Laura Quintero-Pantoja,Gonzalo Millán-Zambrano
Laura Quintero-Pantoja
Metabolic enzymes are emerging as key regulators of nuclear processes. A recent study by Srivastava et al. shows that the nucleotide biosynthetic enzyme phosphoribosyl pyrophosphate synthetase 1 participates in early histone maturation, hig...
Kaitlyn Toy,Jenna N Beyer,George M Burslem
Kaitlyn Toy
Understanding the highly dynamic nature of many cellular processes requires techniques that provide access to proteins with precise spatial or temporal control. While genetically encodable tags provide experimental access to a protein of in...
Bacterial transformation [0.03%]
细菌转化作用
Dominika Dobosz
Dominika Dobosz
Shina Caroline Lynn Kamerlin,Salvador Ventura
Shina Caroline Lynn Kamerlin
TiBS at 50 [0.03%]
TiBS五十华诞
Sannie Culbertson
Sannie Culbertson
Single-stranded DNA-binding proteins at healthy and diseased telomeres [0.03%]
单链DNA结合蛋白在健康的端粒和疾病端粒中的作用
Gaëlle Lescalet,Alberto David Delgado Monterroso,Rima Kochman et al.
Gaëlle Lescalet et al.
The repetitive G-/C-rich nature of telomeres makes them potent obstacles to replicative DNA polymerases, eliciting a state of replication stress during genome duplication. Within replisomes and as part of the shelterin complex, numerous sin...
Ana Lago-Maciel,Marcello Herzog,Johannes G Rebelein
Ana Lago-Maciel
Nitrogenases are the only enzymes capable of converting atmospheric nitrogen into bioavailable ammonia, an essential process for all life on Earth. Early ancestors of bona fide nitrogenases and their maturases gave rise to several structura...
New insights in regulation of RAS isoforms revealed by protein structures [0.03%]
蛋白质结构揭示的调控RAS亚型的新见解
Taiki Abe,Alice H Berger
Taiki Abe
Leucine zipper-like post translational regulator 1 (LZTR1) functions as a RAS degrader, but the molecular basis of LZTR1-RAS regulation has remained unclear. A recent report by Dharmaiah et al. presents crystal structures of the LZTR1 Kelch...
Emerging structural insights into PRC2 function in development and disease [0.03%]
Polycomb repressive complex 2的功能和结构对其在发育及疾病中作用的启示
Mohd Y Bhat,Xin Liu
Mohd Y Bhat
Polycomb repressive complex 2 (PRC2) is a key epigenetic enzyme complex that mediates developmental gene repression mainly by depositing the repressive H3K27me3 histone mark. PRC2 operates through its distinct forms, PRC2.1 and PRC2.2, each...
Structural transport and inhibition mechanism of the mitochondrial pyruvate carrier [0.03%]
线粒体丙酮酸载体的结构转运及抑制机制
Denis Lacabanne,Jonathan J Ruprecht,Maximilian Sichrovsky et al.
Denis Lacabanne et al.
The mitochondrial pyruvate carrier (MPC), of the SLC54 family of solute carriers, has a critical role in eukaryotic energy metabolism by transporting pyruvate, the end-product of glycolysis, into the mitochondrial matrix. Recently, structur...