Inhibition of miR-1247 on cell proliferation and invasion in bladder cancer through its downstream target of RAB36 [0.03%]
microRNA-1247通过其靶基因RAB36抑制膀胱癌细胞的增殖和侵袭作用
Yudi Zhu,Shaosi Liang,Huafeng Pan et al.
Yudi Zhu et al.
Recently, microRNA-1247 (miR-1247) has been reported to function as tumour suppressor in several cancer types, including pancreatic cancer, hepatocellular cancer and lung cancer. However, the biological function of miR-1247 in bladder cance...
Deletion of Dictyostelium discoideum Sir2A impairs cell proliferation and inhibits autophagy [0.03%]
Dictyostelium discoideum Sir2A基因的缺失抑制细胞增殖和自噬作用
Rakhee Lohia,Punita Jain,Mukul Jain et al.
Rakhee Lohia et al.
Sirtuins are a family of deacetylases (Class III histone deacetylases) with evolutionarily conserved functions in cellular metabolism and chromatin regulation. Out of the seven human Sirtuins, the function of Sirt2 is the least understood. ...
Putative role of invariant water molecules in the X-ray structures of family G fungal endoxylanases [0.03%]
家族G半纤维素酶的X-射线结构中假定的不变水分子的作用
Protyusha Dey,Hridoy R Bairagya,Amit Roy
Protyusha Dey
Fungal endo-1,4-beta-xylanases (EC3.2.1.8), because of their widespread industrial applications have become one of the most researched industrial enzymes in recent times. Despite its significance, the role of conserved water molecules in th...
Gender-divergent expression of lipid and bile acid metabolism related genes in adult mice offspring of dams fed a high-fat diet [0.03%]
高脂饮食母鼠后代成年小鼠与性别相关的脂质和胆汁酸代谢相关基因表达差异性研究
Yuji Tanaka,Takanori Ikeda,Kazuo Yamamoto et al.
Yuji Tanaka et al.
Maternal high-fat diet (HFD) consumption during pregnancy and lactation affects metabolic outcomes and lipid metabolism of offspring in later life in a gender-specific manner. However, it is not known whether maternal HFD alters bile acid m...
Human cathelicidin LL-37 - Does it influence the homeostatic imbalance in mental disorders? [0.03%]
人源性 Cathelicidin LL-37在精神疾病稳态失衡中的作用？
Elzbieta Kozlowska,Adam Wysokinski,Karol Majewski et al.
Elzbieta Kozlowska et al.
In addition to killing pathogens and influencing immunological processes, cathelicidin LL-37 is a multifunctional host defense peptide with a role in homeostasis. It has been suggested that imbalances in homeostatic signaling from inflammat...
Effect of PEDOT:PSS in tissue engineering composite scaffold on improvement and maintenance of endothelial cell function [0.03%]
导电高分子对组织工程复合支架上内皮细胞功能改善和维持的影响研究
Masoumeh Hesam Mahmoudinezhad,Akbar Karkhaneh,Khosrow Jadidi
Masoumeh Hesam Mahmoudinezhad
According to recent research, smart polymers can affect different kind of mammalian cells such as endothelial cells. It is known that conductive polymers have great features, e.g. electrical conductivity, and can help increase electrical ce...
In silico prediction of ErbB signal activation from receptor expression profiles through a data analytics pipeline [0.03%]
基于数据挖掘流程预测ErbB信号激活状态的计算模型
Arya A Das,Elizabeth Jacob
Arya A Das
The ErbB signalling pathway has been studied extensively owing to its role in normal physiology and its dysregulation in cancer. Reverse engineering by mathematical models use the reductionist approach to characterize the network components...
Chlorogenic acid alleviates autophagy and insulin resistance by suppressing JNK pathway in a rat model of nonalcoholic fatty liver disease [0.03%]
氯ogenic酸通过抑制JNK通路缓解非酒精性脂肪肝病大鼠模型的自噬和胰岛素抵抗
Hua Yan,Yan-Qiong Gao,Ying Zhang et al.
Hua Yan et al.
Non-alcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver diseases around the world and commonly associated with insulin resistance and hyperlipidemia. Chlorogenic acid (CG) was reported to have insulinsensitiz...
Maslinic acid modulates secreted phospholipase A2-IIA (sPLA2-IIA)-mediated inflammatory effects in macrophage foam cells formation [0.03%]
没食子酸通过调节分泌型磷脂酶A2（sPLA2）介导的炎症效应来抑制泡沫细胞形成
Wei Hsum Yap,Bee Kee Ooi,Nafees Ahmed et al.
Wei Hsum Yap et al.
Secretory phospholipase A2-IIA (sPLA2-IIA) is one of the key enzymes causing lipoprotein modification and vascular inflammation. Maslinic acid is a pentacyclic triterpene which has potential cardioprotective and anti-inflammatory properties...
Electromagnetic radiation 2450 MHz exposure causes cognition deficit with mitochondrial dysfunction and activation of intrinsic pathway of apoptosis in rats [0.03%]
2450MHz电磁辐射通过诱发线粒体功能异常和细胞凋亡而导致大鼠认知能力下降
Sukesh Kumar Gupta,Manoj Kumar Mesharam,Sairam Krishnamurthy
Sukesh Kumar Gupta
Electromagnetic radiation (EMR) can induce or modulate several neurobehavioral disorders. Duration and frequency of exposure of EMR is critical to develop cognitive disorders. Even though EMR-2450 is widely used, its effects on cognition in...