Better call chaperone [0.03%]
最好找个贴身男护卫来帮忙
Yunxing &#x;Stella&#x; Li
Yunxing &#x;Stella&#x; Li
Stefan A Harry,Chirag Vasavda,Adam Wahida et al.
Stefan A Harry et al.
Today, therapeutic drug discovery lies at the crossroads of mechanistic biochemistry and the rapidly growing fields of multi-omics and AI. How will traditionally reductionist biochemistry adapt to the increasing complexity of biological pro...
Sheetal Gandotra,Shee-Mei Lok,Jijie Chai et al.
Sheetal Gandotra et al.
Sebastian J Hofer,Ghada Alsaleh,Anna Katharina Simon
Sebastian J Hofer
Polyamines are ancient metabolites that support growth, translation, and autophagy. Zabala-Letona et al. reveal a new mode of action-'metabolic shielding'-in which polyamines protect phosphorylation motifs in spliceosomal factors. This work...
Madouc D Bergers,Tessa A Goté,Zachary Armstrong
Madouc D Bergers
Glycans are polymeric carbohydrate chains that often decorate proteins and lipids present on cell surfaces and in the extracellular space, thereby influencing cell interactions, immune responses, and host-microbiome relationships. Glycans a...
Ilinca I Ciubotariu,Damien B Wilburn,Gundula Bosch et al.
Ilinca I Ciubotariu et al.
Graduate training often emphasizes technical specialization over critical thinking and theories of knowledge, impeding the research enterprise. Here, we describe a new Ohio State University course on epistemology and research practices, ada...
Chengrui Hu,Yourong Pan,Chengxi Li
Chengrui Hu
Glycosphingolipids in cell identity: Biosynthesis, functions, and emerging tools [0.03%]
糖鞘脂在细胞身份的决定中的作用：生物合成、功能和新兴工具
Pavel Barahtjan,Nika Goršek,Jean Andrea Maillat et al.
Pavel Barahtjan et al.
Cell fate is shaped by external cues and intrinsic cellular states. While supracellular signals, such as growth factors, provide instructive guidance, emerging evidence highlights the role of cell-autonomous properties in modulating these r...
Cap in hand: giant viruses, stolen translation, and a road to endosymbiosis? [0.03%]
俯首称臣：巨病毒、窃取的转录和内共生的道路？
Nicholas W Hubbard,Nels C Elde
Nicholas W Hubbard
Fels et al. (2026) report that the giant DNA virus mimivirus encodes a complete, functional translation initiation complex, termed vIF4F, which replaces the host's own initiation machinery during infection, sustains viral protein synthesis ...
Aline M A Martins,John R Yates rd,Alysson R Muotri et al.
Aline M A Martins et al.