Lichenoid drug eruption caused by imatinib mesylate in a Chinese patient with gastrointestinal stromal tumor [0.03%]
中国胃肠道间质瘤患者服用甲磺酸伊马替尼所致类扁平苔藓型药物疹
Jing-Ru Luo,Xiao-Jun Xiang,Jian-Ping Xiong
Jing-Ru Luo
Imatinib mesylate, the first agent approved for the treatment of unresectable or metastatic gastrointestinal stromal tumor, is a tyrosine kinase inhibitor targeting (KIT) and the platelet-derived growth factor receptor-α and -β. However, ...
Isavuconazole absorption following oral administration in healthy subjects is comparable to intravenous dosing, and is not affected by food, or drugs that alter stomach pH [0.03%]
伊沙康唑口服和静脉给药的吸收情况相当且不受食物以及胃pH值调节药物的影响——一项健康志愿者试验的结果
Anne Schmitt-Hoffmann,Amit Desai,Donna Kowalski et al.
Anne Schmitt-Hoffmann et al.
Objective/methods: Two openlabel, single-dose, randomized crossover studies and one open-label, multiple-dose, parallel group study in healthy volunteers were conducted with the prodrug, isavuconazonium sulfate, to determ...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2016 Aug;54(8):572-80. DOI:10.5414/CP202434 2016
Barry G Woodcock
Barry G Woodcock
Editorial
The effects of apremilast on the QTc interval in healthy male volunteers: a formal, thorough QT study [0.03%]
一项在健康男性志愿者中进行的阿普斯特对QTc间期影响的正式全面研究
Maria Palmisano,Anfan Wu,Mahmoud Assaf et al.
Maria Palmisano et al.
Objective: This study was conducted to evaluate the effect of apremilast and its major metabolites on the placebocorrected change-from-baseline QTc interval of an electrocardiogram (ECG). ...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2016 Aug;54(8):613-21. DOI:10.5414/CP202555 2016
Role of oral propranolol in the treatment of infantile subglottic hemangioma [0.03%]
口服普萘洛尔治疗婴幼儿声门下血管瘤的疗效及相关因素分析
Xiao-Yan Li,Ying Wang,Lei Jin et al.
Xiao-Yan Li et al.
Objective: To determine the efficacy of oral propranolol for the treatment of infantile subglottic hemangioma. Methods: 17 children (13...
Prediction of fetal ductus arteriosus constriction by systemic and local dermatological formulations of NSAIDs based on PK/PD analysis [0.03%]
基于PK / PD分析的系统和局部皮肤病学非甾体抗炎药制剂对预测胎儿动脉导管收缩的效果
Shingo Tanaka,Satoko Hori,Hiroki Satoh et al.
Shingo Tanaka et al.
Aim: Use of nonsteroidal antiinflammatory drugs (NSAIDs) during the final trimester of pregnancy can cause fetal toxicity, such as ductus arteriosus (DA) constriction. The aim of this study was to predict quantitatively t...
Clinical pharmacist interventions on a Chinese neurology ward: a 2-year service evaluation [0.03%]
临床药师在中国神经内科病房中的干预措施——一项为期两年的服务评估研究
Yunzhen Hu,Meiling Cao,Danhua Xu et al.
Yunzhen Hu et al.
A prospective observational study of clinical pharmacist interventions was conducted over a 2-year period from November 2012 to October 2014 to evaluate the clinical activity of pharmacists in the care they provide to patients and to promot...
Effects of conopeptide-containing venom from seven species of Conidae gastropoda on the chick biventer-cervicis nerve-muscle assessed using the ConoServer database [0.03%]
基于ConoServer数据库的七种箭石螺科海蜗牛毒液中康宁智肽对鸡颈椎双腹肌神经肌肉的影响
Elizabeth Brown,Edward L K Masinde,Barry G Woodcock
Elizabeth Brown
Background: Conotoxins in the venom of marine gastropods (genus Conus, family Conidae) have been incriminated in fatal human stingings. Conotoxins are peptides (conopeptides) which target specific classes of ion channels ...
Human injuries and fatalities due to venomous marine snails of the family Conidae [0.03%]
有毒海洋锥螺所致的人体伤害及死亡事件
Alan J Kohn
Alan J Kohn
Objective: This paper provides the first compilation in more than 30 years of human injuries and fatalities from envenomation by marine gastropod molluscs of the predominantly tropical family Conidae. It seeks to apply re...
Integrative Western and Traditional Chinese Medicine service model for low back pain [0.03%]
整合的西医和中医服务模式用于治疗腰痛
Regina W S Sit,Wendy Wong,Sheung Wai Law et al.
Regina W S Sit et al.
Low back pain (LBP) is a common, costly, and debilitating condition that creates a heavy socioeconomic burden on the global health care systems. In Western Medicine (WM), the treatment goals are to relieve pain, reduce disability, and enhan...