Ting Fu,Yifan Lyu,Hui Liu et al.
Ting Fu et al.
Deriving from logical and mechanical interactions between DNA strands and complexes, DNA-based artificial reaction networks (RNs) are attractive for their high programmability, as well as cascading and fan-out ability, which are similar to ...
Ivan N Shatsky,Ilya M Terenin,Victoria V Smirnova et al.
Ivan N Shatsky et al.
Eukaryotic translation initiation relies on the m7G cap present at the 5' end of all mRNAs. Some viral mRNAs employ alternative mechanisms of initiation based on internal ribosome entry. The 'IRES ideology' was adopted by researchers to exp...
Mohamed A Eldeeb,Richard P Fahlman
Mohamed A Eldeeb
Neurodegeneration-associated hallmarks include an abundance of protein aggregates and amelioration of mitochondrial function. Despite the knowledge of molecular counteracting mechanisms, the molecular dialogue between protein aggregate accu...
Feixiong Cheng,Ruth Nussinov
Feixiong Cheng
The underlying genetic causes and altered signaling pathways of brain arteriovenous malformations remain unknown. A study published in The New England Journal of Medicine reported that KRAS somatic mutations (p.Gly12Val/Asp) were identified...
Nicholas R Pannunzio,Michael R Lieber
Nicholas R Pannunzio
A subset of chromosomal translocations related to B cell malignancy in human patients arises due to DNA breaks occurring within defined 20-600 base pair (bp) zones. Several factors influence the breakage rate at these sites including transc...
Emerging Paradigm of Intracellular Targeting of G Protein-Coupled Receptors [0.03%]
细胞内靶向G蛋白偶联受体的新范式
Madhu Chaturvedi,Justin Schilling,Alexandre Beautrait et al.
Madhu Chaturvedi et al.
G protein-coupled receptors (GPCRs) recognize a diverse array of extracellular stimuli, and they mediate a broad repertoire of signaling events involved in human physiology. Although the major effort on targeting GPCRs has typically been fo...
Jianhua Xiong
Jianhua Xiong
Mitochondrial fatty acid β-oxidation (FAO) is a major catabolic process that degrades long-chain fatty acids. Recent reports reveal a broad role for FAO in cell fate control in endothelial cells, immune cells, and cancer cells. Concurrentl...
Kendra R Vann,Tatiana G Kutateladze
Kendra R Vann
Polycomb repressive complex 2 (PRC2) is a chief epigenetic regulator. In a new article, Chen et al. describe the crystal structure of the heterotetrameric PRC2 holo complex, which provides important mechanistic insights into the organizatio...
Ebrahim Aboualizadeh,Carol J Hirschmugl
Ebrahim Aboualizadeh
An emerging application of mid-IR spectrochemical imaging of the retina is its utility in studying the highly localized biomolecular alterations in the chemistry of retinal cell layers associated with several pathological conditions. Spatia...
Why Do Disordered and Structured Proteins Behave Differently in Phase Separation? [0.03%]
无序蛋白和结构化蛋白为何在相分离中的行为不同？
Huan-Xiang Zhou,Valery Nguemaha,Konstantinos Mazarakos et al.
Huan-Xiang Zhou et al.
Intracellular membraneless organelles and their myriad cellular functions have garnered tremendous recent interest. It is becoming well accepted that they form via liquid-liquid phase separation (LLPS) of protein mixtures (often including R...