Skylar D King,Krista M Angileri,Cynthia Lebel et al.
Skylar D King et al.
The framework and practical tools presented in this article enable neurodivergent scientists, mentors, research teams, and institutions to better understand the cognitive and environmental factors that shape scientific work. By normalizing ...
Krista M Angileri,Cynthia Lebel,Gabrielle Farulla-Bastian et al.
Krista M Angileri et al.
Scientific innovation thrives on diverse problem-solving for modern interdisciplinary challenges. Neurodivergent scientists provide unique perspectives essential for high-impact discovery. We use the 'Neurodiversity Iceberg' to show how cog...
Tamor A Khan
Tamor A Khan
Building scientific communities for the future of the molecular life sciences: The role of FEBS [0.03%]
面向未来构建分子生命科学学术共同体：欧州生物化学基金会的作用
Miguel A De la Rosa
Miguel A De la Rosa
Since 1964, the Federation of European Biochemical Societies has supported the molecular life sciences through scientific exchange, training, international collaboration, and publishing. This study provides an overview of the organisation's...
Membrane lipid sensing during ERAD: coupling lipid composition to proteostatic fate [0.03%]
内质网相关降解过程中膜脂感应：将脂类组成与蛋白质稳态命运相结合
Aikaterini Vrentzou,Alexander Stein
Aikaterini Vrentzou
The endoplasmic reticulum (ER) membrane is both the central site of cellular lipid synthesis and the platform on which ER-associated degradation (ERAD) selects membrane proteins for ubiquitination and proteasomal destruction. ERAD shapes ER...
Linkerology in PROTACs: learnings for proximity-inducing therapeutics [0.03%]
PROTACs中的连接组学：空间诱导型药物的启示
Rubén Prieto-Díaz,Aina Urbina,María Rodríguez-Ríos et al.
Rubén Prieto-Díaz et al.
Targeted protein degradation has rapidly evolved from a chemical biology concept into a therapeutic modality, with the first proteolysis-targeting chimera (PROTAC) degrader now approved as a medicine. Linkers play a central role in governin...
Chris Greening,James D Archer
Chris Greening
The atmosphere is increasingly recognised as a major energy source supporting life. Numerous microbes, termed aerotrophs, use high-affinity enzymes to harvest energy from atmospheric hydrogen, carbon monoxide, and methane. This metabolism s...
Alberto Vázquez-Salazar
Alberto Vázquez-Salazar
Forty years after the term 'RNA world' was coined, the RNA world hypothesis is best framed as an RNA-centered evolutionary phase rather than as an RNA-only biosphere. Recent advances in systems chemistry now turn several long-standing objec...
Structure and dynamics of the Nipah virus RNA-dependent RNA polymerase [0.03%]
尼帕病毒RNA依赖型RNA聚合酶的结构与功能动态
Fernanda A Sala,Hauke S Hillen
Fernanda A Sala
Nipah virus (NiV) is a highly pathogenic, nonsegmented, negative-sense RNA virus (nsNSV) from the Mononegavirales order that causes frequent outbreaks, with no approved treatment available. Replication and transcription of its genome are ca...
Natalia Wawrzyniak,Eduardo Eyras,Justin J-L Wong
Natalia Wawrzyniak
N6-methyladenosine (m6A) is the most prevalent internal modification in eukaryotic mRNA, influencing RNA fate and gene regulation. Early antibody-based approaches enabled transcriptome-wide profiling but lacked resolution and quantitative a...