Prediction of hyperkalemia occurrence in patients using co-trimoxazole: Clinical adjustment of a Markov model [0.03%]
使用Markov模型预测联合磺胺甲噁唑患者高钾血症的发生：临床调整
Fumiya Watanabe,Toshinori Hirai,Chihiro Shiraishi et al.
Fumiya Watanabe et al.
Objective: Predicting the occurrence of hyperkalemia in patients undergoing co-trimoxazole treatment for Pneumocystis pneumonia is critical. However, other factors besides drug exposure affect serum potassium levels, and ...
Cost-utility analysis of pembrolizumab versus nivolumab in the treatment of metastatic colorectal cancer from the perspective of the healthcare payer [0.03%]
从医疗支付方的角度分析派姆单抗与尼伏利尤单抗在转移性结直肠癌治疗中的成本效用
Zhen Lu,Xiaoyan Huang,Yingjuan Ou et al.
Zhen Lu et al.
Background: Colorectal cancer (CRC) is a malignant tumor with the third highest incidence worldwide. The comprehensive economic evaluation of programmed cell death protein-1 inhibitors in China, however, has not yet been ...
Alleviation of renal ischemia-reperfusion injury by quercetin, kaempferol, and myricetin in Shiwei Hezi pill (SHP): Network pharmacology and molecular docking analysis of a traditional Tibetan herbal agent [0.03%]
传统藏药石韦合子丸(SHP)中的槲皮素、山柰酚和我的 cetin 对肾缺血再灌注损伤的缓解作用：网络药理学与分子对接分析
Drolma Gomchok,Hui Yang,Tana Wuren
Drolma Gomchok
Objective: The aim of the study was to utilize a systematic network pharmacology approach to explore the active components, targets, and pathways associated with the efficacy of Shiwei Hezi pill (SHP) in treating renal is...
Differentiation of bone marrow mesenchymal stem cells modulated by Bushen Tian Sui decoction via the TGF-β1-Smad2/3 signaling pathway: In vitro evidence and potential clinical application in delayed fracture healing [0.03%]
补肾填髓汤通过TGF-β1-Smad2/3信号通路调节骨髓间充质干细胞分化的研究：体外证据及其在骨折愈合延迟中的潜在临床应用
Wei Xiong,Bingru Li,Jiamin Chen et al.
Wei Xiong et al.
Background: Bone-related disorders pose significant challenges in clinical practice. Bone marrow mesenchymal stem cells (BMSCs), as multipotent stem cells, play a pivotal role in bone regeneration. The TGF-β1-Smad2/3 sig...
Bisphosphonates in combination with alendronate sodium increase bone mineral density and modulate IL-6, TNF-α, and IGF-1 in patients with osteoporosis [0.03%]
双膦酸盐与阿仑磷酸钠联用增加骨矿物密度并调节骨质疏松症患者IL-6、TNF-α和IGF-1的水平
Xuechun Gu,Liyuan Zhang,Xiangyi Chen et al.
Xuechun Gu et al.
Objective: To assess the effects of bisphosphonates (zoledronic acid injection) plus alendronate sodium on bone mineral density (BMD) and levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and insulin-like...
Evidence for a loss of analgesia when hydromorphone administered in combination with hange-shashin-to: Enterohepatic circulation and β-glucuronidase inhibition [0.03%]
证据显示当盐酸氢吗啡酮与汉蛇散联合使用时镇痛作用会减弱：肠肝循环和β-葡萄糖苷酶抑制
Masakazu Ozaki,Hiroshi Yamagata,Hiroto Matsui et al.
Masakazu Ozaki et al.
Network pharmacology and experimental analysis of Yudantong decoction, a multi-immunomodulator for the treatment of intractable cholestatic liver disease: Identification of active agents, molecular targets, and mechanisms of action [0.03%]
淤胆通方作为难治性胆汁淤积性肝病多靶免疫调节剂的网络药理及实验分析：活性成分、分子靶标和作用机制的鉴定
Xiaoming Wu,Linyi Hou,Jing Liu et al.
Xiaoming Wu et al.
Background: Yudantong decoction (YDTD) is a therapeutic prescription for cholestatic liver disease (CLD) and is clinically effective in our medical institution. However, the exact constituents and mechanisms of YDTD in tr...
Cardiovascular safety profile of JAK inhibitors and ethnic factors in Asians: A signal detection study using the Global ICSR (WHO-UMC VigBase) database [0.03%]
亚洲人JAK抑制剂的心血管安全性及种族因素的信号检测研究：来自世界卫生组织不良事件数据库(VigBase)的数据分析
Woongshik Nam,Ji-Hwan Bae,Jeongin Oh et al.
Woongshik Nam et al.
Objective: This study aimed to detect cardiovascular disease-related signals using Global Individual Case Safety Report data on JAK inhibitors. Materials ...
Niraparib-related severe refractory thrombocytopenia in ovarian cancer patients receiving paclitaxel/carboplatin chemotherapy: A report on three cases [0.03%]
尼拉帕利相关重度难治性血小板减少症在接受紫杉醇/卡铂化疗的卵巢癌患者中的临床观察：三例报告
Mingtao Chen,Lin Zhou,Huijuan Yang et al.
Mingtao Chen et al.
A characteristic toxicity of niraparib is a decrease in blood platelets (PLT), with an incidence of ~ 34% for grades 3 - 4 conditions. However, exceedingly severe cases have been reported infrequently. This paper describes three patients wi...
Longevity - via traditional Chinese medicine and macrobiotics to AI-driven network pharmacology and clinical pharmacology [0.03%]
长寿——从中医药和宏宜生观到人工智能驱动的网络药理学和临床药理学
Barrington G Woodcock-Kloberdanz
Barrington G Woodcock-Kloberdanz