Michel Morange
Michel Morange
ABCG2 inhibition as a therapeutic approach for overcoming multidrug resistance in cancer [0.03%]
ABCG2抑制作为克服癌症多重耐药的治疗策略
Maryam Hosseini Hasanabady,Fatemeh Kalalinia
Maryam Hosseini Hasanabady
Breast cancer resistance protein (BCRP, ABCP or MXR)/ATP-binding cassette subfamily G member 2 (ABCG2) was characterized as a multidrug resistance efflux transporter in 1998. ABCG2 physiologically acts as a part of a selfdefence mechanism f...
Bromodomain and extra-terminal (BET) family proteins: New therapeutic targets in major diseases [0.03%]
溴结构域和末端外结构域(BET)蛋白家族：重大疾病治疗的新靶标
Balasundaram Padmanabhan,Shruti Mathur,Ramu Manjula et al.
Balasundaram Padmanabhan et al.
The bromodomains and extra-terminal domain (BET) family proteins recognize acetylated chromatin through their bromodomains (BDs) and help in regulating gene expression. BDs are chromatin 'readers': by interacting with acetylated lysines on ...
The autoregulatory loop: A common mechanism of regulation of key sex determining genes in insects [0.03%]
自调节回路：昆虫关键性别决定基因调控的共同机制
Suresh Kumar Sawanth,Gajula Gopinath,Nagraj Sambrani et al.
Suresh Kumar Sawanth et al.
Sex determination in most insects is structured as a gene cascade, wherein a primary signal is passed through a series of sex-determining genes, culminating in a downstream double-switch known as doublesex that decides the sexual fate of th...
Aanisa Nazir,Rajendran Harinarayanan
Aanisa Nazir
Genes of the Rel/Spo homolog (RSH) superfamily synthesize and/or hydrolyse the modified nucleotides pppGpp/ ppGpp (collectively referred to as (p)ppGpp) and are prevalent across diverse bacteria and in plant chloroplasts. Bacteria accumulat...
Accelerated processing of solitary and clustered abasic site DNA damage lesions by APE1 in the presence of aqueous extract of Ganoderma lucidum [0.03%]
灵芝水提取物存在下APE1对单个和簇型ABS-DNA损伤修复的加速处理作用研究
Bhavini Kumari,Prolay DAS,Rekha Kumari
Bhavini Kumari
The stimulatory effect of the aqueous extract of G. lucidum, a basidiomycetes class fungus in the APE1-enzyme-mediated processing of solitary and bistranded clustered abasic sites DNA damages is presented. Abasic sites are considered the mo...
Differential expression of carotenoid biosynthetic pathway genes in two contrasting tomato genotypes for lycopene content [0.03%]
两种不同番茄基因型中类胡萝卜素生物合成途径基因的差异表达分析抗氧化物质含量遗传机制研究
Shilpa Pandurangaiah,Kundapura V Ravishankar,Kodthalu S Shivashankar et al.
Shilpa Pandurangaiah et al.
Tomato (Solanum lycopersicum L.) is one of the model plant to study carotenoid biosynthesis. In the present study, the fruit carotenoid content were quantified at different developmental stages for two contrasting genotypes, viz. IIHR-249-1...
Leptin promoter variant G2548A is associated with serum leptin and HDL-C levels in a case control observational study in association with obesity in a Pakistani cohort [0.03%]
leptin基因启动子多态位点G2548A影响巴基斯坦人群中肥胖相关的血清leptin和HDL-C水平：一项病例对照观察研究
- Shabana,Shahida Hasnain
- Shabana
Leptin is a protein hormone synthesized by adipocytes and is involved in the regulation of food intake and energy expenditure. We hypothesized that any change in the promoter sequence can affect the expression of the gene and hence leptin p...
Effects of quercetin on predator stress-related hematological and behavioral alterations in pregnant rats and their offspring [0.03%]
檞皮素对怀孕大鼠及子代应激相关的血液学和行为学改变的影响
Mohamed L Toumi,Sameha Merzoug,Abdelkrim Tahraoui
Mohamed L Toumi
This study aims at investigating the effect of a psychogenic stress during gestation on the behaviour and haematological indices in dams as well as on the neonatal haematological status and periadolescent behaviour in their offspring. Moreo...
Silencing of HMGA2 promotes apoptosis and inhibits migration and invasion of prostate cancer cells [0.03%]
HMGA2基因沉默可促进前列腺癌细胞凋亡并抑制其迁移和侵袭能力
Zhan Shi,Ding Wu,Run Tang et al.
Zhan Shi et al.
The high mobility group protein A2 (HMGA2) has been demonstrated as an architectural transcription factor that is associated with pathogenesis of many malignant cancers; however, its role in prostate cancer cells remains largely unknown. To...