Visualizing circuits and systems using transgenic reporters of neural activity [0.03%]
利用转基因神经活动报告技术可视化电路和系统
Alison L Barth
Alison L Barth
Genetically encoded sensors of neural activity enable visualization of circuit-level function in the central nervous system. Although our understanding of the molecular events that regulate neuronal firing, synaptic function, and plasticity...
Haojiang Luan,Benjamin H White
Haojiang Luan
Methods for the selective and reproducible expression of genetically encoded tools in targeted subsets of cells are required to facilitate studies of neuronal development, connectivity, and function in living animals. In the absence of tech...
Nadine Gogolla,Ivan Galimberti,Pico Caroni
Nadine Gogolla
There is now conclusive evidence for widespread ongoing structural plasticity of presynaptic boutons and axon side-branches in the adult brain. The plasticity complements that of postsynaptic spines, but axonal plasticity samples larger vol...
Mark S Forman,John Q Trojanowski,Virginia M-Y Lee
Mark S Forman
Over the past decade, it has become clear that there is a significant overlap in the clinical spectrum of frontotemporal lobar degeneration and amyotrophic lateral sclerosis (ALS). The identification of TDP-43 as the major disease protein i...
Roles of odorant receptors in projecting axons in the mouse olfactory system [0.03%]
小鼠嗅觉系统中投射轴突上气味受体的作用
Takeshi Imai,Hitoshi Sakano
Takeshi Imai
In the mouse olfactory epithelium, there are about ten million olfactory sensory neurons, each expressing a single type of odorant receptor out of approximately 1000. Olfactory sensory neurons expressing the same odorant receptor converge t...
Fen-Biao Gao
Fen-Biao Gao
Dendrites exhibit unique cell type-specific branching patterns and targeting specificity that are crucially important for neuronal function and connectivity. Recent evidence indicates that highly complex transcriptional regulatory networks ...
Photoreceptor morphogenesis and retinal degeneration: lessons from Drosophila [0.03%]
光感受器的形态发生及视网膜退行性病变：果蝇中的研究教训
Elisabeth Knust
Elisabeth Knust
Cells exhibit an amazingly wide range of different forms, and in most cases the shape of a cell is crucial for performing its specific function(s). But how does a cell obtain its particular shape during development, how can the shape be ada...
Mikael Simons,Jacqueline Trotter
Mikael Simons
During nervous system development, oligodendroglia in the central nervous system (CNS) and Schwann cells in the peripheral nervous system (PNS) synthesise large amounts of specific proteins and lipids to generate myelin, a specialised membr...
Bevil R Conway,Margaret S Livingstone
Bevil R Conway
Artists try to understand how we see, sometimes explicitly exploring rules of perspective or color, visual illusions, or iconography, and conversely, scientists who study vision sometimes address the perceptual questions and discoveries rai...
Kenichi Ohki,R Clay Reid
Kenichi Ohki
Research on the functional anatomy of visual cortical circuits has recently zoomed in from the macroscopic level to the microscopic. High-resolution functional imaging has revealed that the functional architecture of orientation maps in hig...