Sidak Minocha,Marta Oliva-Santiago,Sampath Amitash Gadi et al.
Sidak Minocha et al.
Lesions on DNA threaten the integrity of replicating genomes, necessitating DNA damage tolerance mechanisms to bypass these lesions and ensure complete duplication of the genome. Lesion bypass by DNA polymerases can occur through either tra...
Claire F Dickson,Prabhjeet Phalora,David A Jacques
Claire F Dickson
The nuclear pore complex (NPC) facilitates macromolecular exchange between the cytoplasm and nucleus; the selective nature of which is vital to proper cell functioning. Many DNA and some RNA viruses must also access the host nucleus for suc...
LRRC8/VRAC chloride and metabolite channels in signaling and volume regulation [0.03%]
LRRC8/VRAC氯通道和代谢物通道在信号传导和体积调节中的作用
Fabian M B Thöne,Maya M Polovitskaya,Thomas J Jentsch
Fabian M B Thöne
Volume-regulated anion channels (VRACs) are almost ubiquitously expressed plasma membrane (PM) channels of vertebrate cells with roles in cell volume regulation and signaling. Besides conducting anions such as chloride, VRACs transport meta...
Fei Qu,Yuan Liu
Fei Qu
N6-methyladenosine (m6A) is the most abundant epitranscriptomic mark on mRNA and plays crucial roles in gene expression, cell differentiation, stress responses, and cancer and neurodegenerative diseases. Recent studies have further revealed...
Epic science [0.03%]
史诗般的科学
Jennifer L DuBois
Jennifer L DuBois
Science is not a list of facts in a textbook, but rather a living series of stories spanning the history of human thought and continuing to this day. Understanding how scientific consensus evolves helps mitigate distrust of research among t...
Camille V Goemans
Camille V Goemans
The gut microbiota harbors a vast array of enzymes, many with unknown functions. In a recent study, Probst et al. mined this ecosystem to identify potential defluorinating enzymes. Combining molecular dynamics, alanine scanning, and machine...
Molecular mimicry: ecology, evolution, and applications of doppelgänger peptides [0.03%]
分子模拟：拟态肽的生态、进化及应用
Thomas L Koch,Samuel D Robinson,Helena Safavi-Hemami
Thomas L Koch
Organisms engage in chemical interactions that drive cooperation, conflict, natural selection, and adaptation. Among these, doppelgänger peptides (molecular mimics of the endogenous hormones or neuropeptides of another organism) have evolv...
Murray Stewart
Murray Stewart
In eukaryotes, the separation of transcription from translation enables extensive mRNA processing (capping, splicing, and polyadenylation) before translation. This review focuses on recent work that provides considerable insight into how mR...
Anna Brennan,Taylor R Church,Seth S Margolis
Anna Brennan
The proteasome is an essential protein complex in all cells. Proteasomes have two main functions: protein degradation and peptide generation. While proteasome-dependent protein degradation removes proteins and is critical for cellular funct...
The ribosome ubiquitination code: fine-tuning translation under stress [0.03%]
核糖体泛素化密码子：应激条件下的精细翻译调节机制
Haleigh C Wooters,Neil C Nimmagadda,Alicia M Darnell et al.
Haleigh C Wooters et al.
It has become evident that a complex code of ribosome ubiquitination regulates protein synthesis, particularly in stress conditions. Ubiquitin is known largely for its role in protein stability; however, new high-throughput screening and ad...