Kavita J Rangan,Howard C Hang
Kavita J Rangan
The intestine is a highly complex ecosystem where many bacterial species interact with each other and host cells to influence animal physiology and susceptibility to pathogens. Genomic methods have provided a broad framework for understandi...
Jonathan A Stefely,David J Pagliarini
Jonathan A Stefely
Coenzyme Q (CoQ, ubiquinone) is a redox-active lipid produced across all domains of life that functions in electron transport and oxidative phosphorylation and whose deficiency causes human diseases. Yet, CoQ biosynthesis has not been fully...
Stefano Gianni,Per Jemth
Stefano Gianni
There is increasing interest in studying protein interactions and their role in cell biology using kinetics. However, there is confusion about the proper terminology in terms of the distinction between rates and rate constants. We recommend...
Ming Chen,Guangming Zeng,Piao Xu et al.
Ming Chen et al.
Enzymes are fundamental biological catalysts responsible for biological regulation and metabolism. The opportunity for enzymes to 'meet' nanoparticles and nanomaterials is rapidly increasing due to growing demands for applications in nanoma...
Emerging Structural Understanding of Amyloid Fibrils by Solid-State NMR [0.03%]
固体核磁共振在揭示淀粉样纤维结构方面的最新认识
Beat H Meier,Roland Riek,Anja Böckmann
Beat H Meier
Amyloid structures at atomic resolution have remained elusive mainly because of their extensive polymorphism and because their polymeric properties have hampered structural studies by classical approaches. Progress in sample preparation, as...
Wilhelm Voth,Ursula Jakob
Wilhelm Voth
Proteins are constantly challenged by environmental stress conditions that threaten their structure and function. Especially problematic are oxidative, acid, and severe heat stress which induce very rapid and widespread protein unfolding an...
Emerging Insights into the Roles of the Paf1 Complex in Gene Regulation [0.03%]
PAF1复合体在基因调控中的作用的新见解
S Branden Van Oss,Christine E Cucinotta,Karen M Arndt
S Branden Van Oss
The conserved, multifunctional Polymerase-Associated Factor 1 complex (Paf1C) regulates all stages of the RNA polymerase (Pol) II transcription cycle. In this review, we examine a diverse set of recent studies from various organisms that bu...
Franziska Püschel,Cristina Muñoz-Pinedo
Franziska Püschel
Entosis is an atypical form of cell death that occurs when a cell engulfs and kills another cell. A recent article by Overholtzer and colleagues indicates that glucose deprivation promotes entosis. AMP-activated protein kinase (AMPK) activa...
There Is an Inclusion for That: Material Properties of Protein Granules Provide a Platform for Building Diverse Cellular Functions [0.03%]
一粒多用——蛋白质颗粒的多样细胞功能及其物质属性
Daniel Kaganovich
Daniel Kaganovich
Proteins perform a staggering variety of functions in the cell. Traditionally, protein function was thought to be hard-wired into the folded structure and conformational dynamics of each protein molecule. Recent work describes a new mode of...
Victor Bustos,Linda Partridge
Victor Bustos
Aging is the single greatest risk factor for the development of disease. Understanding the biological molecules and mechanisms that modulate aging is therefore critical for the development of health-maximizing interventions for older people...