Epigenetic regulation of circadian clocks by chromatin dynamics from fungi to mammals [0.03%]
从真菌到哺乳动物的昼夜节律钟的染色体动态表观遗传调控
Xiao-Lan Liu,Muqun Yu,Zeyu Duan et al.
Xiao-Lan Liu et al.
Circadian clocks allow eukaryotes to adapt to the daily cycles caused by the Earth's rotation. At the molecular level, circadian oscillators consist of transcriptional-translational negative feedback loops that drive circadian rhythms. Epig...
Adenosylhomocysteinase-adenosine complex links m6A and cancer lipid metabolism [0.03%]
S-腺苷同型半胱氨酸酶-腺苷复合物连接m6A和癌症脂质代谢
Hang Qin,Yajie Qi,Yanqiang Li
Hang Qin
Methionine metabolism is canonically linked to gene regulation through S-adenosylmethionine (SAM)-dependent methylation of RNA. Recently, Liao et al. revealed a SAM-independent mechanism wherein adenosylhomocysteinase-adenosine complex modu...
Dade Rong,Shuai You,Han-Ming Shen
Dade Rong
Adenosine Monophosphate (AMP)-activated protein kinase (AMPK) is a critical kinase in the control of cellular metabolism, and in recent years, accumulating evidence has demonstrated that AMPK plays a critical role in the regulation of vario...
Carlos Vela-Rodríguez,Albert Galera-Prat,Jonathan N Pruneda et al.
Carlos Vela-Rodríguez et al.
Post-translational modifications (PTMs) can regulate the localization, function, and activity of proteins. Different PTMs can influence each other to create complex regulatory networks with significant implications for cellular signaling an...
Memory on demand: how RNA-free Cas9 recharges CRISPR immunity [0.03%]
按需记忆：RNA-free Cas9如何重置CRISPR免疫系统
Frances Y Tsai,Samuel H Sternberg
Frances Y Tsai
Bacteria and archaea acquire immune memories by integrating foreign DNA into clustered regularly interspaced short palindromic repeats (CRISPR) arrays. Zhou et al. reveal that Cas9-thought to act only with guide RNAs-also functions in its R...
Mitoxyperilysis: fasting-induced cell death in immunometabolism and disease [0.03%]
线粒体过氧化裂解：免疫代谢及疾病中的饥饿诱导细胞死亡
Radhwan Al-Zidan,Manjul Gautam,Si Ming Man
Radhwan Al-Zidan
Recent work by Wang and colleagues reveals a unique mode of cell death called mitoxyperilysis, driven by mitochondrial proximity-dependent rupture of the plasma cell membrane. This lytic cell death is triggered by immune agonists combined w...
Artificial intelligence revolutionizes cellular metabolic pathway reconstruction [0.03%]
人工智能革新细胞代谢途径重构
Jiangbin Zheng,Xinyan Xu,Qirong Yang et al.
Jiangbin Zheng et al.
Cellular metabolic pathway reconstruction is an essential yet challenging goal in synthetic biology. We outline a conceptual framework integrating retrosynthetic planning with biological constraints to enhance biological feasibility. We bel...
Decoding disease-relevant variants with base and prime editors at scale [0.03%]
大规模使用碱基编辑器和先导编辑器解码疾病相关变异体
Ying Liu,Xuran Niu,Wensheng Wei
Ying Liu
Interpreting variants of uncertain significance remains a central challenge in human genomics. Base and prime editors have launched a new era of precision functional genomics, enabling programmable, double-strand break-free introduction of ...
Mechanism and regulation of meiotic double-strand break formation in mammals [0.03%]
哺乳动物减数重组双链断裂的机制和调控
Xinzhe Tang,Ming-Han Tong
Xinzhe Tang
Programmed DNA double-strand breaks (DSBs) catalyzed by the conserved topoisomerase-like complex SPO11-TOP6BL, together with its accessory proteins, initiate meiotic recombination, a process central to meiosis. In mammals, DSBs are distribu...
A conundrum resolved: regulation and activation of UvrD-family DNA helicases/translocases [0.03%]
一个难题的解决：UvrD家族DNA解旋酶/转位酶的调控与激活
Timothy M Lohman,Kacey N Mersch,Ankita Chadda et al.
Timothy M Lohman et al.
Superfamily 1 helicases are conserved nonhexameric ATP-dependent enzymes that unwind DNA and RNA duplexes processively or remove proteins, playing critical roles in DNA repair, replication, recombination, and RNA processing. While crystal s...