Michele Brischigliaro,Ahram Ahn,Seungwoo Hong et al.
Michele Brischigliaro et al.
Mitochondrial translation regulation enables precise control over the synthesis of hydrophobic proteins encoded by the organellar genome, orchestrating their membrane insertion, accumulation, and assembly into oxidative phosphorylation (OXP...
Decoding PETase diversity through global landscape profiling: toward superior enzymes for plastic recycling [0.03%]
通过全球景观分析解码PET酶的多样性：迈向更优越的塑料回收酶
Yoonjoo Seo,Na Wei
Yoonjoo Seo
A recent study by Seo, Hong, Park, et al. maps the global fitness landscape of PET-degrading enzymes, identifying superior PETases for plastic depolymerization. The engineered high-performance variant surpasses benchmarks under industrial c...
Joyce Ogidigo,Reena Kumari,Viraj R Sanghvi
Joyce Ogidigo
Fructosamine 3-kinase (FN3K) mitigates excessive protein glycation by phosphorylating and destabilizing fructosamines, preventing irreversible advanced glycation end-products (AGEs). Recent high-resolution structures of FN3K by Garg and On ...
Songtao Ye,Choon Leng So,Danfeng Cai
Songtao Ye
Cellular protein compartmentalization is essential for function, yet the mechanisms directing proteins to their correct destinations remain unclear. Recently, Kilgore, Chinn, Mikhael, and Mitnikov et al. introduced ProtGPS, an artificial in...
Pierre Rustin,Howard T Jacobs,Mügen Terzioglu et al.
Pierre Rustin et al.
It has long been established that heat represents a major part of the energy released during the oxidation of mitochondrial substrates. However, with a few exceptions, the release of heat is rarely mentioned other than as being produced at ...
Lin Cheng,Yanglu Wang,Jingyang Guan et al.
Lin Cheng et al.
Pluripotent stem cells hold great promise as an unlimited resource for regenerative medicine due to their capacity to self-renew and differentiate into various cell types. Chemical reprogramming using small molecules precisely regulates cel...
Jennifer Porat,Ryan A Flynn
Jennifer Porat
Much of our understanding of RNA-protein interactions, and how these interactions shape gene expression and cell state, have come from studies looking at these interactions in vitro or inside the cell. However, recent data demonstrates the ...
Understanding mitochondrial protein import: a revised model of the presequence translocase [0.03%]
理解线粒体蛋白质输入：前序列转位酶的修正模型
Naintara Jain,Agnieszka Chacinska,Peter Rehling
Naintara Jain
Mitochondrial function relies on the precise targeting and import of cytosolic proteins into mitochondrial subcompartments. Most matrix-targeted proteins follow the presequence pathway, which directs precursor proteins across the outer mito...
Jia Yao,Chunyang Xie,Aimin Yang
Jia Yao
Autophagy is an intracellular degradation system that delivers cytoplasmic materials to the lysosome. S-acylation, a reversible post-translational modification that attaches long-chain fatty acids to cysteine residues within proteins, has r...
Innovations in the electron transport chain fuel archaeal methane metabolism [0.03%]
电子传输链的创新推动了泉古菌的甲烷代谢过程
Blake E Downing,Dipti D Nayak
Blake E Downing
Methanogenic archaea (or methanogens) produce methane as a by-product of energy metabolism. Strategies for energy conservation differ across methanogens. Some lineages use an electron transport chain (ETC) with an endogenously produced hete...