Therapeutic potential of the heme oxygenase-1 inducer hemin against Ebola virus infection [0.03%]
血红素诱导剂对埃博拉病毒感染的治疗潜力HO-1诱导剂hemin对抗埃博拉病毒感染的治疗潜力
Hanxia Huang,Krishnamurthy Konduru,Veronica Solovena et al.
Hanxia Huang et al.
Promising drugs to treat Ebola virus (EBOV) infection are currently being developed, but so far none has shown efficacy in clinical trials. Drugs that can stimulate host innate defense responses may retard the progression of EBOV disease. W...
Ramadan A Ali,Leah M Wuescher,Randall G Worth
Ramadan A Ali
Platelets are anucleate cell fragments known for their central role in coagulation and vascular integrity. However, it is becoming increasingly clear that platelets contribute to diverse immunological processes extending beyond the traditio...
Heme oxygenase-1-mediated host cell response inhibits the susceptibility of prostate cancer cells to retroviral infection and retards their proliferation [0.03%]
血红素氧合酶1介导的宿主细胞反应抑制前列腺癌细胞的病毒感染易感性并减缓其增殖
Zhao-Hua Zhou,Namita Kumari,Jennifer Catalano et al.
Zhao-Hua Zhou et al.
Xenotropic murine leukemia virus-related virus (XMRV) resembles endogenous murine leukemia virus and was used in this study as a model for a new retrovirus infecting human cells. We demonstrate that induction of an HO-1-mediated host cell r...
Lessons learned from studies of natural resistance in murine experimental autoimmune encephalomyelitis [0.03%]
小鼠实验性自身免疫性脑脊髓炎自然抵抗机制研究的启示
Harley Y Tse,Jinzhu Li,Xiaoqing Zhao et al.
Harley Y Tse et al.
Experimental autoimmune encephalomyelitis (EAE) is a commonly-used animal model of the human demyelinating disease, multiple sclerosis (MS). Similar to MS, EAE is under genetic control in that certain mouse strains are susceptible to diseas...
Current trends in negative immuno-synergy between two sexually transmitted infectious viruses: HIV-1 and HSV-1/2 [0.03%]
当前两种性传播感染病毒HIV-1和HSV-1/2之间负面免疫协同作用的现状及趋势分析
Aziz Alami Chentoufi,Xavier Dervillez,Pierre-Alain Rubbo et al.
Aziz Alami Chentoufi et al.
In the current era of effective anti-retroviral therapy, immuno-compromised patients with HIV-1 infection do live long enough to suffer diseases caused by many opportunistic infections, such as herpes simplex virus type 1 and/or type 2 (HSV...
Why rethink the structure-function relationships regulating TCR behavior? [0.03%]
为什么需要重新思考调节TCR行为的结构功能关系？
Melvin Cohn
Melvin Cohn
Although the generally accepted (Standard) Model of the TCR has powered the accumulation of a large body of crucial data, it is lacking because of the failure of its basic tenet that allele-specific recognition of MHC-encoded restricting el...
Janina Jiang,Kathleen A Kelly
Janina Jiang
T cells with the specialized ability to suppress both adaptive and innate immune responses have been identified and called T regulatory cells (Tregs). The primary function of Tregs is to maintain a balance between immunity (foreign Ag) and ...
THE MULTIFACETED ROLE OF T CELL-MEDIATED IMMUNITY IN PATHOGENESIS AND RESISTANCE TO MYCOPLASMA RESPIRATORY DISEASE [0.03%]
细胞介导的免疫在肺炎支原体发病机制和抵抗力中的多重作用
Nicole A Dobbs,Adam N Odeh,Xiangle Sun et al.
Nicole A Dobbs et al.
Mycoplasma respiratory diseases have a significant impact on the economy, health and wildlife. The hallmark of these diseases is the persistence of the mycoplasma infections and chronic inflammatory responses associated with the airways. Th...