Copper and clioquinol treatment in young APP transgenic and wildtype mice: effects on life expectancy, body weight and metal-ion levels [0.03%]
铜和氯喹醇对年轻APP转基因和野生型小鼠的治疗作用：对预期寿命、体重和金属离子水平的影响
Stephanie Schäfer,Frank-Gerald Pajonk,Gerd Multhaup et al.
Stephanie Schäfer et al.
Detlev Ganten,Gregg L Semenza,Christiane Nolte
Detlev Ganten
RNaseH2 mutants that cause Aicardi-Goutieres syndrome are active nucleases [0.03%]
导致Aicardi-Goutières综合征的RNaseH2突变体是具有活性的核酸内切酶
Fred W Perrino,Scott Harvey,Nadine M Shaban et al.
Fred W Perrino et al.
Mutations in the genes encoding the RNaseH2 and TREX1 nucleases have been identified in patients with Aicardi-Goutieres syndrome (AGS). To determine if the AGS RNaseH2 mutations result in the loss of nuclease activity, the human wild-type R...
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) overexpression in human colorectal cancer [0.03%]
人类结直肠癌中溶血磷脂酰胆碱酰基转移酶1(LPCAT1)过表达
Francisco Mansilla,Kerry-Ann da Costa,Shuli Wang et al.
Francisco Mansilla et al.
The alteration of the choline metabolite profile is a well-established characteristic of cancer cells. In colorectal cancer (CRC), phosphatidylcholine is the most prominent phospholipid. In the present study, we report that lysophosphatidyl...
Friedrich C Luft
Friedrich C Luft
Enhanced L1CAM expression on pancreatic tumor endothelium mediates selective tumor cell transmigration [0.03%]
增强的L1CAM在胰腺肿瘤内皮中的表达介导了选择性的肿瘤细胞迁移能力
Yasmin Issa,Daniel Nummer,Tobias Seibel et al.
Yasmin Issa et al.
L1 cell adhesion molecule (L1CAM) is a transmembrane cell adhesion molecule initially defined as a promigratory molecule in the developing nervous system that appears to be also expressed in some endothelial cells. However, little is known ...
Licochalcone A isolated from licorice suppresses lipopolysaccharide-stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice [0.03%]
从甘草中分离得到的茋黄素A抑制脂多糖刺激RAW264.7细胞的炎症反应及内毒素休克
Hyuck-Se Kwon,Jun Hong Park,Dae Hwan Kim et al.
Hyuck-Se Kwon et al.
Licochalcone A (LicA), a major phenolic constituent of the licorice species Glycyrrhiza inflata, exhibits various biological properties, including chemopreventive, anti-bacterial, and anti-spasmodic activity. We report that LicA inhibits in...
Homocysteine enhances cell proliferation in hepatic myofibroblastic stellate cells [0.03%]
高半胱氨酸可促进肝肌成纤维细胞的增值
Cheng-Gang Zou,Shun-Yu Gao,Yue-Shui Zhao et al.
Cheng-Gang Zou et al.
Homocysteine is an intermediate in sulfur amino acid metabolism, which takes place mainly in the liver. Recent studies have shown that hyperhomocysteinemia in patients and murine models develop hepatic fibrosis. To define mechanisms underly...
Expression of the endocannabinoid system in the bi-potential HEL cell line: commitment to the megakaryoblastic lineage by 2-arachidonoylglycerol [0.03%]
内源大麻素系统在双能HEL细胞系中的表达：2-花生四烯酸甘油促进巨核细胞谱系的分化
Maria Valeria Catani,Filomena Fezza,Samantha Baldassarri et al.
Maria Valeria Catani et al.
The role of the endocannabinoid system in haematopoietic cells is not completely understood. We investigated whether human erythroleukemia (HEL) cells were able to bind, metabolise and transport the main endocannabinoids, anandamide (AEA) a...
The A20 gene protects kidneys from ischaemia/reperfusion injury by suppressing pro-inflammatory activation [0.03%]
A20基因通过抑制促炎活化保护肾脏免受缺血/再灌注损伤
Jens Lutz,Le A Luong,Matthias Strobl et al.
Jens Lutz et al.
Ischaemia followed by reperfusion (I/R) can induce inflammation and injury and is a risk factor for delayed graft function and rejection of transplanted kidneys. Inflammation is regulated by NF-kappaB transcription factors which induce pro-...