Felipe Muñoz-Guzmán,Luis F Larrondo
Felipe Muñoz-Guzmán
Circadian clocks maintain the correct period despite nutritional fluctuations, a property known as metabolic compensation (MC). In a recent report, Sárkány et al. reveal a conserved role for Ras guanine nucleotide exchange factor (RasGEF)...
The HIF axes in cancer: angiogenesis, metabolism, and immune-modulation [0.03%]
缺氧诱导因子轴在癌症中的作用：血管生成、代谢和免疫调节
Karen Acuña-Pilarte,Mei Yee Koh
Karen Acuña-Pilarte
The hypoxia-inducible factors (HIFs) are central transcriptional mediators of the cellular response to hypoxia. HIF activation typically drives a physiologically beneficial adaptive response to hypoxia. However, within solid tumors, the HIF...
Xinming Zhang,Yingying Zhu,Yuan Ma
Xinming Zhang
Cell-specific mitoproteomics reveals mitochondrial plasticity and applications [0.03%]
细胞特异性线粒体蛋白质组学揭示了线粒体的可塑性和应用价值
Domingos F M Neto,Rita de Cassia Monteiro-Batista,Adriano Nunes-Nesi et al.
Domingos F M Neto et al.
Understanding the tissue-specific mitochondrial proteome is essential for advancing understanding of plant biology. In a recent study, Boussardon et al. applied Isolation of Mitochondria Tagged in Specific Cell Types (IMTACT) to investigate...
Samuel Schwab,Yimin Hu,Birte Hernandez Alvarez et al.
Samuel Schwab et al.
Histones are fundamental chromatin-organizing proteins in eukaryotes and archaea, where they assemble into (hyper)nucleosomes that wrap DNA. Recent studies have expanded the known repertoire of histones, identifying new variants in both pro...
Carly K Schissel
Carly K Schissel
Installation of unnatural chemical motifs and structures into proteins in living cells is challenging. Recent work by Beyer et al. demonstrated programmable protein editing by installing two split intein pairs into a protein of interest, wh...
Mitochondrial tRNA processing: a neutral evolutionary ratchet innovation [0.03%]
线粒体tRNA加工：中性进化棘轮创新机制
Lien B Lai,Jane E Jackman,Charles J Daniels et al.
Lien B Lai et al.
Mitochondrial tRNA processing is a chronicle of molecular adaptability. The processing of structurally compromised tRNAs is unexpectedly rescued by a multienzyme complex shaped by constructive neutral evolution. This striking example of bio...
Tissue expansion enables proteomics at improved spatial resolution [0.03%]
组织扩张技术使蛋白质组学在更高的空间分辨率下成为可能
Zhen Dong,Wenhao Jiang,Tiannan Guo
Zhen Dong
Antoni Barrientos,Flavia Fontanesi,Pierre Rustin et al.
Antoni Barrientos et al.
CryoEM provides detailed insights into how VPS15 regulates VPS34 activity [0.03%]
单颗粒冷冻电镜解析VPS15调节VPS34活性的机制
Robyn Duttenhefner,Subeksha Subedi,Sangita C Sinha
Robyn Duttenhefner
Cook et al. show that the VPS15 pseudokinase domain binds GTP and sequesters its covalently-linked N-terminal myristate. Together, this enforces VPS15 conformations that interact with and stabilize inactive VPS34 kinase domain conformations...