Successful use of infliximab and tacrolimus combination therapy in a patient with ulcerative colitis refractory to infliximab dose intensification plus azathioprine [0.03%]
英夫利西单抗剂量增强联合硫唑嘌呤治疗无效的溃疡性结肠炎患者成功使用英夫利西单抗和他克莫司组合疗法
Xavier Cortes,Joaquín Borrás-Blasco,Sergio Fernendez et al.
Xavier Cortes et al.
Objective: To report of a case successful use of infliximab (IFX) and tacrolimus (TAC) in a patient with ulcerative colitis (UC). Case summary: ...
Levothyroxine soft capsules demonstrate bioequivalent pharmacokinetic exposure with the European reference tablets in healthy volunteers under fasting conditions [0.03%]
左甲状腺素软胶囊在空腹健康受试者中的药代动力学暴露与欧洲参比片等效
Dina Al-Numani,Claudia Scarsi,Murray P Ducharme
Dina Al-Numani
Objective: To assess the bioequivalence (BE) potential under fasting conditions between levothyroxine soft capsules and the European reference tablet formulation. ...
A rapid, simple and sensitive method for the determination and bioequivalence study of transdermal fentanyl in human plasma using liquid chromatography-electrospray ionization tandem mass spectrometry [0.03%]
一种用人血浆液相色谱-电喷雾串联质谱法快速测定芬太尼贴剂中芬太尼及其生物等效性研究的方法
Shu-Qiao Cheng,Dong-Sheng Ouyang,Yong-Jun Tang et al.
Shu-Qiao Cheng et al.
Objective: Since the 1960s, fentanyl has been used to replace morphine nd other opioids due to its higher potency in the treatment of acute pain; since the 1990s, it has also been administrated to control chronic pain by ...
Pharmacokinetics and safety of paroxetine controlled-release tablet in healthy Chinese subjects: a single-dose three-period crossover study [0.03%]
华法林致出血的遗传学危险因素及评分系统研究进展
Rui Chen,Kai Shen,Pei Hu
Rui Chen
Objectives: To evaluate the pharmacokinetics of paroxetine controlledrelease tablets after single oral administrations and its safety profile in healthy Chinese subjects. ...
Clinical advantages including medication adherence with conversion to once-daily advagraf and sirolimus combination in stable kidney recipients [0.03%]
稳定肾移植受者转换为他克莫司和西罗莫司每日一次给药的联合方案带来的临床优势（包括改善用药依从性）
Heungman Jun,Myung Gyu Kim,Cheol Woong Jung
Heungman Jun
Purpose: For the past decades, the long-term results of renal allograft unchanged despite the development of immunology and drugs. The long-term use of a calcineurin-inhibitor (CNI) and medication nonadherence have become...
Evaluation of the effect of angiotensin converting enzyme inhibitors and angiotensin receptors blockers on aspirin antiplatelet effect [0.03%]
血管紧张素转换酶抑制剂和血管紧张素受体阻滞剂对阿司匹林抗血小板作用影响的评价
Sayer I Al-Azzam,Karem H Alzoubi,Omar F Khabour et al.
Sayer I Al-Azzam et al.
Objective: Cardiovascular disease (CVD) is one of the major burdens on societies and healthcare systems. Antiplatelet aspirin is used to prevent the occurrence or reoccurrence of cardiovascular events. However, studies ha...
Clinical and economic evaluation of pharmacists' contribution to patient care on a multi-disciplinary liver transplant team [0.03%]
药师在多学科肝移植团队中对患者护理的临床和经济效益评估
Young-Mi Ah,Ju-Yeun Lee,Mi-Ra Moon et al.
Young-Mi Ah et al.
Objectives: We aimed to describe and to evaluate the clinical and economic implications of pharmacists' interventions as members of the liver transplant team for hospitalized liver recipients. ...
Micro-optical prototyping of a surface acoustic wave-based point-of-care coagulation assay and first application in anticoagulated patients [0.03%]
基于表面声波的凝血检测芯片的微光学原型制作及在抗凝患者中的初步应用研究
Jochen Moll,Sascha Meyer dos Santos,Bernd Hils et al.
Jochen Moll et al.
Objective: Clinicians demand for methods to monitor effects of direct anticoagulants in the emergency setting. We recently described a coagulation assay based on surface acoustic waves (SAW) technology, which quantifies a...
Use of a dose-response model to guide future clinical trial of benvitimod cream to treat mild and moderate psoriasis [0.03%]
剂量反应模型引导苯维莫德乳膏治疗轻中度银屑病临床试验设计的研究
Yan-Nan Zang,Dao-Li Jiang,Lin Cai et al.
Yan-Nan Zang et al.
Objective: To investigate the time-dose-response relationship of benvitimod cream after topical administration in patients with mild and moderate psoriasis vulgaris for dosage regimen exploring. ...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2016 Feb;54(2):87-95. DOI:10.5414/CP202486 2016
Relative bioavailability, food effect, and safety of the single-dose pharmacokinetics of omecamtiv mecarbil following administration of different modified-release formulations in healthy subjects [0.03%]
不同改良释放剂型奥美卡尼单次给药的生物等效性、食物效应和安全性研究：健康受试者的药代动力学
Rameshraja Palaparthy,Christopher Banfield,Paco Alvarez et al.
Rameshraja Palaparthy et al.
Objective: Omecamtiv mecarbil is a novel small molecule that directly activates cardiac myosin and increases cardiac contractility without increasing cardiac myocyte intracellular calcium. This study evaluated the relativ...