Amazing Diversity in Biochemical Roles of Fe(II)/2-Oxoglutarate Oxygenases [0.03%]
Fe(II)/α-酮戊二酸氧酶的生化功能多样性令人惊叹
Caitlyn Q Herr,Robert P Hausinger
Caitlyn Q Herr
Since their discovery in the 1960s, the family of Fe(II)/2-oxoglutarate-dependent oxygenases has undergone a tremendous expansion to include enzymes catalyzing a vast diversity of biologically important reactions. Recent examples highlight ...
Lea H Gregersen,Jesper Q Svejstrup
Lea H Gregersen
In response to transcription-blocking DNA lesions such as those generated by UV irradiation, cells activate a multipronged DNA damage response. This response encompasses repair of the lesions that stall RNA polymerase (RNAP) but also a poor...
Kyle P Eagen
Kyle P Eagen
Chromosomes are folded and compacted in interphase nuclei, but the molecular basis of this folding is poorly understood. Chromosome conformation capture methods, such as Hi-C, combine chemical crosslinking of chromatin with fragmentation, D...
Alejandra Medina-Rivera,David Santiago-Algarra,Denis Puthier et al.
Alejandra Medina-Rivera et al.
Gene expression in higher eukaryotes is precisely regulated in time and space through the interplay between promoters and gene-distal regulatory regions, known as enhancers. The original definition of enhancers implies the ability to activa...
Guillermo Rodrigo,Nigel G Stocks
Guillermo Rodrigo
Noise in gene expression is pervasive and, in some cases, even fulfills a functional role. Cancer cell populations exploit noise to increase heterogeneity as a defense against therapies. What lies behind this picture is a phenomenon of stoc...
A Nilsson,J R Haanstra,B Teusink et al.
A Nilsson et al.
Quantifying the rate of consumption and release of metabolites (i.e., flux profiling) has become integral to the study of cancer. The fluxes as well as the growth of the cells may be affected by metabolite depletion during cultivation. ...
Kirstin Gutekunst
Kirstin Gutekunst
All life on earth requires a source of energy and organic carbon. There has been a continuous debate on whether autotrophic or heterotrophic metabolism came first. A very similar discussion exists concerning the advent of oxygenic photosynt...
Juozas Baltusnikas,Saulius Satkauskas,Kenneth Lundstrom
Juozas Baltusnikas
Long-term transcriptional gene silencing has been hampered by delivery issues. A potential solution is the application of RNA viruses that generate small RNAs without any DNA intermediate. Long-term therapy for various diseases is expected ...
Probing Ion Channel Structure and Function Using Light-Sensitive Amino Acids [0.03%]
利用光敏氨基酸探测离子通道的结构和功能
Viktoria Klippenstein,Laetitia Mony,Pierre Paoletti
Viktoria Klippenstein
Approaches to remotely control and monitor ion channel operation with light are expanding rapidly in the biophysics and neuroscience fields. A recent development directly introduces light sensitivity into proteins by utilizing photosensitiv...
Xinran Feng,Shouqing Luo,Boxun Lu
Xinran Feng
Expanded polyglutamine (polyQ) stretches within endogenous proteins cause at least nine human diseases. The structural basis of polyQ pathogenesis is the key to understanding fundamental mechanisms of these diseases, but it remains unclear ...