Safety and effectiveness of antifungal prophylaxis in preventing fungal infection after liver transplantation: a meta-analysis of randomized clinical trials [0.03%]
预防性抗真菌治疗在预防肝移植术后真菌感染中的有效性和安全性：随机对照试验的Meta分析研究
Tonghai Xing,Lin Zhong,Zhihai Peng
Tonghai Xing
Background: Fungal infections are widely recognized as a complication of liver transplantation, and their prevention and treatment are a challenge for clinicians. ...
Acetylsalicylic acid (ASA) - How much, how often, and when? A clinical-pharmacological perspective [0.03%]
乙酰水杨酸（阿司匹林）的用量、用法和用药时间：临床药理学观点
Dieter Loew,Gustav G Belz
Dieter Loew
The dose of acetylsalicylic acid (ASA) commonly used in the prevention and treatment of arteriosclerotic angiopathies is equal to or less than 100 mg daily. This choice of dose is predominantly based on molecular-pharmacological findings sh...
Overuse of proton pump inhibitors for stress ulcer prophylaxis in Jordan [0.03%]
约旦压力性溃疡预防用质子泵抑制剂过度使用
Mohammad A Y Alqudah,Sayer Al-Azzam,Karem Alzoubi et al.
Mohammad A Y Alqudah et al.
Objective: To determine the frequency of inappropriate proton pump inhibitor (PPI) prescriptions during hospitalization for stress ulcer prophylaxis on the general medical ward in a tertiary Jordanian hospital. ...
Prolonged effects of miconazole oral gel on warfarin anticoagulation even after treatment withdrawal [0.03%]
克霉唑口服凝胶对华法林抗凝的长期影响甚至在停止治疗后依然存在
Satoshi Murakami,Akihiro Tanaka,Keiko Ido et al.
Satoshi Murakami et al.
Objective: We investigated the effect of terminating miconazole oral gel (MOG) treatment on the anticoagulant activity of warfarin by evaluating changes in international normalized ratio levels (INR). ...
Construction of a database for published phase II/III drug intervention clinical trials for the period 2009-2014 comprising 2,326 records, 90 disease categories, and 939 drug entities [0.03%]
一个包含2009年至2014年发表的II/III期药物干预临床试验数据集（2326条记录，90种适应症和939个药物实体）的构建工程项目
Sohyun Jeong,Nayoung Han,Boyoon Choi et al.
Sohyun Jeong et al.
Objectives: To construct a database of published clinical drug trials suitable for use 1) as a research tool in accessing clinical trial information and 2) in evidence-based decision-making by regulatory professionals, cl...
Population pharmacokinetic characteristics of sirolimus in healthy Chinese subjects and renal transplant patients [0.03%]
他克莫司在健康受试者和肾移植患者中的群体药代动力学特征
Miao Wang,Bao-ling Duan,Yin-jin Yuan et al.
Miao Wang et al.
Aim: To identify the factors affecting the pharmacokinetics (PKs) of sirolimus in healthy Chinese subjects and renal transplant patients. Methods: ...
Evolocumab and alirocumab: exploring original procurement models to manage the reimbursement of these innovative treatments [0.03%]
依洛尤单抗和阿利纽单抗：探索原始采购模式以管理这些创新疗法的报销问题
Andrea Messori
Andrea Messori
Background: PCSK9 inhibitors (evolocumab and alirocumab) pose a challenge of sustainability because the potential patients are extremely numerous and the budget impact at the drugs' full price would be prohibitive. We hav...
Warfarin dose requirements with different genotypes of CYP2C9 and VKORC1 for patients with atrial fibrillation and valve replacement [0.03%]
不同基因型的华法林剂量需求：房颤和瓣膜置换患者的CYP2C9和VKORC1的影响
Weirong Chen,Luhua Wu,Xin Liu et al.
Weirong Chen et al.
Aims: To investigate whether genetic variants of CYP2C9 and VKORC1 have different effects on the dose of warfarin in 180 Han Chinese patients who were recruited from the Fu Wai Hospital. All were on maintenance treatment ...
Warfarin dose requirements with different genotypes of CYP2C9 and VKORC1 for patients with atrial fibrillation and valve replacement [0.03%]
不同基因型的华法林剂量需求-房颤和瓣膜置换患者的CYPC9和VKORC1
Weirong Chen,Luhua Wu,Xin Liu et al.
Weirong Chen et al.
Aims: To investigate whether genetic variants of CYP2C9 and VKORC1 have different effects on the dose of warfarin in 180 Han Chinese patients who were recruited from the Fu Wai Hospital. All were on maintenance treatment ...
Vincristine-induced paralytic ileus during induction therapy of treatment protocols for acute lymphoblastic leukemia in adult patients [0.03%]
成人急性淋巴细胞白血病诱导治疗中长春新碱致麻痹性肠梗阻
Takeo Yasu,Nobuhiro Ohno,Toyotaka Kawamata et al.
Takeo Yasu et al.
Vincristine (VCR) is an important drug used in the treatment of acute lymphoblastic leukemia (ALL). VCR-induced neurotoxicity can manifest as peripheral neuropathy, constipation, or paralytic ileus. While there are some case reports describ...