Roberto Munita
Roberto Munita
The 'complete story' has become the standard in top journals. Narrative structure helps communicate science, but requiring mechanistic completeness for publication can exclude important discoveries, delay their dissemination, and push resea...
Wei Yu,Yu Fang,Shixian Lin et al.
Wei Yu et al.
The site-specific incorporation of noncanonical amino acids (ncAAs) has revolutionized protein research. However, synthesizing multifunctional biopolymers demands moving beyond single-type ncAA incorporation to simultaneously encoding multi...
The multifunctional, stress-sensitive ribonuclease angiogenin cross-regulates different gene expression processes [0.03%]
多功能且受压力影响的核糖核酸酶血管生成素交叉调节不同的基因表达过程
Ana C de A P Schwarzer,Markus T Bohnsack,Katherine E Bohnsack
Ana C de A P Schwarzer
Ribonucleases shape gene expression by mediating RNA processing and degradation. Angiogenin (ANG) is a prominent ribonuclease implicated in several pathophysiologies that contributes to multiple cellular processes by targeting different RNA...
Transglutaminase 2 drives histone monoaminylation as an epigenetic mechanism in health and disease [0.03%]
转谷氨酰胺酶2驱动组蛋白单氨基化作为健康与疾病中的表观遗传机制
Anne A Leaman,Zeng Lin,Qingfei Zheng
Anne A Leaman
Transglutaminases (TGs) were originally discovered to catalyze protein-protein crosslinking by forming isopeptide bonds between the side chains of lysine and glutamine. Recently, TGs have been found to mediate the bioconjugation between pro...
Pyruvylation: a link bridging metabolic disorders and impaired antiviral immunity [0.03%]
丙酮酸酯化：代谢异常和抗病毒免疫受损之间的纽带
Song Yang,Lili Gong,Lihong Liu
Song Yang
Zuo et al. identified a novel post-translational modification-protein pyruvylation-and revealed that pyruvate, a glycolysis metabolite, induces STAT1 pyruvylation at Lys201, which blocks signal transducer and activator of transcription 1 (S...
Dan Kehila,Paola Laurino
Dan Kehila
Recent work by Sakuma et al. shows that the ubiquitous enzyme alkaline phosphatase (PhoA) can oxidize phosphite, revealing a new metabolic role for a classic catalytic generalist. Despite its relatively low efficiency, PhoA's global distrib...
Molecular mechanisms of PINK1/Parkin-mediated mitochondrial quality control [0.03%]
PINK1/ Parkin介导的线粒体质量控制的分子机制研究进展
Andrew N Bayne,Jean-François Trempe
Andrew N Bayne
PINK1/Parkin-mediated mitophagy and other related mitochondrial quality control pathways are critical to maintaining cellular homeostasis and neuronal health, and indeed, mutations in PINK1 and PRKN that disrupt this pathway cause early-ons...
Reaction hijacking of enzymes to generate potent therapeutic modulators in situ [0.03%]
利用酶反应劫持原位生成有效的治疗调节因子
Stanley C Xie,Yun Shi,Bostjan Kobe et al.
Stanley C Xie et al.
Enzymes play critical roles in all aspects of biology, making them important targets for therapeutics in infectious diseases and cancer. In addition to the well-known and exploited competitive and suicide inhibitors, reaction hijacking comp...
Aria A Khalique,Aaron M Leconte
Aria A Khalique
Engineered DNA polymerases capable of synthesizing RNA have the potential to make the synthesis of site-specifically labeled RNA faster, cheaper, and more user-friendly. After many years of trying, two recent reports, by Chen et al. and Med...