Michael Schneider,Adam Belsom,Juri Rappsilber
Michael Schneider
Observing the structures of proteins within the cell and tracking structural changes under different cellular conditions are the ultimate challenges for structural biology. This, however, requires an experimental technique that can generate...
Inês Gomes Castro,Maya Schuldiner,Einat Zalckvar
Inês Gomes Castro
The eukaryotic cell is organized as a complex grid system where membrane-bound cellular compartments, organelles, must be localized to the right place at the right time. One way to facilitate correct organelle localization and organelle coo...
Yuanyuan Chen,Ross E Dalbey
Yuanyuan Chen
Oxa1/Alb3/YidC family members promote the insertion of proteins into the mitochondrial inner membrane, the chloroplast thylakoid membrane, and the bacterial plasma membrane. Remarkably, two recent studies identify new Oxa1 homologs that res...
Replication-Coupled Nucleosome Assembly in the Passage of Epigenetic Information and Cell Identity [0.03%]
表观遗传信息和细胞身份传递中的核小体装配及其子链复制耦联机制研究
Albert Serra-Cardona,Zhiguo Zhang
Albert Serra-Cardona
During S phase, replicated DNA must be assembled into nucleosomes using both newly synthesized and parental histones in a process that is tightly coupled to DNA replication. This DNA replication-coupled process is regulated by multitude of ...
Resolving the Gordian Knot: Srs2 Strips Intermediates Formed during Homologous Recombination [0.03%]
解开 gordian 结扣：Srs2 在同源重组过程中去除 intermediates
Harshad Ghodke,Jacob S Lewis,Antoine M van Oijen
Harshad Ghodke
Cells use a suite of specialized enzymes to repair chromosomal double-strand breaks (DSBs). Two recent studies describe how single-molecule fluorescence imaging techniques are used in the direct visualization of some of the key molecular st...
Archa H Fox,Shinichi Nakagawa,Tetsuro Hirose et al.
Archa H Fox et al.
Long noncoding RNA (lncRNA) molecules are some of the newest and least understood players in gene regulation. Hence, we need good model systems with well-defined RNA and protein components. One such system is paraspeckles - protein-rich nuc...
Manoj B Menon,Matthias Gaestel
Manoj B Menon
MK2 (p38MAPK-activated protein kinase 2) is essential for tumor necrosis factor (TNF) biosynthesis, mainly operating by post-transcriptional regulation. Deletion of the gene encoding MK2 strongly reduced serum TNF and protected against endo...
Adam H Courtney,Wan-Lin Lo,Arthur Weiss
Adam H Courtney
The mechanisms by which a T cell detects antigen using its T cell antigen receptor (TCR) are crucial to our understanding of immunity and the harnessing of T cells therapeutically. A hallmark of the T cell response is the ability of T cells...
Jeffrey B Woodruff,Anthony A Hyman,Elvan Boke
Jeffrey B Woodruff
Cells compartmentalize biochemical reactions using organelles. Organelles can be either membrane-bound compartments or supramolecular assemblies of protein and ribonucleic acid known as 'biomolecular condensates'. Biomolecular condensates, ...
Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mammalian Cell Differentiation [0.03%]
基于Cul3的泛素连接酶在哺乳动物细胞分化中的作用机制研究
Wolfgang Dubiel,Dawadschargal Dubiel,Dieter A Wolf et al.
Wolfgang Dubiel et al.
Specificity of the ubiquitin proteasome system is controlled by ubiquitin E3 ligases, including their major representatives, the multisubunit cullin-RING ubiquitin (Ub) ligases (CRLs). More than 200 different CRLs are divided into seven fam...