Maria K Mateyak,Terri Goss Kinzy
Maria K Mateyak
Protein synthesis requires factors that are proposed to enhance discrete steps. Eukaryotic initiation factor eIF5A was initially thought to affect initiation; however, it was later shown to facilitate translation elongation at polyproline. ...
An Updated Translation [0.03%]
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Nicole Neuman
Nicole Neuman
Aishwarya Iyer,Ingrid Grummt
Aishwarya Iyer
Sinturel et al. demonstrate that feeding-fasting rhythms and light-dark cycles direct daily changes in liver mass and cell size. These feeding-fasting- and light-dark-driven diurnal fluctuations are controlled by an unconventional mechanism...
Paul Huter,Claudia Müller,Stefan Arenz et al.
Paul Huter et al.
Ribosomes that translate mRNAs lacking stop codons become stalled at the 3' end of the mRNA. Recycling of these stalled ribosomes is essential for cell viability. In bacteria three ribosome rescue systems have been identified so far, with t...
Thomas Lanyon-Hogg,Monica Faronato,Remigiusz A Serwa et al.
Thomas Lanyon-Hogg et al.
Post-translational attachment of lipids to proteins is found in all organisms, and is important for many biological processes. Acylation with myristic and palmitic acids are among the most common lipid modifications, and understanding rever...
Surinder Kumar,David B Lombard
Surinder Kumar
Recent studies have revealed the existence of a plethora of previously unknown protein acyl-lysine modifications, affecting the functions of targets involved in diverse cellular processes. A recent study from the Hirschey laboratory has pro...
David Pritchett,Akhilesh B Reddy
David Pritchett
There is growing evidence of reciprocal interactions between the endogenous circadian clock and subcellular redox pathways. Recently, researchers at the University of California unearthed another possible link between redox metabolism and t...
Surinder Kumar,David B Lombard
Surinder Kumar
Despite the fact that SIRT4 regulates important biological processes, its primary enzymatic activity has remained ambiguous. A recent study by Anderson, Huynh et al. has uncovered deacylase activities of SIRT4 towards newly described lysine...
Dieter Kressler,Ed Hurt,Jochen Baßler
Dieter Kressler
The biogenesis of eukaryotic ribosomes is a complicated process during which the transcription, modification, folding, and processing of the rRNA is coupled with the ordered assembly of ∼80 ribosomal proteins (r-proteins). Ribosome synthes...
Davide D&#x;Amico,Vincenzo Sorrentino,Johan Auwerx
Davide D&#x;Amico
Mitochondrial stress requires timely intervention to prevent mitochondrial and cellular dysfunction. Re-establishing the correct protein homeostasis is crucial for coping with mitochondrial stress and maintaining cellular homeostasis. The b...