Machine-learning techniques for the prediction of protein-protein interactions [0.03%]
用于预测蛋白质相互作用的机器学习方法
Debasree Sarkar,Sudipto Saha
Debasree Sarkar
Protein-protein interactions (PPIs) are important for the study of protein functions and pathways involved in different biological processes, as well as for understanding the cause and progression of diseases. Several high-throughput experi...
miR-425-5p suppresses tumorigenesis and DDP resistance in human-prostate cancer by targeting GSK3β and inactivating the Wnt/β-catenin signaling pathway [0.03%]
miR-425-5p通过靶向GSK3β并抑制Wnt/β-catenin信号通路来抑制人前列腺癌的肿瘤发生和顺铂耐药性
Sheng Liu,Qin Wang,Yin Liu et al.
Sheng Liu et al.
Prostate cancer (PCa) represents the most frequently diagnosed cancer in men. Cisplatin, also known as cis-diamminedichloroplatinum (DDP), is a standard chemotherapeutic agent used to treat PCa, and DDP resistance remains one important obst...
Down-regulation effects of IFN-α on p11, 5-htr1b and 5-HTR4 protein levels were affected by NH4CL or MG132 treatment in SH-sy5y cells [0.03%]
氨氯地平或MG132处理对IFN-α下调p11、5-ht1b和5-HT4蛋白表达的影响
Jiqiang Guo,Huaxia Ding,Zhuangwei Lv et al.
Jiqiang Guo et al.
In previous studies, we found interferon-α (IFN-α) could reduce protein levels of p11, 5-hydroxytryptamine receptor 1b (5-HT1b) and 5-hydroxytryptamine receptor 4 (5-HT4), but does not influence their messenger RNA levels in SH-sy5y cells...
Does cartilage ERα overexpression correlate with osteoarthritic chondrosenescence? Indications from Labisia pumila OA mitigation [0.03%]
软骨ERα过表达与骨关节炎性软骨衰老相关吗？ 活血丹抗OA研究的启示
Iffah Nadhira Madzuki,Seng Fong Lau,Nor Aijratul Asikin Mohamad Shalan et al.
Iffah Nadhira Madzuki et al.
Chondrosenescence (chondrocyte senescence) and subchondral bone deterioration in osteoarthritic rats were analyzed after treatment with the estrogenic herb Labisia pumila (LP) or diclofenac. Osteoarthritis (OA) was induced in bilaterally ov...
Analysis of chickpea gene co-expression networks and pathways during heavy metal stress [0.03%]
重金属胁迫下 chickpea 共表达网络及通路的分析
Birendra Singh Yadav,Swati Singh,Sameer Srivastava et al.
Birendra Singh Yadav et al.
Crop productivity and yield are adversely affected by abiotic and biotic stresses. Therefore, finding out the genes responsible for stress tolerance is a significant stride towards crop improvement. A gene co-expression network is a powerfu...
Impact of Pseudomonas putida RRF3 on the root transcriptome of rice plants: Insights into defense response, secondary metabolism and root exudation [0.03%]
荧光假单胞菌RRF3对水稻根系转录组的影响：防御反应、次级代谢和根系分泌物的启示
Rekha Kandaswamy,Mohan Kumar Ramasamy,Rameshthangam Palanivel et al.
Rekha Kandaswamy et al.
Pseudomonas putida is widely used as a biocontrol agent, however, mechanisms by which it initiates the plants' defense response remains obscure. To gain an insight into the molecular changes that occur in plants upon plant growth-promoting ...
Analysis of genome-wide SNPs based on 2b-RAD sequencing of pooled samples reveals signature of selection in different populations of Haemonchus contortus [0.03%]
基于2b-RAD池测序的基因组范围SNP分析揭示了不同绵羊古柏线虫种群的适应性选择信号
Sawar Khan,Xiaochao Zhao,Yini Hou et al.
Sawar Khan et al.
The parasitic nematode Haemonchus contortus is one of the world's most important parasites of small ruminants that causes significant economic losses to the livestock sector. The population structure and selection in its various strains are...
Calycosin down-regulates c-Met to suppress development of glioblastomas [0.03%]
川culus通过下调c-Met抑制胶质母细胞瘤的发展
Xiaohu Nie,Yue Zhou,Xiaobing Li et al.
Xiaohu Nie et al.
The antitumor effect of calycosin has been widely studied, but the targets of calycosin against glioblastomas are still unclear. In this study we focused on revealing c-Met as a potential target of calycosin suppressing glioblastomas. In th...
Association of BDNF rs6265 and MC4R rs17782313 with metabolic syndrome in Pakistanis [0.03%]
BDNF rs6265 和 MC4R rs17782313 多态性与巴基斯坦人代谢综合征的关系
Sobia Rana,Ayesha Sultana,Adil Anwar Bhatti
Sobia Rana
The current case-control study sought the association of BDNF rs6265 and MC4R rs17782313 with metabolic syndrome (MetS), MetS components and other related metabolic parameters in a sample of Pakistani subjects. Fasting high-density lipoprot...
PEGylated Lipova E120 liposomes loaded with celecoxib: in-vitro characterization and enhanced in-vivo anti-inflammatory effects in rat models [0.03%]
聚乙二醇修饰的脂蛋白体E120载塞来昔布：体外特征及大鼠模型中增强的体内抗炎作用
Vivek Dave,Ashish Gupta,Priyanka Singh et al.
Vivek Dave et al.
The goal of the current investigation was to prepare PEGylated Lipova E120 liposomes loaded with celecoxib for the effective treatment of rheumatoid arthritis (RA). PEGylated liposomes were prepared and were characterized using techniques s...