 cells [0.03%]
植物食品中的酚类化合物在人类肠Caco-2细胞中的吸收
Gavirangappa Hithamani,Dhanya Kizhakayil,Krishnapura Srinivasan
Gavirangappa Hithamani
In continuation of our studies on the bioaccessibility of phenolic compounds from food grains as influenced by domestic processing, we examined the uptake of phenolics from native/sprouted finger millet (Eleucine coracana) and green gram (V...
Fermentative metabolism impedes p53-dependent apoptosis in a Crabtree-positive but not in Crabtree-negative yeast [0.03%]
发酵代谢抑制了一种而非种糖酵解正性的酵母中p53依赖性凋亡作用
Abhay Kumar,Jaswandi Ujwal Dandekar,Paike Jayadeva Bhat
Abhay Kumar
Tumour cells distinguish from normal cells by fermenting glucose to lactate in presence of sufficient oxygen and functional mitochondria (Warburg effect). Crabtree effect was invoked to explain the biochemical basis of Warburg effect by sug...
MicroRNA-486-5p suppresses TGF-β2-induced proliferation, invasion and epithelial-mesenchymal transition of lens epithelial cells by targeting Smad2 [0.03%]
microRNA-486-5p通过靶向Smad2抑制TGF-β2诱导的晶状体上皮细胞增殖、侵袭和上皮间质转化
Bei Liu,Jianhua Sun,Xiaoqin Lei et al.
Bei Liu et al.
The pathological development of lens epithelial cells (LECs) leads to posterior capsular opacification (PCO). This study was undertaken to investigate the effects of microRNA-486-5p (miR-486-5p) on TGF-β2-induced proliferation, invasion an...
Re-engineering the two-component systems as light-regulated in Escherichia coli [0.03%]
通过光重编程大肠杆菌的双组分系统
Siya Ma,Siwei Luo,L I Wu et al.
Siya Ma et al.
Bacteria live in environments with dynamic changes. To sense and respond to different external stimuli, bacteria make use of various sensor-response circuits, called two-component systems (TCSs). A TCS comprises a histidine protein kinase (...
Induction of morphological and functional differentiation of human neuroblastoma cells by miR-124 [0.03%]
miR-124诱导人神经母细胞瘤细胞分化及作用机制研究
Samaneh Sharif,Mohammad Hossein Ghahremani,Masoud Soleimani
Samaneh Sharif
Neuroblastoma is the most common extracranial solid tumour in children, and differentiation is considered its most appropriate therapy. In this work, we studied effects of miR-124 overexpression on differentiation in M17 cell line as a mode...
Thymoquinone induces cytotoxicity and reprogramming of EMT in gastric cancer cells by targeting PI3K/Akt/mTOR pathway [0.03%]
补骨脂素通过靶向PI3K/Akt/mTOR途径诱导胃癌细胞的毒性及上皮间质转化重编程作用
Li-Min Feng,Xue-Feng Wang,Qing-Xian Huang
Li-Min Feng
Gastric cancer is one of the lethal causes of cancer-related deaths worldwide. The incidence and mortality rates of this disease is comparatively higher in China. In the current study, we evaluated the anticancer effects of Thymoquinone (TQ...
Specific mutation of transglutaminase gene from Streptomyces hygroscopicus H197 and characterization of microbial transglutaminase [0.03%]
嗜渗性链霉菌H197转谷氨酰胺酶基因的特异突变及其微生物转谷氨酰胺酶性质分析
Wenjie Wan,Donglan He,Zhijun Xue et al.
Wenjie Wan et al.
Microbial transglutaminase (MTG) gene (mtg) from Streptomyces hygroscopicus H197 strain was cloned by PCR and mutated by deleting a specific 84 bp fragment using overlapping extension PCR. The mutant MTG and the wild MTG genes expressed by ...
Antifolate drug resistance: Novel mutations and haplotype distribution in dhps and dhfr from Northeast India [0.03%]
东北印度地区dhps和dhfr基因新型突变及其单倍型分布对抗叶酸药物抗性的影响研究
N P Sarmah,K Sarma,D R Bhattacharyya et al.
N P Sarmah et al.
Malaria is a major public health concern in Northeast India with a preponderance of drug-resistant strains. Until recently the partner drug for artemisinin combination therapy (ACT) was sulphadoxine pyrimethamine (SP). Antifolate drug resis...
What history tells us XLIV: The construction of the zinc finger nucleases [0.03%]
历史告诉我们XLIV：锌指核酸酶的构建
Michel Morange
Michel Morange