Chris Greening,James D Archer
Chris Greening
The atmosphere is increasingly recognised as a major energy source supporting life. Numerous microbes, termed aerotrophs, use high-affinity enzymes to harvest energy from atmospheric hydrogen, carbon monoxide, and methane. This metabolism s...
Alberto Vázquez-Salazar
Alberto Vázquez-Salazar
Forty years after the term 'RNA world' was coined, the RNA world hypothesis is best framed as an RNA-centered evolutionary phase rather than as an RNA-only biosphere. Recent advances in systems chemistry now turn several long-standing objec...
Structure and dynamics of the Nipah virus RNA-dependent RNA polymerase [0.03%]
尼帕病毒RNA依赖型RNA聚合酶的结构与功能动态
Fernanda A Sala,Hauke S Hillen
Fernanda A Sala
Nipah virus (NiV) is a highly pathogenic, nonsegmented, negative-sense RNA virus (nsNSV) from the Mononegavirales order that causes frequent outbreaks, with no approved treatment available. Replication and transcription of its genome are ca...
Natalia Wawrzyniak,Eduardo Eyras,Justin J-L Wong
Natalia Wawrzyniak
N6-methyladenosine (m6A) is the most prevalent internal modification in eukaryotic mRNA, influencing RNA fate and gene regulation. Early antibody-based approaches enabled transcriptome-wide profiling but lacked resolution and quantitative a...
Shi-Ying Yao,Meng Wang,Fan-Yan Wei et al.
Shi-Ying Yao et al.
Mitochondrial tRNAs (mt-tRNAs) are central to energy production by translating essential oxidative phosphorylation subunits. Following transcription, mt-tRNAs undergo diverse processing steps, post-transcriptional modifications, and aminoac...
Sarah Lewandowski,Lea Sophie Pommerening,Sutapa Chakrabarti
Sarah Lewandowski
Regulation of gene expression in cells is mediated by RNA-binding proteins (RBPs), which act as adaptors connecting messenger RNA (mRNA) to enzymatic and structural components to achieve a distinct functional outcome. RBPs are enriched in i...
A unified mechanism of phosphate export across eukaryotes through EXS domain-containing proteins [0.03%]
一种通过含EXS结构域蛋白在真核生物中统一的磷酸盐外排机制
Ghazanfar Abbas Khan,Elycia Calvet,Jean-Luc Battini et al.
Ghazanfar Abbas Khan et al.
Inorganic phosphate (Pi) is an essential macronutrient, and tight regulation of Pi import and export is required to maintain Pi homeostasis. Although Pi import mechanisms have been extensively characterized, the molecular basis of Pi export...
Yushu Li,Jiaqi Wang,Tiantian Wang et al.
Yushu Li et al.
Genomic and proteomic initiatives have accelerated therapeutic target identification, yet many proteins remain difficult to drug, especially those lacking structural information, including those with intrinsically disordered regions. Howeve...
Giulia Pesce,Salvador Ventura
Giulia Pesce
Translated sequences are often treated as either genes or noise. A recent TransCODE Consortium study by Deutsch et al. introduces peptideins: endogenous proteins with evidence of synthesis but an unresolved biological status. This concept o...
Hao Zhang,Benke Hong
Hao Zhang
A recent study by Chang et al. uncovers a series of cryptic glycosylated intermediates and previously elusive enzymes that complete the nicotine biosynthesis. They demonstrate that nicotine biosynthetic enzymes and a transporter assemble in...