Pharmacokinetic and pharmacodynamic interaction of siponimod (BAF312) and propranolol in healthy subjects [0.03%]
siponimod（BAF312）与普萘洛尔在健康志愿者中的药代动力学和药效学相互作用研究
Shibadas Biswal,Florine Polus,Parsar Pal et al.
Shibadas Biswal et al.
Objective: To evaluate the cardiac and pulmonary effects of siponimod (BAF312) and propranolol co-administration in healthy subjects. Methods: ...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2015 Oct;53(10):855-65. DOI:10.5414/CP202369 2015
Pharmacokinetics of fingolimod and metabolites in subjects with severe renal impairment: An open-label, single-dose, parallel-group study [0.03%]
一项开放标记、单剂量、平行组研究：有限制性严重肾损害患者的芬戈莫德及代谢产物的药代动力学
Olivier J David,Maxwell Pryce,Karin Meiser et al.
Olivier J David et al.
Objective: This study assessed the pharmacokinetics and tolerability of fingolimod and its metabolites in severe renal impairment and healthy subjects. Me...
Zhi-Bin Zhou,Xiao-Yu Yang,Xue Zhou et al.
Zhi-Bin Zhou et al.
Objective: To report a case of propofol-induced rhabdomyolysis. In this case, widespread myolysis was detected after induction of anesthesia. Case summary...
Effect of statins on the mortality and mechanical ventilation duration of acute lung injury patients: a meta-analysis of five randomized controlled trials [0.03%]
他汀类药物对急性肺损伤患者死亡率和机械通气时间影响的meta分析研究
Ping Yang,Dong-Sheng Hong,Jian Chen et al.
Ping Yang et al.
Background: Statins have been reported to exert anti-inflammatory effects, but the association between statins and acute lung injury (ALI) remains controversial. Thus, we performed a meta-analysis of all published randomi...
Pharmacokinetics of trantinterol and its metabolite in healthy elderly and young subjects [0.03%]
特拉莫替尔及其代谢产物在健康老年人和年轻人中的药动学研究
Jie Huang,Qi Pei,Hongyi Tan et al.
Jie Huang et al.
Objective: The aim of this study was to investigate and compare the pharmacokinetics of trantinterol and its active amphoteric carboxylic acid metabolite (1-carbonyl trantinterol) between the healthy elderly and young sub...
Isotretinoin conundrum: a randomized, openlabel, crossover study in Mexico to evaluate the bioavailability and bioequivalence of three pharmaceutical preparations of isotretinoin in healthy participants [0.03%]
异维甲酸难题：墨西哥健康参与者中用于评估三种异维A酸药剂制品生物利用度和生物等效性的随机、开放标记、交叉研究
Everardo Piñeyro-Garza,Magdalena Gómez-Silva,María Elena Gamino Peña et al.
Everardo Piñeyro-Garza et al.
Objective: The oral retinoid agent isotretinoin (13-cis-retinoic acid) is approved for the treatment of severe recalcitrant cystic acne. For registrational renewal of Oratane® in Mexico (isotretinoin; Laboratorios Dermat...
Ferulic acid alleviates Aβ25-35- and lipopolysaccharide-induced PC12 cellular damage: a potential role in Alzheimer's disease by PDE inhibition [0.03%]
丁香酸通过抑制PDE改善Aβ25-35和LPS诱导的PC12细胞损伤：阿尔兹海默病治疗潜力研究
Hao Huang,Zeng-Chun Ma,Yu-Guang Wang et al.
Hao Huang et al.
Objective: Phosphodiesterase (PDE) plays an important role in the pathogenesis of Alzheimer's disease (AD). Ferulic acid (FA) has a therapeutic benefit in the treatment of AD. We investigated whether this therapeutic effe...
Lysophosphatidylcholine attenuates melanoma cell adhesion and migration dependent on the degree of fatty acid saturation [0.03%]
溶血磷脂酰胆碱通过调节脂肪酸饱和度影响黑色素瘤细胞黏附和迁移
Thomas Ross,Sebastian Heuter,Martin Schlesinger et al.
Thomas Ross et al.
Once-daily dosing of levocabastine has comparable efficacy to twice-daily dosing in the treatment of allergic rhinitis assessed in an allergen challenge chamber [0.03%]
一次给药的莱伐卡朋与两次给药治疗过敏性鼻炎的疗效比较——在变应原激发室内的评估结果
Robert D Murdoch,Philippe Bareille,Diane Ignar et al.
Robert D Murdoch et al.
Objectives: To test the hypothesis that intranasal levocabastine (LEVO) may provide benefits as a oncedaily treatment in allergic rhinitis (AR), this non-inferiority study compared the effect at steady state of once- and ...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2015 Oct;53(10):811-8. DOI:10.5414/CP202389 2015
Ibuprofen lysinate, quicker and less variable: relative bioavailability compared to ibuprofen base in a pediatric suspension dosage form [0.03%]
伊布oprofen硫酸氢钠：与儿童悬液剂型的伊布oprofen相比，生物利用度更高且更稳定
Juan Manuel Ferrero-Cafiero,Ignasi Gich,Montse Puntes et al.
Juan Manuel Ferrero-Cafiero et al.
Objectives: To assess and compare the bioavailability of ibuprofen enantiomers (R and S) of two different pediatric suspensions: the first one with ibuprofen lysinate (Algidrin® Pediátrico, FARDI S.A., Barcelona, Spain)...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2015 Nov;53(11):972-9. DOI:10.5414/CP202368 2015