Advancing nanopore technology toward protein identification and sequencing [0.03%]
推进纳米孔技术向蛋白质识别和测序发展
Verena Rukes,Chan Cao
Verena Rukes
Proteins drive most cellular functions and are key players in diseases, yet proteomics still lags behind genomics due to the complexity, diversity, and dynamic nature of proteoforms. Nanopore technology - known for real-time, single-molecul...
Sajad Ahmad Najar,Rahul Bohra,Tina Mukherjee
Sajad Ahmad Najar
Recent work by Nedbalova et al. reframes the SAM transmethylation pathway as a biosensor and signaling hub, linking immune activation to systemic metabolic changes via adenosine export. Their compelling findings reveal a key mechanism by wh...
Tomer Kagan,Tal Laviv
Tomer Kagan
Jennifer L DuBois
Jennifer L DuBois
A recent report by Harlington et al. introduces SyoA, a cytochrome P450 enzyme that efficiently removes a methyl group from the S-subunits of lignin. Lignin is one of the most abundant forms of renewable carbon on Earth. Methyl removal is e...
Stephanie Rosswag de Souza,Elvan Böke,Gabriele Zaffagnini
Stephanie Rosswag de Souza
Cellular dormancy is characterized by a prolonged, reversible cell cycle arrest and absence of growth. Dormancy allows organisms to endure unfavorable environmental conditions and to maintain long-lived quiescent progenitor cells essential ...
Marie Sofie Møller,Anton Bleckert,Anna Jäckering et al.
Marie Sofie Møller et al.
Plastics, especially polyethylene terephthalate (PET), are vital in modern life, with global production exceeding 400 million tons annually. This extensive use has led to significant plastic waste pollution, highlighting the need for effect...
From disorder to order: cryo-EM reveals RNA-dependent remodeling of Nipah virus polymerase [0.03%]
从无序到有序：基于冷冻电镜的Nipah病毒聚合酶重编程研究
Rupesh Balaji Jayachandran,Max Renner
Rupesh Balaji Jayachandran
A flurry of recent structural studies have focused on the polymerase complex of the deadly zoonotic pathogen Nipah virus (NiV). These include a report by Sala et al. describing an RNA duplex-bound state. This structure constitutes a snapsho...
The metabolic code of ferroptosis: nutritional regulators of cell death [0.03%]
铁死亡的代谢密码：细胞凋亡的营养调控因素
Juliane Tschuck,Vera Skafar,José Pedro Friedmann Angeli et al.
Juliane Tschuck et al.
Ferroptosis is a distinctive form of regulated cell death driven by iron-dependent phospholipid peroxidation. Its initiation and suppression are finely tuned by metabolic pathways, transcription factors, and nuclear receptors that control l...
Marion Jespersen,Chris Greening,Leonard Ernst et al.
Marion Jespersen et al.
Hydrogenases allow microorganisms to consume and produce hydrogen gas (H2). Although most hydrogenases are oxygen (O2)-sensitive, recent studies show that bacteria and archaea produce diverse nickel-iron [NiFe]-hydrogenases that function in...
Harnessing the power of peptides: advances and collaborations in biochemistry [0.03%]
利用肽的力量：生物化学中的进展与合作
Laetitia Coassolo,Katrin J Svensson,Caitlin L Gare et al.
Laetitia Coassolo et al.