Discovery of potent inhibitors from traditional rice varieties targeting α-amylase: A computational approach and in vitro validation [0.03%]
基于计算方法和体外验证的传统水稻品种中α-淀粉酶作用位点的高效抑制剂的发现
Priya Dharshini Veeraragavan,M Karunanithi,Sathya Albert
Priya Dharshini Veeraragavan
Diabetes involves complex metabolic dysregulation and necessitates approaches such as α-amylase inhibition to moderate postprandial glucose spikes and hyperglycemia. Thus, this study scrutinizes the α-amylase inhibitory potential of selec...
Kinome-wide RNAi screening in Caenorhabditis elegans reveals new modulators of insulin signaling and longevity [0.03%]
基于秀丽隐杆线虫的激酶组RNAi筛选发现胰岛素信号传导和寿命的新调节因子
Manish Chamoli,Anna Foulger,Prachi Singh et al.
Manish Chamoli et al.
The insulin/IGF-I-like signaling (IIS) pathway is a highly conserved signaling cascade that plays a crucial role in regulating longevity across species. Given its significance in aging, identifying novel kinases interacting with the IIS pat...
Meta-analysis of QTLs for drought, heat, and salinity tolerance identifies high-confidence MQTLs and candidate genes in chickpea (Cicer arietinum L.) [0.03%]
基于干旱、高温和盐胁迫的抗性QTL荟萃分析鉴定了高可信度的多环境QTL和候选基因
Shubham Sharma,Jatin Sharma,Shayla Bindra et al.
Shubham Sharma et al.
A meta-analysis of 712 quantitative trait loci (QTLs) associated with traits conferring tolerance to drought, heat, and salinity stress was conducted in chickpea. Of these, 588 QTLs were successfully projected onto a high-density consensus ...
Meta-Analysis
Journal of biosciences. 2025:50:19. DOI: 2025
O-GlcNAc transferase promotes synaptic assembly independent of catalytic activity in C. elegans [0.03%]
O-乙酰葡糖胺转移酶在C. elegans中通过非催化活性促进突触组装
Mengting Wu,Huihui Jiang,Qian Li et al.
Mengting Wu et al.
Synapses are specialized intercellular connections where neurons transfer information, and they are funda mental for complex brain functions. Synaptic assembly is precisely regulated, and its dysfunction often leads to neurodevelopmental di...
Role of public DNA-Seq data in mitogenomics research: A case study on the flying fish family (Beloniformes: Exocoetidae) [0.03%]
公共DNA-Seq数据在线粒体基因组学研究中的作用：以飞鱼科（Beloniformes: Exocoetidae）为例
Iuri Batista DA Silva,Igor Henrique Rodrigues-Oliveira,Karine Frehner Kavalco et al.
Iuri Batista DA Silva et al.
Flying fishes (Exocoetidae) are a highly specialized group of Beloniformes, with 4 subfamilies, 7 genera, and 78 species. However,only a small number of species of flying fishes have the mitochondrial genome described sof ar. Considering th...
C. elegans wired and wireless connectome: insights into principles of nervous system structure and function [0.03%]
C.elegans的有线和无线联结组：对神经系统结构与功能原理的洞见
Keertana Venkatesh,Lidia Ripoll -Sánchez,Isabel Beets et al.
Keertana Venkatesh et al.
Caenorhabditis elegans is one of the primary model organisms for neuroscience research due to its well annotated and compact nervous system. Being the first organism with a mapped connectome, published nearly 40 years ago, it holds a critic...
Review
Journal of biosciences. 2025:50:16. DOI: 2025
Innate immune and endoplasmic reticulum unfolded protein response pathways protect Caenorhabditis elegans against chloroquine toxicity [0.03%]
先天免疫和内质网未折叠蛋白反应途径保护秀丽隐杆线虫免受氯喹毒性的伤害
Rajneesh Rao,Jogender Singh
Rajneesh Rao
Chloroquine (CQ) is a 4-aminoquinoline that has historically been used as an anti-malarial drug. It has also been used to treat several autoimmune diseases, cancers, and viral infections. Most of the effects of CQ are mediated through its a...
The interplay of tuberculosis and COVID-19: Insights into global health challenges [0.03%]
结核病与COVID-19的相互作用：对全球健康挑战的洞见
Kirtimaan Syal
Kirtimaan Syal
Tuberculosis (TB), an ancient disease, has plagued humankind for centuries, and the coronavirus disease 2019 (COVID-19) pandemic has worsened the crisis. This article discusses various intersecting aspects of TB and COVID-19, including tran...
Review
Journal of biosciences. 2025:50:14. DOI: 2025
Koji Tamura
Koji Tamura
Recent analysis of samples from asteroids Ryugu and Bennu did not reveal any significant amino acid enantiomeric excesses, and these facts appear to contradict the most prevailing view that a slight enantiomeric excess of L-amino acids pres...
Review
Journal of biosciences. 2025:50:13. DOI: 2025
Caenorhabditis elegans as a model for studying intercellular communication via extracellular vesicles [0.03%]
秀丽隐杆线虫作为研究细胞外囊泡介导的细胞间通讯的模式生物
Tingting Li,Yunpeng Zhao,Yan Zou et al.
Tingting Li et al.
Intercellular communication embodies an evolutionarily conserved mechanism facilitated through the release of extracellular vesicles (EVs). These EVs, membranous structures secreted by cells, serve as carriers for a variety of biological mo...
Review
Journal of biosciences. 2025:50:12. DOI: 2025