Concise syntheses of enantiomerically pure protected 4-hydroxypyroglutamic acid and 4-hydroxyproline from a nitroso-cyclopentadiene cycloadduct [0.03%]
由硝基环戊二烯加成物合成光学纯保护的4-羟基吡咯谷氨酸和4-羟基脯氨酸的简洁方法
Weiqiang Huang,Marvin J Miller
Weiqiang Huang
O-TBS-protected methyl trans-4-hydroxypyroglutamate and methyl trans-4-hydroxyproline ester were synthesized from nitroso-cyclopentadiene Diels-Alder cycloadducts. Enzymatic resolution of the key intermediate, 4-amino-cyclopent-2-enol, prov...
A Diastereoselective Intramolecular Pauson-Khand Approach to the Construction of the BC Ring System in Tuberostemoninol [0.03%]
用于 Constructs BC 环系的白羊草素合成的对映选择性 Pauson-Khand 反应
Xiangna Jia,Robert M Williams
Xiangna Jia
Herein we describe an asymmetric approach to the synthesis of a BC-ring synthon in tuberostemoninol via an intramolecular Pauson-Khand reaction stereocontrolled by a commercially available chiral glycinate.
Synthesis of N-linked glycopeptides on solid support and their evaluation as protease substrates [0.03%]
固相合成N-连接糖肽及用作蛋白酶底物的评价
Mallesham Bejugam,Beatrice A Maltman,Sabine L Flitsch
Mallesham Bejugam
A range of glycopeptides containing protease cleavage sites were synthesized on solid support using Fmoc-based solid phase glycopeptide synthesis. The immobilized peptides were studied as substrates for the proteases chymotrypsin and thermo...
Benjamin W Gung,Derek T Craft,Jessica Truelove
Benjamin W Gung
A short synthesis of the enantiomer of the polyacetylenic natural product siphonodiol is described. The synthesis is based on the strategy of taking advantage of the hidden symmetry of the target molecule and minimizing the use of protectin...
Differentiation of chiral phosphorus enantiomers by P and H NMR spectroscopy using amino acid derivatives as chemical solvating agents [0.03%]
手性磷对映体的拆分——使用氨基酸衍生物作化学溶剂通过~31P和~1H核磁共振光谱法研究
Yingchun Li,Frank M Raushel
Yingchun Li
The ability of commercially available amino acid derivatives, especially Fmoc-Trp(Boc)-OH, to differentiate enantiomers of chiral phosphonates, phosphinates, phosphates, phosphine oxides, and phosphonamidates is demonstrated with (31)P, (13...
Synthesis of Polymer-supported Chiral Lithium Amide Bases and Application in Asymmetric Deprotonation of Prochiral Cyclic Ketones [0.03%]
固相手性锂酰胺碱的合成及其在环状酮去对映选择性脱质子化反应中的应用研究
Lili Ma,Paul G Williard
Lili Ma
Polymer-supported chiral amines were effectively prepared from amino acid derivatives and Merrifield resin. Treatment of polymer-supported amines with n-butyllithium gave the corresponding polymer-suppported chiral lithium amide bases, whic...
Fluorous 2-Chloropyridinium Salt (Mukaiyama Condensation Reagent) for Amide Formation Reactions [0.03%]
用于胺形成反应的全氟化合物2-氯吡啶𬭩盐（牧居山缩合试剂）
Tadamichi Nagashima,Yimin Lu,Michael J Petro et al.
Tadamichi Nagashima et al.
A new fluorous 2-chloropyridinium hexafluorophosphate was prepared as a modified Mukaiyama condensation reagent, and it was applied in amide formation reactions. Good to excellent purities of amides were obtained after fluorous solid-phase ...
Enantioselective synthesis of (2R,3R)- and (2S,3S)-2- [(3-chlorophenyl)-(2-methoxyphenoxy)methyl]morpholine [0.03%]
(2R,3R)-和(2S,3S)-2-[（3-氯苯基）-(2-甲氧基苯氧)]亚甲基吗啉的不对称合成
Wayne W Harding,Matthis Hodge,Zhixia Wang et al.
Wayne W Harding et al.
The enantioselective synthesis of the (R,R)- and (S,S)-enantiomers of 1 from commercially available 3-chlorocinnamic acid is reported. The Sharpless asymmetric epoxidation was used to establish the stereocenters in the synthesis of both ena...
Enantioselective radical reactions. Evaluation of nitrogen protecting groups in the synthesis of beta-amino acids [0.03%]
不对称自由基反应的设计合成及氮保护基的研究_beta-氨基酸的合成中的氮保护基的研究
Mukund P Sibi,Kalyani Patil
Mukund P Sibi
We have investigated the effect of nitrogen protecting groups in radical addition trapping experiments leading to beta(2)-amino acids. Of the three N-protecting groups examined, the phthalimido group was optimal with respect to both yields ...