Evaluation of the area under the curve of enteric-coated mycophenolate sodium using a limited sampling strategy in Chinese kidney transplant recipients [0.03%]
评估拉米夫定有限样本策略在中国肾移植受者中的曲线下面积
Hongfeng Huang,Xi Yao,Jianyong Wu et al.
Hongfeng Huang et al.
Aims: To investigate the area under the curve (AUC) of mycophenolic acid (MPA) in adult Chinese renal allograft recipients receiving concomitant enteric-coated mycophenolate sodium (EC-MPS) and cyclosporine (CsA) during t...
Pharmacokinetics and food-effect of fosdagrocorat (PF-04171327), a dissociated agonist of the glucocorticoid receptor, in healthy adult Caucasian and Japanese subjects [0.03%]
氟达可替特（PF-04171327）在健康成年白人和日本受试者中的药代动力学及饮食影响研究
So Miyoshi,Judith Hey-Hadavi,Makoto Nagaoka et al.
So Miyoshi et al.
Objective: Fosdagrocorat (PF-04171327) is a pro-drug form of PF-00251802, a dissociated agonist of the glucocorticoid receptor, under investigation for the treatment of rheumatoid arthritis. This study investigates the ph...
Circadian pharmacokinetics and limited sampling strategy of everolimus in heart transplant patients [0.03%]
心脏移植患者的Everolimus昼夜节律药代动力学及有限采样策略研究
Yuka Terada,Kyoichi Wada,Sachi Matsuda et al.
Yuka Terada et al.
Objective: To evaluate circadian changes in everolimus (EVL) pharmacokinetics and to identify the time point of blood sampling with the strongest correlation with the area under the blood concentration-time curve (AUC) of...
Tolerability and safety of Octagam® (IVIG): a post-authorization safety analysis of four non-interventional phase IV trials [0.03%]
奥特伽（IVIG）的耐受性和安全性：四项非干预性IV期试验的上市后安全分析
Wolfgang Frenzel,Stefan Wietek,Tor-Einar Svae et al.
Wolfgang Frenzel et al.
Objective: To evaluate the tolerability and safety of Octagam® 5% and 10% across all indications, ages, and treatment regimens, using data from four non-interventional post-authorization safety studies (PASS); this analy...
Effect of food on the oral bioavailability of the angiotensin receptor - neprilysin inhibitor sacubitril/valsartan (LCZ696) in healthy subjects [0.03%]
高血压试剂在健康受试者中的生物利用度研究
Surya Ayalasomayajula,Thomas H Langenickel,Priya Chandra et al.
Surya Ayalasomayajula et al.
Objective: Sacubitril/valsartan (LCZ696) provides a novel therapeutic approach of neurohormonal modulation in heart failure via simultaneous inhibition of neprilysin and blockade of the angiotensin II type-1 receptor. Thi...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2016 Dec;54(12):1012-1018. DOI:10.5414/CP202604 2016
Blood lipid abnormality changes the rate of alveolar-capillary uptake of sevoflurane: a prospective, non-interventional, clinical study [0.03%]
血清脂质异常改变静脉吸入七氟烷肺泡-毛细血管摄取速率：前瞻性非干预性临床研究
YanQiu Liu,YiMin Ren,Hong Gao et al.
YanQiu Liu et al.
Objective: This research studied the influence of different blood lipid components on the rate of alveolar-capillary uptake of sevoflurane. Method: 104 patients aged 20 - 50 years undergoing elective operations under gene...
Evaluation of the safety, pharmacokinetics, pharmacodynamics, and drug-drug interaction potential of a selective Lp-PLA2 inhibitor (GSK2647544) in healthy volunteers [0.03%]
评估选择性Lp-PLA2抑制剂（GSK2647544）在健康志愿者中的安全性、药代动力学、药效学及药物相互作用潜力
Kai Wu,Jianfeng Xu,Regan Fong et al.
Kai Wu et al.
Objective: To evaluate in healthy volunteers the safety, pharmacokinetics (PK), pharmacodynamics (PD), and drug-drug interaction (DDI) potential of GSK2647544, (a selective lipoprotein-associated phospholipase A2 (Lp-PLA2...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2016 Dec;54(12):935-949. DOI:10.5414/CP202565 2016
Berberine promotes antiproliferative effects of epirubicin in T24 bladder cancer cells by enhancing apoptosis and cell cycle arrest [0.03%]
小檗碱通过促进凋亡和细胞周期阻滞增强表柔比星对T24膀胱癌细胞的抗增殖作用
Yumin Zhuo,Qibiao Chen,Bo Chen et al.
Yumin Zhuo et al.
Objective: The present study was aimed to observe the effect of berberine (Ber) on epirubicin (EPI)-induced growth inhibition, apoptosis, and cell cycle arrest in T24 bladder cancer cells. ...
Ocular safety of propiverine hydrochloride in elderly patients with primary open- and narrow-angle glaucoma [0.03%]
盐酸丙派氯林在老年原发性开角型和窄角型青光眼患者中的眼部安全性研究
Emil Gatchev,Natalia Petkova,Manfred Braeter et al.
Emil Gatchev et al.
Background: Propiverine hydrochloride (P4) is an antimuscarinic drug used in overactive bladder syndrome. Methods: Two studies were per...
Randomized Controlled Trial
International journal of clinical pharmacology and therapeutics. 2016 Dec;54(12):977-986. DOI:10.5414/CP202638 2016
Evaluation of a novel autoinjector for subcutaneous self-administration of belimumab in systemic lupus erythematosus [0.03%]
评估新型自动注射器皮下给药用于系统性红斑狼疮患者的贝利木单抗自治疗的效果
Saira Z Sheikh,Anne E Hammer,Norma Lynn Fox et al.
Saira Z Sheikh et al.
Objective: To study self-administration and pharmacokinetics (PK) of subcutaneous (SC) belimumab in patients with systemic lupus erythematosus (SLE). Meth...