Yuchao Zhang,Haitao Zhang,Bin Zhao
Yuchao Zhang
Hippo signaling has a pivotal role in organ size control, tissue regeneration, and cancer. Recent studies have demonstrated critical functions of Hippo signaling in cancer immunity, innate immune responses against pathogens, and autoimmune ...
Immune Responses - Transcriptional and Post-Transcriptional Networks Pass the Baton [0.03%]
免疫应答-转录和转录后网络传递接力棒
Johannes Lichti,Christian Gallus,Elke Glasmacher
Johannes Lichti
Diverse gene regulatory mechanisms impact on immune homeostasis, and a new model now emerges as fundamental in light of recent genome-wide studies. In this picture, transcriptional networks drive functional changes during immune activation,...
Nico Dissmeyer,Emmanuelle Graciet,Michael J Holdsworth et al.
Nico Dissmeyer et al.
N-term 2017 was the first international meeting to bring together researchers from diverse disciplines with a shared interest in protein N-terminal modifications and the N-end rule pathway of ubiquitin-mediated proteolysis, providing a plat...
The PAQosome, an R2TP-Based Chaperone for Quaternary Structure Formation [0.03%]
R2TP依赖型分子伴侣PAQosome促进蛋白质四级结构组装
Walid A Houry,Edouard Bertrand,Benoit Coulombe
Walid A Houry
The Rvb1-Rvb2-Tah1-Pih1/prefoldin-like (R2TP/PFDL) complex is a unique chaperone that provides a platform for the assembly and maturation of many key multiprotein complexes in mammalian cells. Here, we propose to rename R2TP/PFDL as PAQosom...
Kelsey N Maxwell,Yong Zhou,John F Hancock
Kelsey N Maxwell
The ability of lipid-anchored small GTPases to form nanometer-scale lipid domains on the cell plasma membrane (PM) is precipitating exciting new insights into membrane-anchored protein regulation. A recent article by Remorino et al. demonst...
Elodie Lafont,Torsten Hartwig,Henning Walczak
Elodie Lafont
Despite its name, signalling induced by the tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is versatile. Besides eliciting cell death by both apoptosis and necroptosis, TRAIL can also induce migration, proliferation,...
Jerry Eichler,Barbara Imperiali
Jerry Eichler
In the three domains of life, lipid-linked glycans contribute to various cellular processes ranging from protein glycosylation to glycosylphosphatidylinositol anchor biosynthesis to peptidoglycan assembly. In generating many of these glycoc...
Sharanya Sivanand,Isabella Viney,Kathryn E Wellen
Sharanya Sivanand
The epigenome is sensitive to the availability of metabolites that serve as substrates of chromatin-modifying enzymes. Links between acetyl-CoA metabolism, histone acetylation, and gene regulation have been documented, although how specific...
Opposing Functions of Heparanase-1 and Heparanase-2 in Cancer Progression [0.03%]
癌蛋白透明质酸酶-1和生成性蛋白透明质酸酶-2在癌症进展中的相反功能
Israel Vlodavsky,Miriam Gross-Cohen,Marina Weissmann et al.
Israel Vlodavsky et al.
Heparanase, the sole heparan sulfate (HS)-degrading endoglycosidase, regulates multiple biological activities that enhance tumor growth, metastasis, angiogenesis, and inflammation. Heparanase accomplishes this by degrading HS and thereby re...
Lars Ellgaard,Carolyn S Sevier,Neil J Bulleid
Lars Ellgaard
The reversal of thiol oxidation in proteins within the endoplasmic reticulum (ER) is crucial for protein folding, degradation, chaperone function, and the ER stress response. Our understanding of this process is generally poor but progress ...