Enantioselective synthesis of new oxazolidinylthiazolidines as enzyme inhibitors [0.03%]
新型oxazolidinylthiazolidines类酶抑制剂的不对称合成
Cecilia Saiz,Valentina Villamil,Mariano M González et al.
Cecilia Saiz et al.
The synthesis of new oxazolidinylthiazolidines bicycles, oxygen analogues of bisthiazolidines, also known as metallo-β-lactamase inhibitors is described. The reaction of β-aminoalcohols and 2,5-dihydroxy-1,4-dithiane led to oxazolidinylth...
Reassignment of the absolute configuration of plakinidone from the sponge consortium Plakortis halichondrioides-Xestospongia deweerdtae using a combination of synthesis and a chiroptical approach [0.03%]
结合合成和圆二色光谱法将来源于海绵共生体Plakortis halichondrioides-Xestospongia deweerdtae中plakinidone的绝对构型重新确定为原构相反构型
Carlos Jiménez-Romero,Joanna E Rode,Abimael D Rodríguez
Carlos Jiménez-Romero
Recent work by Wu et al. in connection with the first synthesis of the marine natural product plakinidone revealed that the most salient feature of its purported structure, a six-membered perlactone moiety, was in fact a five-membered lacto...
Synthesis of enantiopure 1,2-azido and 1,2-amino alcohols via regio- and stereoselective ring-opening of enantiopure epoxides by sodium azide in hot water [0.03%]
热的水中由叠氮钠开环对映体纯环氧树脂区域选择性和立体选择性合成1，2-叠氮和1,2-氨基醇
Hai-Yang Wang,Kun Huang,Melvin De Jesús et al.
Hai-Yang Wang et al.
A practical and convenient method for the efficient and regio- and stereoselective ring-opening of enantiopure monosubstituted epoxides by sodium azide under hydrolytic conditions is reported. The ring-opening of enantiopure styryl and pyri...
Enantiomeric impurities in chiral synthons, catalysts, and auxiliaries. Part 3 [0.03%]
手性合成子、催化剂和助剂中的对映异构体杂质。第3部分
Ke Huang,Zachary S Breitbach,Daniel W Armstrong
Ke Huang
The enantiomeric excess of chiral reagents used in asymmetric syntheses directly affects the reaction selectivity and product purity. In this work, 84 of the more recently available chiral compounds were evaluated to determine their actual ...
David M Hitt,Yamina Belabassi,Joyce Suhy et al.
David M Hitt et al.
Malathion, diethyl 2-[(dimethoxyphosphorothioyl)sulfanyl]butanedioate, is an organophosphate used to control insect pests. Malathion contains a diethyl succinate moiety that is a known functional group susceptible to desymmetrizing enzymes ...
Controlling stereoselectivity by enzymatic and chemical means to access enantiomerically pure (1 S,3 R)-1-benzyl-2,3-dimethyl-1,2,3,4-tetrahydroisoquinoline derivatives [0.03%]
通过酶法和化学选择控制获得(1S,3R)-1-苯甲基-2,3-二甲基-1,2,3,4-四氢异喹啉类衍生物的对映体纯度
Alejandro A Orden,Joerg H Schrittwieser,Verena Resch et al.
Alejandro A Orden et al.
A chemoenzymatic strategy for the synthesis of enantiomerically pure novel alkaloids (1S,3R)-1-benzyl-2,3-dimethyl-1,2,3,4-tetrahydroisoquinolines is presented. The key steps are the biocatalytic stereoselective reductive amination of subst...
Synthesis and Spectroscopic Correlation of the Diastereoisomers of 2,3-Dihydroxy-2,6,8-trimethyldeca-(4 Z, 6 E)-dienoic Acid: Implications for the Structures of Papuamides A-D and Mirabamides A-D [0.03%]
2,3-二羟基-2，6，8-三甲基癸-4Z，6E-二烯酸的非对映异构体的合成及其光谱关联：对Papuamide A-D和Mirabamide A-D结构的意义
Gurusankar Ramamoorthy,Cristina M Acevedo,Edgardo Alvira et al.
Gurusankar Ramamoorthy et al.
All 4 diastereomeric possibilities for the 2,3-dihydroxy-2,6,8-trimethyldeca-(4Z,6E)-dienoic acid (Dhtda) residue, found in the cyclic depsipeptide natural products papuamides A-D and mirabamides A-D, were stereoselectively synthesized usin...
A solution to the stereochemical problems posed by amaryllidaceae constituents using a highly syn-selective arylcuprate conjugate addition to γ-amino and γ-carbamato-α,β-enoates [0.03%]
一种解决石蒜科生物碱立体化学问题的新方法：高非对映选择性的芳基铜试剂与γ-氨基酸酯和γ-氨基甲酸酯-α, β-烯酸酯的共轭加成反应
Shiva K Rastogi,Alexander Kornienko
Shiva K Rastogi
Various substituted arylcuprates undergo stereocontrolled additions to L-serine-derived γamino- and γ-carbamato-α,β-enoates with high syn-selectivities. The stereochemical outcome of these reactions is fully consistent with the reductiv...
2-Acetamino-1,2-dideoxynojirimycin-lysine hybrids as hexosaminidase inhibitors [0.03%]
2-乙酰胺-1,2-二脱氧诺吉里明-赖氨酸杂化物作为己六氨基糖苷酶抑制剂的研究
Andreas J Steiner,Georg Schitter,Arnold E Stütz et al.
Andreas J Steiner et al.
Cyclisation by double reductive amination of 2-acetamino-2-deoxy-D-xylo-hexos-5-ulose with N-2 protected L-lysine derivatives provided 2-acetamino-1,2-dideoxynojirimycin derivatives without any observable epimer formation at C-5. Modificati...
Asymmetric multi-component reactions: convenient access to acyclic stereocenters and functionalized cyclopentenoids [0.03%]
不对称多组分反应：获得非环立体中心和功能性环戊烯类的便捷途径
Arun K Ghosh,Sarang S Kulkarni,Chun-Xiao Xu et al.
Arun K Ghosh et al.
Asymmetric multi-component reactions of optically active phenyl dihydrofuran, keto ester or N-tosyl imino ester, and allylsilane provided functionalized phenyl tetrahydrofurans with multiple stereogenic centers diastereoselectively. Cleavag...