The Apolipoprotein E Mimetic Peptide AEM-2 Attenuates Mitochondrial Injury And Apoptosis In Human THP-1 Macrophages [0.03%]
人THP-1巨噬细胞中载脂蛋白E模拟肽AEM-2减轻线粒体损伤和凋亡
Samantha Giordano-Mooga,Geeta Datta,Paul Wolkowicz et al.
Samantha Giordano-Mooga et al.
Cardiovascular disease, specifically atherosclerosis, is exacerbated by hypercholesterolemia. Current therapies that target lipid lowering, however, are not effective in all patients. Apolipoprotein E (apoE) plays an important role in media...
a-Factor: a chemical biology tool for the study of protein prenylation [0.03%]
用于蛋白质异戊二烯化研究的化学生物学工具a-因子
Veronica Diaz-Rodriguez,Mark D Distefano
Veronica Diaz-Rodriguez
The mating pheromone a-factor is a lipidated dodecapeptide found in the budding yeast S. cerevisiae. The biosynthesis of this peptide encompasses the same three-step processing pathway (farnesylation of C-terminal cysteine, C-terminal prote...
Yen-Chih Wang,Mark D Distefano
Yen-Chih Wang
Peptide libraries are useful tools to investigate the relationship between structure and function of proteins. The creation of peptide libraries with free C-termini presents unique synthetic challenges. In this review, methods for creating ...
Cryptic activity within the Type III1 domain of fibronectin regulates tissue inflammation and angiogenesis [0.03%]
纤维连接蛋白III1结构域内的隐蔽活性调节组织炎症和血管生成
Christina Cho,Rhiannon Kelsh-Lasher,Anthony Ambesi et al.
Christina Cho et al.
The fibronectin matrix provides mechanical and biochemical information to regulate homeostatic and pathological processes within tissues. Fibronectin consists of independently-folded modules termed Types I, II and III. In response to cellul...
Modulating the dysregulated migration of pulmonary arterial hypertensive smooth muscle cells with motif mimicking cell permeable peptides [0.03%]
利用模体模拟的细胞可渗透肽调节肺动脉高压平滑肌细胞的异常迁移
Jamie L Wilson,Chamila Rupasinghe,Anny Usheva et al.
Jamie L Wilson et al.
Migration of vascular smooth muscle cells is a key element in remodeling during pulmonary arterial hypertension (PAH). We are observing key alterations in the migratory characteristics of human pulmonary artery smooth muscle cells (HPASMC) ...
Guangshun Wang
Guangshun Wang
Human immunodeficiency virus type 1 (HIV-1) infection remains to be one of the major global health problems. It is thus necessary to identify novel therapeutic molecules to combat HIV-1. Natural antimicrobial peptides (AMPs) have been recog...