Engineered protein inhibitors for precise targeting of matrix metalloproteinases [0.03%]
工程化蛋白质抑制剂精准靶向基质金属蛋白酶
Naama Rotenberg,Noam Y Bentolila,Julia M Shifman
Naama Rotenberg
Matrix metalloproteinases (MMPs) are a family of 23 zinc-dependent proteases involved in extracellular matrix (ECM) remodeling and are implicated in diseases such as cancer, arthritis, and cardiovascular disorders. Broad-spectrum MMP inhibi...
Justin Legleiter
Justin Legleiter
Huntington's disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin (HTT) gene, resulting in an expanded polyglutamine (polyQ) tract in HTT protein. Expanded polyQ tracts cause mutant HTT (mHTT) to a...
Sol C Begue,Emanuela Leonardi,Silvio C E Tosatto
Sol C Begue
The rise of AlphaFold and similar structure predictors has made it possible to determine the 3D structure of almost any protein from its amino acid sequence. Residue interaction networks (RINs), graphs where residues are represented as node...
Intrinsic disorder and fuzzy interactions drive multiple functions of HMGB1 [0.03%]
HMGB1通过内在无序和模糊的相互作用行使多种功能
Michela Ghitti,Liam Sean Colley,Malisa Vittoria Mantonico et al.
Michela Ghitti et al.
HMGB1, a multitasking protein, is scrutinized here through the lens of the 'fuzzy interactions' driven by its intrinsically disordered regions (IDRs). Although the multiple intracellular and extracellular functions of this protein have been...
Molecular design drives nanoarchitecture in self-assembling antimicrobial peptides [0.03%]
分子设计驱动了抗菌肽自组装的纳米结构
Thuanny Borba Rios,Mariana Rocha Maximiano,Nelson Gomes de Oliveira Junior et al.
Thuanny Borba Rios et al.
Antimicrobial peptides (AMPs) have emerged as promising alternatives owing to their broad-spectrum activity and reduced potential for resistance. Recent advances have highlighted the role of peptide self-assembly in enhancing the stability,...
How interactions between oxidized DNA and the NLRP3 inflammasome fuel inflammatory disease [0.03%]
氧化DNA与NLRP3炎性小体相互作用如何驱动炎症性疾病
Angela Lackner,Lemuel Leonidas,Alijah Macapagal et al.
Angela Lackner et al.
Recent discoveries have emphasized the critical role of oxidized DNA (ox-DNA) in inflammation and immune regulation. Produced during oxidative stress from infection or tissue damage, ox-DNA activates signaling pathways that drive the releas...
PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease [0.03%]
翻译：泛素化修饰为分子编码：重塑分子伴侣成为上分子伴侣以用于疾病的网络控制
Feixia Chu,Sahil Sharma,Stephen D Ginsberg et al.
Feixia Chu et al.
Recent discoveries reveal that post-translational modifications (PTMs) do more than regulate protein activity - they encode conformational states that transform chaperones into epichaperomes: multimeric scaffolds that rewire protein-protein...
Michaela Oborská-Oplová,Michael A Ruoss,Vikram G Panse
Michaela Oborská-Oplová
Cells depend on the efficient import of thousands of nuclear-encoded mitochondrial proteins to maintain mitochondrial function. A new study by Flohr et al. reveals a quality control strategy that traps a subset of mitochondrial precursors i...
The multilayered regulation of aromatic amino acid biosynthesis in plants [0.03%]
植物芳香族氨基酸生物合成的多层次调控机制研究进展
Jorge El-Azaz,Hiroshi A Maeda
Jorge El-Azaz
The shikimate and aromatic amino acid (AAA) biosynthetic pathways are crucial for the production of L-phenylalanine (Phe), L-tyrosine (Tyr), and L-tryptophan (Trp), as well as vitamins, hormones, and an array of plant natural products, incl...
Exploring nondegrading molecular glues for protein-protein interactions [0.03%]
探索用于蛋白质-蛋白质相互作用的非降解分子胶黏剂
Sitong Yu,Lixin Zhou,Jing Yang et al.
Sitong Yu et al.
Protein-protein interactions (PPIs) are central to cellular signaling and represent attractive, yet challenging drug targets. While molecular glue degraders (MGDs) promote target degradation via E3 ligase recruitment, nondegrading molecular...