Chris de Graaf,Gaojie Song,Can Cao et al.
Chris de Graaf et al.
The secretin-like class B family of G protein-coupled receptors (GPCRs) are key players in hormonal homeostasis. Recent structures of various receptors in complex with a variety of orthosteric and allosteric ligands provide fundamental new ...
Nan Hao,Keith E Shearwin
Nan Hao
Bacterial sigma54 (σ54) promoters are the DNA-binding motif for σ54-containing RNA polymerase (RNAP) holoenzymes. A recent study using a combination of synthetic oligonucleotide library screening, biochemical characterization, and bioinfo...
Histone Marks in the 'Driver's Seat': Functional Roles in Steering the Transcription Cycle [0.03%]
组蛋白修饰的“驾辕”作用：调控转录周期的功能作用
Leah A Gates,Charles E Foulds,Bert W O&#x;Malley
Leah A Gates
Particular chromatin modifications are associated with different states of gene transcription, yet our understanding of which modifications are causal 'drivers' in promoting transcription is incomplete. Here, we discuss new developments des...
Cracking the Chaperone Code: Cellular Roles for Hsp70 Phosphorylation [0.03%]
破解伴侣蛋白代码：Hsp70磷酸化的细胞作用
Nitika,Andrew W Truman
Nitika
Heat shock protein 70 (Hsp70) is a molecular chaperone required for protein folding, cell viability, and cancer cell proliferation. Recent studies suggest that Hsp70 phosphorylation regulates important cellular processes, such as cell cycle...
Kevin S Cannon,Benjamin L Woods,Amy S Gladfelter
Kevin S Cannon
Membrane curvature is a fundamental feature of cells and their organelles. Much of what we know about how cells sense curved surfaces comes from studies examining nanometer-sized molecules on nanometer-scale curvatures. We are only just beg...
Outer Membrane Protein OmpB Methylation May Mediate Bacterial Virulence [0.03%]
外膜蛋白OmpB甲基化可能介导细菌致病性
David C H Yang,Amila H Abeykoon,Bok-Eum Choi et al.
David C H Yang et al.
Methylation of outer membrane proteins (OMPs) has been implicated in bacterial virulence. Lysine methylation in rickettsial OmpB is correlated with rickettsial virulence, and N- and O-methylations are also observed in virulence-relevant OMP...
Hodaya Hochberg,Yaron Shav-Tal
Hodaya Hochberg
RNA editing results in the site-specific conversion of adenosine to inosine in mRNAs. Genomics has revealed millions of editing sites in metazoans, but examining the spatial aspects of editing in cells has been challenging. A new method, in...
Kimberly C Lin,Hyun Woo Park,Kun-Liang Guan
Kimberly C Lin
The TEAD transcription factor family is best known for transcriptional output of the Hippo signaling pathway and has been implicated in processes such as development, cell growth and proliferation, tissue homeostasis, and regeneration. Our ...
Sharing the SAGA [0.03%]
共享SAGA体验
Dominique Helmlinger,László Tora
Dominique Helmlinger
Transcription initiation is a major regulatory step in eukaryotic gene expression. Co-activators establish transcriptionally competent promoter architectures and chromatin signatures to allow the formation of the pre-initiation complex (PIC...
Yong Tae Kwon,Aaron Ciechanover
Yong Tae Kwon
The conjugation of the 76 amino acid protein ubiquitin to other proteins can alter the metabolic stability or non-proteolytic functions of the substrate. Once attached to a substrate (monoubiquitination), ubiquitin can itself be ubiquitinat...