Bruno P Klaholz
Bruno P Klaholz
The central dogma of molecular biology comprises two fundamental mechanistic steps of gene expression (transcription and translation), which, in bacteria, are coupled. A recent study provides structural insights into a supercomplex between ...
Kliment A Verba,David A Agard
Kliment A Verba
The Hsp90/Cdc37 chaperone system interacts with and supports 60% of the human kinome. Not only are Hsp90 and Cdc37 generally required for initial folding, but many kinases rely on the Hsp90/Cdc37 throughout their lifetimes. A large fraction...
Richard Calendar
Richard Calendar
d-Aminoacyl-tRNA deacylase (DTD) hydrolyzes d-amino acids mistakenly attached to tRNAs and, thus, has been implicated in perpetuating protein homochirality. Fifty years after the discovery of DTD, it has now been shown that its function ext...
A Process of Resection-Dependent Nonhomologous End Joining Involving the Goddess Artemis [0.03%]
一种依赖切除的非同源末端连接过程涉及到女神阿尔忒弥斯
Markus Löbrich,Penny Jeggo
Markus Löbrich
DNA double-strand breaks (DSBs) are a hazardous form of damage that can potentially cause cell death or genomic rearrangements. In mammalian G1- and G2-phase cells, DSBs are repaired with two-component kinetics. In both phases, a fast proce...
Phosphatidylserine Is the Signal for TAM Receptors and Their Ligands [0.03%]
磷脂酰丝氨酸是TYRO3/AIRM/TIFF受体及其配体的信号分子
Greg Lemke
Greg Lemke
Nature repeatedly repurposes, in that molecules that serve as metabolites, energy depots, or polymer subunits are at the same time used to deliver signals within and between cells. The preeminent example of this repurposing is ATP, which fu...
Linda C Johansson,Benjamin Stauch,Andrii Ishchenko et al.
Linda C Johansson et al.
X-ray free electron lasers (XFELs) have the potential to revolutionize macromolecular structural biology due to the unique combination of spatial coherence, extreme peak brilliance, and short duration of X-ray pulses. A recently emerged ser...
Shobbir Hussain
Shobbir Hussain
Transcriptome plasticity, usually associated with alternative isoform generation, is recognised as a key mechanism driving proteomic diversity and biological complexity. Recent findings of Liscovitch-Brauer et al. and Ma et al. suggest that...
Hiroshi Yamamoto,Anett Unbehaun,Christian M T Spahn
Hiroshi Yamamoto
Internal initiation is a 5'-end-independent mode of translation initiation engaged by many virus- and putatively some cell-encoded templates. Internal initiation is facilitated by specific RNA tertiary folds, called internal ribosomal entry...
Darren J Baker,Shahaf Peleg
Darren J Baker
Organismal aging is classically viewed as a gradual decline of cellular functions and a systemic deterioration of tissues that leads to an increased mortality rate in older individuals. According to the prevailing theory, aging is accompani...