PE-only/PE_PGRS proteins of Mycobacterium tuberculosis contain a conserved tetra-peptide sequence DEVS/DXXS that is a potential caspase-3 cleavage motif [0.03%]
结核分枝杆菌PE/PPE蛋白家族含有一个保守的四肽序列DEVS/DXXS，为潜在的半胱天冬酶-3切割位点
Nandita Bachhawat
Nandita Bachhawat
Mycobacterium tuberculosis H37Rv is an intracellular pathogen responsible for causing tuberculosis in humans. The M. tuberculosis genome has been shown to contain a very large and unique family of PE proteins made of two sub-families: PE-on...
Evaluation of metabolic changes induced by polyphenols in the crayfish Astacus leptodactylus by metabolomics using Fourier transformed infrared spectroscopy [0.03%]
基于傅立叶变换红外光谱代谢组学的螃蟹甲壳素抗氧化研究
Maria Grazia Volpe,Susan Costantini,Elena Coccia et al.
Maria Grazia Volpe et al.
In the present study, the effects of polyphenols on the chemical composition of the hepatopancreas of the Astacus leptodactylus, a highly sought farmed crayfish, have been investigated by attenuated total reflectance-Fourier transform infra...
Complex interplay of lesion-specific DNA repair enzyme on bistranded clustered DNA damage harboring Tg:G mismatch in nucleosome core particles [0.03%]
核小体核心颗粒中Tg：G错配的双链聚集型DNA损伤的位点特异性DNA修复酶的作用机制
Bhavini Kumari,Kislay K Sinha,Prolay DAS
Bhavini Kumari
5,6-Dihydroxy-5,6-dihydrothymine (thymine glycol) and 7,8-dihydro-8-oxo-20-deoxyguanosine (8-oxodG) are major DNA damage lesions produced by endogenous oxidative stress, as well as inflicted by carcinogens and ionizing radiation. The proces...
Various responses of male pituitary-gonadal axis to different intensities of long-term exercise: Role of expression of KNDYrelated genes [0.03%]
不同强度长期运动对雄性下丘脑-垂体-睾丸轴影响的差异及KNDy神经元相关基因表达的作用机制
Nazli Khajehnasiri,Homayoun Khazali,Farzam Sheikhzadeh
Nazli Khajehnasiri
The essential role of regular physical activity has been emphasized for maintaining a healthy life. However, unfortunately, during the last few decades, the lifestyle of people has led to a decrease in physical activity. Research studies ha...
Fluorescence spectroscopy for revealing mechanisms in biology: Strengths and pitfalls [0.03%]
用于揭示生物学机制的荧光光谱法：优势与陷阱
G Krishnamoorthy
G Krishnamoorthy
This article describes the basic principles of steady-state and time-resolved fluorescence. The formal equivalence of the two methodologies is described first, followed by the extra advantages of time-resolved methods in revealing populatio...
Sapthaswaran Veerapathiran,Thorsten Wohland
Sapthaswaran Veerapathiran
Advanced fluorescence techniques, commonly known as the F-techniques, measure the kinetics and the interactions of biomolecules with high sensitivity and spatiotemporal resolution. Applications of the F-techniques, which were initially limi...
Single-molecule fluorescence imaging: Generating insights into molecular interactions in virology [0.03%]
单分子荧光成像：揭示病毒学中分子相互作用的新见解
Sunaina Banerjee,Satyaghosh Maurya,Rahul Roy
Sunaina Banerjee
Single-molecule fluorescence methods remain a challenging yet information-rich set of techniques that allow one to probe the dynamics, stoichiometry and conformation of biomolecules one molecule at a time. Viruses are small (nanometers) in ...
Dynamics of water and ions around DNA: What is so special about them? [0.03%]
水和离子在DNA周围的动态行为：它们有什么特别之处？
Him Shweta,Sobhan Sen
Him Shweta
Water around biomolecules is special for behaving strangely - both in terms of structure and dynamics, while ions are found to control various interactions in biomolecules such as DNA, proteins and lipids. The questions that how water and i...
Ultrafast dynamics-driven biomolecular recognition where fast activities dictate slow events [0.03%]
快速动力学驱动的生物分子识别：快速活动决定慢事件
Priya Singh,Damayanti Bagchi,Samir Kumar Pal
Priya Singh
In general, biological macromolecules require significant dynamical freedom to carry out their different functions, including signal transduction, metabolism, catalysis and gene regulation. Effectors (ligands, DNA and external milieu, etc) ...
Applications of STED fluorescence nanoscopy in unravelling nanoscale structure and dynamics of biological systems [0.03%]
STED荧光纳米显微技术在揭示生物系统纳米结构和动态方面的应用
C Roobala,I P Ilanila,J K Basu
C Roobala
Fluorescence microscopy, especially confocal microscopy, has revolutionized the field of biological imaging. Breaking the optical diffraction barrier of conventional light microscopy, through the advent of super-resolution microscopy, has u...