Topoisomerase IB of Deinococcus radiodurans resolves guanine quadruplex DNA structures in vitro [0.03%]
德尼博克辐射耐菌拓扑异构酶IB能体外解析鸟嘌呤四链体DNA结构
Swathi Kota,Hari S Misra
Swathi Kota
Published Erratum
Journal of biosciences. 2016 Mar;41(1):167. DOI:10.1007/s12038-016-9594-0 2016
Sukla Ghosh
Sukla Ghosh
The main objective of regenerative medicine is to replenish cells or tissues or even to restore different body parts that are lost or damaged due to disease, injury and aging. Several avenues have been explored over many decades to address ...
A Nagabhushana,Rakesh K Mishra
A Nagabhushana
How sex is determined has been one of the most intriguing puzzles in biology since antiquity. Although a fundamental process in most metazoans, there seems to be myriad of ways in which sex can be determined - from genetic to environmental ...
In silico dissection of Type VII Secretion System components across bacteria: New directions towards functional characterization [0.03%]
细菌中类型的分泌系统组件的计算机分解：功能表征的新方向
Chandrani Das,Tarini Shankar Ghosh,Sharmila S Mande
Chandrani Das
Type VII Secretion System (T7SS) is one of the factors involved in virulence of Mycobacterium tuberculosis H37Rv. Numerous research efforts have been made in the last decade towards characterizing the components of this secretion system. An...
Transcriptome analysis of stem wood of Nothapodytes nimmoniana (Graham) Mabb. identifies genes associated with biosynthesis of camptothecin, an anti-carcinogenic molecule [0.03%]
诺氏无患子茎干转录组分析鉴定与卡博替尼抗癌分子生物合成相关基因
B L Manjunatha,H R Singh,G Ravikanth et al.
B L Manjunatha et al.
Camptothecin (CPT), a monoterpene indole alkaloid, is a potent inhibitor of DNA topoisomerase I and has applications in treating ovarian, small lung and refractory ovarian cancers. Stem wood tissue of Nothapodytes nimmoniana (Graham) Mabb. ...
Identification and validation of a virus-inducible ta-siRNA-generating TAS4 locus in tomato [0.03%]
番茄病毒诱导的TAS4位点产生ta-siRNA的鉴定和验证
Archana Singh,Shradha Saraf,Indranil Dasgupta et al.
Archana Singh et al.
Trans-acting small interfering RNAs (ta-siRNAs) are a class of endogenous small RNA, associated with posttranscriptional gene silencing. Their biogenesis requires an initial microRNA (miRNA)-mediated cleavage of precursor RNA. Around 20 dif...
Do prion protein gene polymorphisms induce apoptosis in non-mammals? [0.03%]
朊病毒蛋白基因多态性诱导非哺乳动物细胞凋亡吗？
Tuğçe Birkan,Mesut Şahin,Zubeyde Öztel et al.
Tuğçe Birkan et al.
Genetic variations such as single nucleotide polymorphisms (SNPs) in prion protein coding gene, Prnp, greatly affect susceptibility to prion diseases in mammals. Here, the coding region of Prnp was screened for polymorphisms in redeared tur...
Cystathionine-γ-lyase gene silencing with siRNA in monocytes/ macrophages attenuates inflammation in cecal ligation and puncture-induced sepsis in the mouse [0.03%]
单核细胞/巨噬细胞中胱硫醚-γ-裂解酶基因沉默通过siRNA减轻盲肠结扎穿孔诱导的脓毒症中小鼠炎症反应
A Badiei,S T Chambers,R R Gaddam et al.
A Badiei et al.
Hydrogen sulphide is an endogenous inflammatory mediator produced by cystathionine-γ-lyase (CSE) in macrophages. To determine the role of H2S and macrophages in sepsis, we used small interference RNA (siRNA) to target the CSE gene and inve...
MiR-128b is down-regulated in gastric cancer and negatively regulates tumour cell viability by targeting PDK1/Akt/NF-κB axis [0.03%]
胃癌中microRNA-128b表达下调并通过靶向PDK1/Akt/NF-κB信号轴抑制肿瘤细胞活力
Ling Zhang,Jun Lei,Zi-Ling Fang et al.
Ling Zhang et al.
Gastric cancer (GC) is the fourth most prevalent type of cancer worldwide, which is usually caused by the interaction between environmental and genetic factors, or epigenetic aspects. Referring to the non-coding RNAs, miR-128b has been repo...
Zinc finger protein 521 overexpression increased transcript levels of Fndc5 in mouse embryonic stem cells [0.03%]
锌指蛋白521过表达可上调小鼠胚胎干细胞中Fndc5的转录水平
Motahere-Sadat Hashemi,Abbas Kiani Esfahani,Maryam Peymani et al.
Motahere-Sadat Hashemi et al.
Zinc finger protein 521 is highly expressed in brain, neural stem cells and early progenitors of the human hematopoietic cells. Zfp521 triggers the cascade of neurogenesis in mouse embryonic stem cells through inducing expression of the ear...