The rs662 polymorphism of paraoxonase 1 affects the difference in the inhibition of butyrylcholinesterase activity by organophosphorus pesticides in human blood [0.03%]
人血浆中paraoxonase 1基因多态性影响有机磷农药对胆碱酯酶抑制作用的差异研究
Dae Cheol Nam,Yu Mi Ha,Min Kyu Park et al.
Dae Cheol Nam et al.
Objectives: Organophosphorus pesticides (OPs) are a human health hazard. OPs inhibit acetylcholinesterase (AChE) at nerve endings and accumulate acetylcholine (ACh) at these sites. High levels of ACh and long exposure pro...
Karel Allegaert,John N van den Anker
Karel Allegaert
Inadequate pain management but also inappropriate use of analgesics in early infancy has negative effects on neurodevelopmental outcome. As a consequence, neonatal pain management is still in search for the Holy Grail. At best, effective pa...
Effect of ABCB1 rs12720464 and rs1055302 polymorphisms in Chinese patients on the time course of action of rocuronium administered as a single dose [0.03%]
ABCB1基因rs12720464和rs1055302多态性对中国单次剂量注射罗库溴铵患者药效学时间过程的影响
Tian-long Qi,Yin-hui Zhou,Jing-jing Yuan et al.
Tian-long Qi et al.
Objective: To determine whether ABCB1 gene polymorphisms affect the time course of action of rocuronium in Chinese patients. Methods: T...
Effects of pretreatment with different doses of cisatracurium on succinylcholine-induced fasciculations [0.03%]
不同剂量顺式阿曲库铵预处理对琥珀胆碱引起的肌颤影响的实验研究
Zhuan Zhang,Dong-sheng Zhang,Wei Sui et al.
Zhuan Zhang et al.
Objective: To compare the effects of different doses of cisatracurium pretreatment on succinylcholine-induced fasciculations. Methods: ...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2016 Jun;54(6):426-32. DOI:10.5414/CP202531 2016
Compartmental approach to assess bioequivalence compared to the noncompartmental approach [0.03%]
compartmental法与非compartmental法评价生物等效性的比较研究
Sung Eun Kim,Renhua Zheng,Dongwoo Kang et al.
Sung Eun Kim et al.
Objective: The objective of this study is to evaluate the relative performance of individual or population compartmental analysis (ICA or PCA) vs. noncompartmental analysis (NCA) in estimating the systemic exposures of dr...
Population pharmacokinetics of IND/GLY (indacaterol/glycopyrronium) in COPD patients [0.03%]
用于慢性阻塞性肺病患者的IND / GLY（茚达特罗/格隆溴铵）群体药代动力学
Ivan Demin,Christian Bartels,Gordon Graham et al.
Ivan Demin et al.
Objective: Indacaterol/glycopyrronium (IND/GLY) is a fixed-dose combination (FDC) of indacaterol, an inhaled long-acting β2-agonist (LABA), and glycopyrronium, an inhaled long-acting muscarinic antagonist (LAMA), develop...
Pharmacokinetic properties and bioequivalence of spironolactone tablets in fasting and fed healthy Chinese male subjects [0.03%]
空腹及餐后健康中国男性受试者体内的螺内酯片药代动力学性质及生物等效性研究
Zhi-hua Li,Yang Deng,Hua-lin Cai et al.
Zhi-hua Li et al.
Background and purpose: Spironolactone is a potassium-sparing diuretic and is a competitive antagonist of aldosterone, which is widely used in the treatment of primary aldosteronism, essential hypertension, congestive car...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2016 Jun;54(6):455-61. DOI:10.5414/CP202543 2016
Comparative bioavailability of two tablet formulations of emtricitabine/tenofovir in healthy, fasting volunteers: a single-dose, randomized-sequence, open-label crossover study [0.03%]
恩曲他滨/替诺福韦两种片剂型药物在健康空腹受试者中的生物等效性：一项单次给药、随机顺序、开放标签交叉试验
Guillermo A Keller,Paola Czerniuk,Roberto Angel Bertuola et al.
Guillermo A Keller et al.
Objective: To evaluate the relative bioavailability of a new formulation of emtricitabine (EMT) 200 mg and tenofovir disoproxil fumarate (TNF) 300 mg and to compare with reference formulation to meet regulatory criteria i...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2016 Oct;54(10):825-34. DOI:10.5414/CP202540 2016
Prevalence of overweight in schizophrenia patients in Asia: findings of the research on Asian psychotropic prescription patterns (REAP) study [0.03%]
亚洲精神药物处方研究(REAP)计划在亚洲的重性精神病患者中的超重患病率的研究发现
Fei Wang,Yu-Tao Xiang,Gabor S Ungvari et al.
Fei Wang et al.
Objective: This study examined the proportion of overweight in schizophrenia inpatients in selected Asian countries and territories and its independent demographic and clinical correlates. ...
Bioequivalence and food effect study of enteric-coated mesalazine tablets in healthy Chinese volunteers by HPLC-ESI-MS/MS [0.03%]
高效液相色谱串联质谱法测定复方恩格列净片的药代动力学及食物效应研究报告
Zhao-hui Guo,Yang Deng,Hua-lin Cai et al.
Zhao-hui Guo et al.
Objective: To establish a developed HPLC-ESI-MS/MS method for simultaneous determination of mesalazine (5-ASA) and its major metabolite N-Ac-5-ASA in human plasma and to investigate bioequivalence of two enteric-coated me...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2016 Jun;54(6):484-94. DOI:10.5414/CP202517 2016