Qiuyan Chen,Tina M Iverson,Vsevolod V Gurevich
Qiuyan Chen
Arrestins are a small family of proteins with four isoforms in humans. Remarkably, two arrestins regulate signaling from >800 G protein-coupled receptors (GPCRs) or nonreceptor activators by simultaneously binding an activator and one out o...
Stephen B Liggett
Stephen B Liggett
G-protein-coupled receptors (GPCRs) are the targets for many drugs, but the response shows interindividual variability. The 'one-drug-fits-all' approach has been challenged by evidence showing multiple human genetic variants of GPCRs. Ident...
Catherine L Shelton,Audrey L Lamb
Catherine L Shelton
The menaquinone, siderophore, and tryptophan (MST) enzymes transform chorismate to generate precursor molecules for the biosynthetic pathways defined in their name. Kinetic data, both steady-state and transient-state, and X-ray crystal stru...
Salvatore Nesci
Salvatore Nesci
The molecular structure of the transmembrane domain of ATP synthases is responsible for the inner mitochondrial membrane bending. According to the hypothesized mechanism, ATP synthase dissociation from dimers to monomers, triggered by Ca2+ ...
Stuart Kyle
Stuart Kyle
Affimer proteins can bind to a wide variety of target molecules. They can complement and represent a promising alternative to conventional antibodies as they can target molecules with high affinity, specificity, and stability. In addition, ...
Neal F Lue
Neal F Lue
Recent studies have resulted in deeper understanding of a variety of telomere maintenance mechanisms as well as plausible models of telomere evolution. Often overlooked in the discussion of telomere regulation and evolution is the synthesis...
Chad J Miller,Benjamin E Turk
Chad J Miller
Protein phosphorylation is the most common reversible post-translational modification in eukaryotes. Humans have over 500 protein kinases, of which more than a dozen are established targets for anticancer drugs. All kinases share a structur...
The Cytokinin-Activating LOG-Family Proteins Are Not Lysine Decarboxylases [0.03%]
局部合成细胞分裂素激活酶LOG蛋白不是 lysine decarboxylases 类酶
Muhammad Naseem,Elena Bencurova,Thomas Dandekar
Muhammad Naseem
A conserved PGGxGTxxE motif misleads the cytokinin (CK) converting LONELY GUY enzymes to be wrongly annotated as lysine decarboxylases (LDCs). However, so far PGGxGTxxE motif-containing LDCs do not show any LDC activity. Instead, they show ...
Fine-Tuning Limited Proteolysis: A Major Role for Regulated Site-Specific O-Glycosylation [0.03%]
精炼的蛋白质水解作用：调控的位点特异性O-糖基化的作用
Christoffer K Goth,Sergey Y Vakhrushev,Hiren J Joshi et al.
Christoffer K Goth et al.
Limited proteolytic processing is an essential and ubiquitous post-translational modification (PTM) affecting secreted proteins; failure to regulate the process is often associated with disease. Glycosylation is also a ubiquitous protein PT...
Shobbir Hussain
Shobbir Hussain
De novo sequence-level surveys of transcriptomes have previously relied on sequencing via a DNA intermediate. While such methods can yield massive data sets, various problems mean that these do not always accurately reflect the true innate ...