Persistence with antidepressant drugs in patients with dementia: a retrospective database analysis [0.03%]
抑郁症伴发痴呆患者抗抑郁药物的维持治疗：基于数据库的回顾性分析研究
Anke Booker,Jens Bohlken,Michael A Rapp et al.
Anke Booker et al.
Background: The aims of the present study are to determine what proportion of patients with dementia receives antidepressants, how long the treatment is administered, and what factors increase the risk of discontinuation....
Association of TNFSF4 (rs3850641) gene polymorphisms and coronary heart disease: an evidence-based meta-analysis [0.03%]
TNFSF4基因多态性与冠心病的关联：基于证据的meta分析
Yu Fu,Wenbin Huang,Dongmei Jin et al.
Yu Fu et al.
Objective: To clarify the effects of TNFSF4 (rs3850641) polymorphisms on coronary heart disease (CHD) risk. Method: Published literatur...
The role of 18F-FDG PET/CT in infectious endocarditis: a systematic review and meta-analysis [0.03%]
18F-FDG PET/CT在感染性心内膜炎中作用的系统评价和 Meta 分析
Jinzhu Yan,Chao Zhang,Yuming Niu et al.
Jinzhu Yan et al.
Purpose: To systematically review and conduct a meta-analysis of the available evidence for PET/CT using 18F-fluorodeoxyglucose as tracers in the imaging of infectious endocarditis (IE). ...
Relative bioavailability between two teriparatide formulations in healthy volunteers [0.03%]
健康志愿者中特立帕肽两种剂型间的相对生物利用度研究
Javier Farías,Guillermo A Keller,Mariana Papouchado et al.
Javier Farías et al.
Objective: To compare the pharmacokinetics, relative bioavailability (RB), immunogenicity, and safety after a single dose of test or reference formulation of teriparatide in healthy human volunteers in order to demonstrat...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2016 Aug;54(8):649-56. DOI:10.5414/CP202562 2016
Bioequivalence assessment of ambroxol orally-disintegrating tablet after a single oral-dose administration to healthy volunteers [0.03%]
氨溴索口溶片单次给药的健康受试者生物等效性研究
Yaojun Ni,Lili Hou,Liang Chen et al.
Yaojun Ni et al.
Objective: In this study, a modified LC-MS/MS method was used to determine plasma ambroxol concentration and thereby examine the bioequivalence of two ambroxol medications among healthy Chinese male volunteers. ...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2016 May;54(5):399-404. DOI:10.5414/CP202527 2016
Population pharmacokinetic-pharmacodynamic (PopPK/PD) modeling of risperidone and its active metabolite in Chinese schizophrenia patients [0.03%]
中国精神分裂症患者利培酮和其活性代谢产物的群体药动学-药效学（PopPK/PD）研究模型
Shuangmin Ji,Dewei Shang,Kehua Wu et al.
Shuangmin Ji et al.
Purpose: Risperidone is a second-generation antipsychotic agent commonly used in the treatment of ~ 31.1% of schizophrenia patients in China, it is the most commonly-prescribed antipsychotic agent. Despite the abundant us...
Prescribed drugs and polypharmacy in healthcare service users in South Korea: an analysis based on National Health Insurance Claims data [0.03%]
基于国民健康保险索赔数据的韩国医疗服务使用者的处方药和多重用药分析
Hae-Young Park,Hyun-Nam Ryu,Mi Kyong Shim et al.
Hae-Young Park et al.
Objective: This study was conducted to analyze and compare the exposure to individually prescribed drugs and the prevalence of polypharmacy according to age group and concomitant disease in South Korea. ...
Population pharmacokinetics of zonisamide after oral administration in healthy Chinese volunteers [0.03%]
口服氨磺必利在健康中国受试者中的群体药代动力学研究
Xuewen Qiu,Qing Dai,Fengjun Sun et al.
Xuewen Qiu et al.
To develop a population-based pharmacokinetic model for the oral antiepileptic drug zonisamide using a cohort of healthy (nonepileptic) subjects and evaluate the effect of individual factors on the pharmacokinetics of zonisamide. 30 young a...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2016 May;54(5):362-8. DOI:10.5414/CP202104 2016
Bioavailability, safety and immunogenicity of biosimilar infliximab (BOW015) compared to reference infliximab [0.03%]
生物类似药类克BOW015与原研类克的生物利用度、安全性和免疫原性的比较研究
John Lambert,Michael Wyand,Cheryl Lassen et al.
John Lambert et al.
Objectives: To compare the single-dose pharmacokinetics (PK), safety, and immunogenicity of the biosimilar infliximab (BOW015) to reference infliximab (rIFX) in healthy volunteers and to establish bioequivalence. ...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2016 Apr;54(4):315-22. DOI:10.5414/CP202530 2016
Analysis of silent information regulator 1 (SIRT1) gene polymorphisms in antituberculosis- drug-induced hepatotoxicity in a prospective cohort study [0.03%]
静寂信息调节因子1(SIRT1)基因多态性与抗结核药物肝毒性关联的前瞻性队列研究分析
Yu Wang,Xiu-Ying Yan,Jing-Can Wu et al.
Yu Wang et al.
Objective: Antituberculosisdrug-induced hepatotoxicity (ATDH) is a common and sometimes serious side effect related to tuberculosis (TB) treatment. A number of risk factors and host genetics contribute to the development ...