Regulation of inflammatory gene transcription by ubiquitination and deubiquitination [0.03%]
泛素化和去泛素化介导的炎症基因转录调控研究进展
Zixu Liu
Zixu Liu
Transcriptional responses are initiated immediately after the recognition of pathogen-associated molecular patterns by pattern recognition receptors, enabling host cells to deal with inflammatory stimuli, including microbial infections. In ...
Magical moments in protease biology: proteasome autocatalytic activation and PI31-mediated inhibition [0.03%]
蛋白酶生物学中的神奇时刻：蛋白酶体的自催化激活和PI31介导抑制
Tamayanthi Rajakumar,Erignacio Fermin Perez,Darlene Fung et al.
Tamayanthi Rajakumar et al.
Proteases regulate nearly every aspect of cellular function. Spatial and temporal control of protease activity contributes to this functional versatility and includes both zymogen activation mechanisms and the existence of dedicated proteas...
Sri Ramya Donepudi
Sri Ramya Donepudi
Supporting young life scientists worldwide through the IUBMB Trainee Initiative [0.03%]
通过IUBMB学员计划在全球范围内支持年轻生命科学家
Sana Ahmed,Patrick Penndorf
Sana Ahmed
The International Union of Biochemistry and Molecular Biology Trainee Initiative supports early-career researchers globally. This overview covers what researchers gain from the initiative, such as funding pathways, science communication tra...
Integrating techniques and disciplines to drive structural and chemical biology forward [0.03%]
融合学科和技术推进结构和化学生物学的发展
Arun K Shukla,Yael David
Arun K Shukla
Sannie Culbertson
Sannie Culbertson
Bei Nan,Shan Gao
Bei Nan
DNA methylation events, including 5-methylcytosine (5mC) and N6-methyladenine (6mA), represent key epigenetic marks with distinct roles across eukaryotic genomes. Although traditionally viewed as fundamentally divergent, emerging evidence, ...
Diversity in CDK structural mechanisms of regulation and drug discovery opportunities [0.03%]
CDK调控结构机制的多样性及药物研发机遇
Rhianna J Rowland,Martin E M Noble,Jane A Endicott
Rhianna J Rowland
Cyclin-dependent kinases (CDKs) are required for progression through the eukaryotic cell cycle and for gene transcription. The recent determination of structures of CDK-containing complexes by cryogenic electron microscopy has significantly...
BacPROTAC-induced protein degradation as a new antibiotic concept [0.03%]
由BacPROTAC诱导的蛋白质降解作为新的抗生素概念
Sabryna Junker,Tim Clausen
Sabryna Junker
Antibiotic resistance is spreading worldwide, associated with more than 5 million deaths annually, yet few new antibiotics have emerged in recent years. This gap highlights the need for alternative strategies that enable the rational design...
Expanding enzyme functionality through site-specific incorporation of noncanonical amino acids [0.03%]
通过非天然氨基酸的定点掺入扩展酶的功能性
Siddiq Pasha Shaik,Anni Li,Jiantao Guo et al.
Siddiq Pasha Shaik et al.
Enzymes are nature's catalysts, capable of performing complex chemical transformations with remarkable precision and efficiency, yet their potential is confined by the chemistry of 20 canonical amino acids. The advent of genetic code expans...