Cyclopia in a newborn rhesus macaque born to a dam infected with SIV and receiving antiretroviral therapy during pregnancy [0.03%]
感染了SIV并接受抗逆转录病毒治疗的母恒河猴所生新生儿单眼畸形综合征出生案例报告
Lara Doyle-Meyers,Chunming Dong,Eddie Qidi Xu et al.
Lara Doyle-Meyers et al.
Cyclopia, a rare genetic anomaly and birth defect, was recently observed in our nonhuman primate study. A newborn rhesus macaque, delivered via cesarean section, exhibited facial abnormalities, including a single eye in the middle of the fo...
Targeting the stage-specific embryonic antigen (SSEA)-0 tumor neoantigen [0.03%]
靶向阶段特异性胚胎抗原(SSEA)-0肿瘤新抗原
Denong Wang
Denong Wang
Recognition of abnormal glycosylation in virtually any cancer type has raised a great interest in the glycan-based tumor biomarkers. Our team explored carbohydrate microarrays as a broad-spectrum immunoassay to probe the immunologically pot...
Yung-An Huang,Allyssa Strohm,Taylor Doherty
Yung-An Huang
Type 2 airway diseases including chronic rhinosinusitis, allergic rhinitis, and asthma remain a major health concern. These disorders are largely characterized by an uncontrolled type 2 immune response with elevated cytokines of IL-4, IL-5 ...
The "Janus-like" RNA-editing machinery in innate antiviral immunity [0.03%]
先天抗病毒免疫中的“两面神 JANUS 似的”RNA编辑系统
Lisa Wu,Denong Wang
Lisa Wu
Our innate immune systems are evolved to provide the first line of immune defense against microbial infections. A key effector component is the adenosine deaminase acting on the RNA-1 (ADAR-1)/interferon (IFN) pathway of the innate cytoplas...
Denong Wang
Denong Wang
A successful global healthcare response relies on versatile vaccines and production of broadly virus-neutralizing antibodies by the immune system to protect us from emerging infectious diseases. The present 2019 severe acute respiratory syn...
Shilpa Kodati,Sunil K Chauhan,Yihe Chen et al.
Shilpa Kodati et al.
The purpose of this study is to determine the effect of systemic blockade of Interleukin-6 (IL-6) on allosensitization, regulatory T cell frequencies and suppressive phenotype, and allograft survival rates in a mouse model of corneal transp...
Liang Guo,Irina Vlasova-St Louis,Paul R Bohjanen
Liang Guo
Cytokines and cytokine signaling pathways are crucial for regulating cellular functions, including cell growth, proliferation, differentiation, and cell death. Cytokines regulate physiological processes such as immune responses and maintain...
Defective iron homeostasis in human immunodeficiency virus type-1 latency [0.03%]
人类免疫缺陷病毒1型潜伏期铁稳态异常
Hanxia Huang,Zhao-Hua Zhou,Rewati Adhikari et al.
Hanxia Huang et al.
Highly active antiretroviral therapy has significantly improved the life of HIV-1-infected individuals, yet complete eradication of HIV-1 reservoirs (i.e., latently infected cells) remains a major challenge. We have previously shown that in...
Emerging immunotherapeutics in adenocarcinomas: A focus on CAR-T cells [0.03%]
腺癌的新兴免疫治疗药物：CAR-T细胞疗法备受关注
Mahboubeh Yazdanifar,Ru Zhou,Pinku Mukherjee
Mahboubeh Yazdanifar
More than 80% of all cancers arise from epithelial cells referred to as carcinomas. Adenocarcinomas are the most common type of carcinomas arising from the specialized epithelial cells that line the ducts of our major organs. Despite many a...
Nikolaos Patsoukis,Kankana Bardhan,Jessica Weaver et al.
Nikolaos Patsoukis et al.
T lymphocytes undergo extensive changes in their metabolic properties during their transition through various differentiation states, from naïve to effector to memory or regulatory roles. The cause and effect relationship between metabolis...