Pain leads the way: the development of evidence-based medicine for pain relief [0.03%]
疼痛开道：基于证据的止痛医学的发展之路
Phil Wiffen,Andrew Moore
Phil Wiffen
This paper describes the development of evidence based methods in pain medicine since the 1980s at the Pain Research Department of the Nuffield Department of Clinical Neurosciences, Oxford University. Pain medicine can be said to have led t...
Bioequivalence and food effect assessment for vildagliptin/metformin fixed-dose combination tablets relative to free combination of vildagliptin and metformin in Japanese healthy subjects [0.03%]
维格列汀/二甲双胍固定剂量复方制剂与单方药物在健康受试者中的生物等效性和食物效应评估研究
Sachiko Mita,Shripad D Chitnis,Kenneth Kulmatycki et al.
Sachiko Mita et al.
Objective: To assess the bioequivalence of vildagliptin/metformin fixeddose combination (FDC) tablets (50/250 mg and 50/500 mg) to free combinations of vildagliptin and metformin and the effect of food on the pharmacokine...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2016 Apr;54(4):305-14. DOI:10.5414/CP202522 2016
Treatment with everolimus for a patient with systemic metastatic breast cancer results in severe pulmonary injury: a case report [0.03%]
依维莫司致系统性转移乳腺癌患者严重肺损伤1例报告
Meng Xiangying,Wang Tao,Wu Shikai et al.
Meng Xiangying et al.
Everolimus has been used in patients with hormone receptor-positive breast cancer. This study reports that treatment with everolimus alone induced severe pulmonary injury in a patient with systemic metastatic breast cancer. A 58-yearold wom...
High prevalence of self-medication practices among medical and pharmacy students: a study from Jordan [0.03%]
约旦医学和药学专业学生自我药物治疗行为的高发生率
Mohammad J Alkhatatbeh,Qais Alefan,Mohammad A Y Alqudah
Mohammad J Alkhatatbeh
Objective: To assess self-medication practices and to evaluate the impact of obtaining medical knowledge on self-medication among medical and pharmacy students at Jordan University of Science and Technology. ...
Pharmacokinetics of fixed-dose combinations of empagliflozin/metformin compared with individual tablets in healthy subjects [0.03%]
健康受试者中恩格列净/二甲双胍固定剂量复方制剂与单药片剂的药代动力学比较研究
Christina Rojas,Jasmin Link,Thomas Meinicke et al.
Christina Rojas et al.
Objective: To compare the pharmacokinetics of fixed-dose combination (FDC) tablets of empagliflozin/metformin with individual tablets taken together. Meth...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2016 Apr;54(4):282-92. DOI:10.5414/CP202425 2016
Effects of vitamin D on blood pressure in patients with type 2 diabetes mellitus [0.03%]
维生素D对2型糖尿病患者血压的影响
Kyeong Ju Lee,Yu Jeung Lee
Kyeong Ju Lee
Purpose: Previous studies have suggested that vitamin D supplementation may decrease blood pressure in patients with type 2 diabetes, although conflicting results have been reported. The purpose of this meta-analysis was ...
Population pharmacokinetics of aripiprazole in healthy Korean subjects [0.03%]
阿立哌唑在健康韩国人中的群体药代动力学研究
Ji-Young Jeon,Soo-Wan Chae,Min-Gul Kim
Ji-Young Jeon
Objective: Aripiprazole is widely used to treat schizophrenia and bipolar disorder. This study aimed to develop a combined population pharmacokinetic model for aripiprazole in healthy Korean subjects and to identify the s...
Antifungal effects of undecylenic acid on the biofilm formation of Candida albicans [0.03%]
月桂烯酸对白色念珠菌生物被膜形成的抗真菌作用
Dongmei Shi,Yaxin Zhao,Hongxia Yan et al.
Dongmei Shi et al.
Undecylenic acid can effectively control skin fungal infection, but the mechanism of its fungal inhibition is unclear. Hyphal growth of Candida albicans (C. albicans) and biofilm formation have been well recognized as important virulence fa...
Population pharmacokinetics of inhaled fluticasone furoate and vilanterol in adult and adolescent patients with asthma [0.03%]
成人及青少年哮喘患者的布地奈德福莫特罗吸入剂群体药代动力学研究
Ann Allen,Sarah Siederer,Shuying Yang
Ann Allen
Objectives: Population pharmacokinetic (PK) methods were used to characterize the PK of fluticasone furoate (FF) and vilanterol (VI) in patients with asthma following once daily inhaled FF/VI and FF and to identify signif...
Alternative methods for CYP2D6 phenotyping: comparison of dextromethorphan metabolic ratios from AUC, single point plasma, and urine [0.03%]
CYP2D6表型的替代方法：通过AUC、单时间点血浆和尿液代谢比比较右美沙芬的代谢比例
Rui Chen,Haotian Wang,Jun Shi et al.
Rui Chen et al.
Purpose: CYP2D6 is a high polymorphic enzyme. Determining its phenotype before CYP2D6 substrate treatment can avoid dose-dependent adverse events or therapeutic failures. Alternative phenotyping methods of CYP2D6 were com...