Björn Rasch,Jan Born
Björn Rasch
According to a widely held concept, the formation of long-term memories relies on a reactivation and redistribution of newly acquired memory representations from temporary storage to neuronal networks supporting long-term storage. Here, we ...
Abnormal oscillatory synchronisation in the motor system leads to impaired movement [0.03%]
运动系统异常振荡同步导致运动障碍
P Brown
P Brown
Converging data suggest that abnormal synchronised oscillatory activity in the basal ganglia may contribute to bradykinesia in patients with Parkinson's disease. This synchrony preferentially occurs over 10-30 Hz, the so-called beta band. C...
Techniques for extracting single-trial activity patterns from large-scale neural recordings [0.03%]
大规模神经记录中提取单次试验活动模式的技术
Mark M Churchland,Byron M Yu,Maneesh Sahani et al.
Mark M Churchland et al.
Large, chronically implanted arrays of microelectrodes are an increasingly common tool for recording from primate cortex and can provide extracellular recordings from many (order of 100) neurons. While the desire for cortically based motor ...
Atsushi Miyawaki,Mark J Schnitzer
Atsushi Miyawaki
Alan Jasanoff
Alan Jasanoff
Functional imaging with MRI contrast agents is an emerging experimental approach that can combine the specificity of cellular neural recording techniques with noninvasive whole-brain coverage. A variety of contrast agents sensitive to aspec...
Ann Marie Craig,Wieland B Huttner
Ann Marie Craig
Integration of light-controlled neuronal firing and fast circuit imaging [0.03%]
集光控神经元放电与快扫描环路成像于一体的先进技术
Raag D Airan,Elbert S Hu,Ragu Vijaykumar et al.
Raag D Airan et al.
For understanding normal and pathological circuit function, capitalizing on the full potential of recent advances in fast optical neural circuit control will depend crucially on fast, intact-circuit readout technology. First, millisecond-sc...
Stephen J Smith
Stephen J Smith
To understand how a brain processes information, we must understand the structure of its neural circuits-especially circuit interconnection topologies and the cell and synapse molecular architectures that determine circuit-signaling dynamic...
The role of mu opioid receptor desensitization and endocytosis in morphine tolerance and dependence [0.03%]
μ型阿片受体脱敏和内吞作用在吗啡耐受和依赖中的作用
Lene Martini,Jennifer L Whistler
Lene Martini
Following activation, most G protein coupled receptors undergo regulation by a cascade of events that promote receptor desensitization and endocytosis. Following endocytosis, receptors can then be recycled to the plasma membrane, retained i...
Rapidly inducible, genetically targeted inactivation of neural and synaptic activity in vivo [0.03%]
快速诱发的、遗传靶向的活体神经元和突触失活技术
Dougal Tervo,Alla Y Karpova
Dougal Tervo
Inducible and reversible perturbation of the activity of selected neurons in vivo is critical to understanding the dynamics of brain circuits. Several genetically encoded systems for rapid inducible neuronal silencing have been developed in...