The ins and outs of connexins and pannexins beyond the cell surface [0.03%]
细胞表面connexin和pannexin的那些事
Tania Martins-Marques,Maria Vasconcelos-Cardoso,Maria Isabel Geli et al.
Tania Martins-Marques et al.
Classically implicated in the transport of small molecules between neighboring cells or into the extracellular milieu, emerging evidence implicates connexins and pannexins in other noncanonical biological functions. Propelled by recent tech...
RNA processing in innate immunity: regulation by RNA-binding proteins [0.03%]
RNA结合蛋白在先天免疫中的功能及调控机制研究
Asmita Panthi,Kristen W Lynch
Asmita Panthi
RNA processing is an important but often overlooked process in determining protein expression. Alternative polyadenylation and regulated mRNA stability control the amount and duration of protein expression, while alternative splicing also c...
Tim S Veth,Nicholas M Riley
Tim S Veth
The heterogeneity of the glycoproteome and the challenges associated with quantifying its regulation in complex biological systems have hindered functional glycoproteomics. The deep quantitative glycoprofiling (DQGlyco) method recently deve...
Lucía Álvarez,Lucía Beatriz Chemes
Lucía Álvarez
Intrinsically disordered proteins (IDPs) exist as dynamic conformational ensembles the behavior of which challenges the tenets of the protein structure-function paradigm. In a new study, Newcombe, Due et al. reveal a striking continuum in s...
Histone variants: expanding the epigenetic potential of neurons one amino acid at a time [0.03%]
组蛋白变体：一次一个氨基酸地扩展神经元的表观遗传潜能
Bradley J Lukasak,Erica Korb
Bradley J Lukasak
Replication-independent histone variants play an essential role in postmitotic neurons. Here, we review how the subtle sequence differences of histone variants compared to their canonical counterparts underly neuronal function. We focus on ...
Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells [0.03%]
修饰作用的修饰——人类细胞中ADP核糖基化的泛素化
Karla L H Feijs-Žaja,Jonas Siefert,Roko Žaja
Karla L H Feijs-Žaja
Ubiquitination and ADP-ribosylation are protein post-translational modifications (PTMs) which influence diverse protein properties. In vitro work has indicated that ubiquitin can be ADP-ribosylated and vice versa, ADP-ribose ubiquitinated. ...
Plant steroids on the move: mechanisms of brassinosteroid export [0.03%]
植物激素的动态变化： brassinosteroid 输出机制
Zi-Liang Hu,Hong Wei,Linfeng Sun et al.
Zi-Liang Hu et al.
Brassinosteroids (BRs) are essential plant steroidal hormones that regulate growth and development. The recent discoveries of ATP-binding cassette subfamily B (ABCB) members, ABCB19 and ABCB1, as BR transporters highlight the significance o...
Monitoring subcellular NADP redox state with NAPstar biosensors [0.03%]
利用NAPstar生物传感器监测细胞器内NADP氧化还原状态
Jan-Ole Niemeier,Leticia Prates Roma,Jan Riemer et al.
Jan-Ole Niemeier et al.
Mayra A Borrero-Landazabal,Vanessa Linke,Agnieszka Chacinska
Mayra A Borrero-Landazabal
Lipids are emerging as functional players in mitochondrial protein import beyond constituting membranes. Cryo-electron microscopy structures of protein translocases such as translocase of the outer membrane (TOM) and insertases such as tran...
Understanding peptide hormones: from precursor proteins to bioactive molecules [0.03%]
从前体蛋白到生物活性分子：理解肽类激素
Laetitia Coassolo,Amanda Wiggenhorn,Katrin J Svensson
Laetitia Coassolo
Peptide hormones are fundamental regulators of biological processes involved in homeostasis regulation and are often dysregulated in endocrine diseases. Despite their biological significance and established therapeutic potential, there is s...