Lupeol induces S-phase arrest and mitochondria-mediated apoptosis in cervical cancer cells [0.03%]
lupeol诱导宫颈癌细胞周期阻滞和线粒体介导的细胞凋亡
Nupoor Prasad,Akash Sabarwal,Umesh C S Yadav et al.
Nupoor Prasad et al.
Cervical cancer is fourth most common fatal cancer in women worldwide. Lupeol is a dietary triterpenoid and has shown its anticancer efficacy against various cancer types with selectivity in targeting cancer cells. In the present study, ant...
Loss of mitochondrial SIRT4 shortens lifespan and leads to a decline in physical activity [0.03%]
线粒体SIRT4丢失缩短寿命并导致运动能力下降
Sweta Parik,Sandipan Tewary,Champakali Ayyub et al.
Sweta Parik et al.
Mitochondrial mechanisms and pathways have recently emerged as critical determinants of organismal aging. While nuclear sirtuins have been shown to regulate aging, whether mitochondrial sirtuins do so is still unclear. Here, we report that ...
Tapas K Kundu,Sweta Sikder
Tapas K Kundu
A cross-eyed geneticist's view I. Making sense of the lamin B receptor, a chimeric protein [0.03%]
斜视遗传学家视角我——解读杂合蛋白核膜素
Durgadas P Kasbekar
Durgadas P Kasbekar
The vertebrate inner nuclear membrane protein, lamin B receptor, has an N-terminal ~200 residue nucleoplasmic domain (NTD), and a ~420 residue C-terminal domain (CTD) that anchors the NTD to the INM. Chen et al (2016) showed the NTD interac...
Michel Morange
Michel Morange
Investigating the genetic and epigenetic basis of big biological questions with the parthenogenetic marbled crayfish: A review and perspectives [0.03%]
有性生殖副球杂交虾的孤雌生殖基因组和表观遗传组在生物学重大问题研究中的应用：综述与展望
Gunter Vogt
Gunter Vogt
In the last 15 years, considerable attempts have been undertaken to develop the obligately parthenogenetic marbled crayfish Procambarus virginalis as a new model in biology. Its main advantage is the production of large numbers of offspring...
Joyous T Joseph,Najya Jabeen Poolakkalody,Jasmine M Shah
Joyous T Joseph
Many reference genes are used by different laboratories for gene expression analyses to indicate the relative amount of input RNA/DNA in the experiment. These reference genes are supposed to show least variation among the treatments and wit...
Structure function relations in PDZ-domain-containing proteins: Implications for protein networks in cellular signalling [0.03%]
PDZ结构域蛋白的结构功能关系及其在细胞信号传导中的作用
G P Manjunath,Praveena L Ramanujam,Sanjeev Galande
G P Manjunath
Protein scaffolds as essential backbones for organization of supramolecular signalling complexes are a recurrent theme in several model systems. Scaffold proteins preferentially employ linear peptide binding motifs for recruiting their inte...
Triacylglycerol: nourishing molecule in endurance of Mycobacterium tuberculosis [0.03%]
三酰甘油：耐受性结核杆菌的滋养分子
Pratap C Mali,Laxman S Meena
Pratap C Mali
The ability of Mycobacterium tuberculosis (M. tuberculosis) to accumulate lipid-rich molecules as an energy source obtained from host cell debris remains interesting. Additionally, the potential of M. tuberculosis to survive under different...