Nadinath B Nillegoda,Anne S Wentink,Bernd Bukau
Nadinath B Nillegoda
Protein aggregates are formed in cells with profoundly perturbed proteostasis, where the generation of misfolded proteins exceeds the cellular refolding and degradative capacity. They are a hallmark of protein conformational disorders and a...
SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond [0.03%]
固醇调节元件结合蛋白(SREBP)与脂代谢、胰岛素信号转导及其他生物学过程
Russell A DeBose-Boyd,Jin Ye
Russell A DeBose-Boyd
Sterol regulatory element-binding proteins (SREBPs) are a family of membrane-bound transcription factors that activate genes encoding enzymes required for synthesis of cholesterol and unsaturated fatty acids. SREBPs are controlled by multip...
Katherine E Sloan,Markus T Bohnsack
Katherine E Sloan
RNA helicases are critical regulators at the nexus of multiple pathways of RNA metabolism, and in the complex cellular environment, tight spatial and temporal regulation of their activity is essential. Dedicated protein cofactors play key r...
Guiding Mitotic Progression by Crosstalk between Post-translational Modifications [0.03%]
蛋白质修饰互作引导有丝分裂进程
Sabine A G Cuijpers,Alfred C O Vertegaal
Sabine A G Cuijpers
Cell division is tightly regulated to disentangle copied chromosomes in an orderly manner and prevent loss of genome integrity. During mitosis, transcriptional activity is limited and post-translational modifications (PTMs) are responsible ...
Correction to: 'The Warburg Effect: How Does it Benefit Cancer Cells?': [Trends in Biochemical Sciences, 41 (2016) 211] [0.03%]
《魏格尔效应:它如何有利于癌细胞?:[生物化学科学趋势,41(2016 ) 211]的更正通知
Maria V Liberti,Jason W Locasale
Maria V Liberti
Published Erratum
Trends in biochemical sciences. 2016 Mar;41(3):287. DOI:10.1016/j.tibs.2016.01.004 2016
Reactive Acyl-CoA Species Modify Proteins and Induce Carbon Stress [0.03%]
酰基-CoA反应性活性物种可修饰蛋白质并引起碳应激
Alec G Trub,Matthew D Hirschey
Alec G Trub
In recent years, our understanding of the scope and diversity of protein post-translational modifications (PTMs) has rapidly expanded. In particular, mitochondrial proteins are decorated with an array of acyl groups that can occur non-enzym...
Zhimin Lu,Tony Hunter
Zhimin Lu
Protein kinases regulate every aspect of cellular activity, whereas metabolic enzymes are responsible for energy production and catabolic and anabolic processes. Emerging evidence demonstrates that some metabolic enzymes, such as pyruvate k...
Christoffel P S Badenhorst,Uwe T Bornscheuer
Christoffel P S Badenhorst
Applied biocatalysis is driven by environmental and economic incentives for using enzymes in the synthesis of various pharmaceutical and industrially important chemicals. Protein engineering is used to tailor the properties of enzymes to ca...
Methylation of Elongation Factor 1A: Where, Who, and Why? [0.03%]
elongation factor 1a的甲基化：何处？何人？为何？
Joshua J Hamey,Marc R Wilkins
Joshua J Hamey
Eukaryotic elongation factor 1A (eEF1A) is an essential and highly conserved protein involved in diverse cellular processes, including translation, cytoskeleton organisation, nuclear export, and proteasomal degradation. Recently, nine novel...
Alexey L Arkov
Alexey L Arkov
Gene regulation by PIWI-piRNA complexes is determined by the selection of cognate target RNAs by PIWI-piRNA. What are the mechanisms for this selection? There is a rigorous multistep control in identifying target RNAs by PIWI-piRNA structur...