Determination of antimicrobial resistance pattern among post-operative orthopedic implant patients in a tertiary care hospital: A retrospective study [0.03%]
一项三级护理医院骨科植入术后患者抗菌药物耐药性回顾性研究
Hajira Nazeer,Humaira Majeed Khan,Muhammad Abdul Hannan et al.
Hajira Nazeer et al.
Background: The misuse of antibiotics leads to antimicrobial resistance, particularly concerning infections related to orthopedic implants. The aim of this study was to determine the sensitivity pattern of bacterial isola...
Population pharmacokinetics of tofacitinib in patients with active ankylosing spondylitis [0.03%]
活性强直性脊柱炎患者托法替尼的群体药代动力学分析
Shinichi Tsuchiwata,Akiyuki Suzuki,Qiang Wang et al.
Shinichi Tsuchiwata et al.
Objective: To characterize tofacitinib pharmacokinetics (PK) in patients with active ankylosing spondylitis (AS) and estimate the effects of covariates on variability of PK parameters. ...
Comparison of vasopressin-first weaning versus norepinephrine-first weaning in critically ill patients [0.03%]
血管升压素首阶撤药与去甲肾上腺素首阶撤药在危重患者中比较研究
Maram Alshreef,Hanin AbaAlkhayl,Qoot Almdainy et al.
Maram Alshreef et al.
Background: Septic shock is a critical condition requiring vasopressor support and mechanical ventilation. The sequence of vasopressor weaning may affect clinical outcomes, such as mechanical ventilation duration and pati...
Adverse reactions of PD-1/PD-L1 inhibitors in cancer: FEARS database analysis and protocols to mitigate immune-related events in elderly patients and when using pembrolizumab and atezolizumab [0.03%]
PD-1/PD-L1抑制剂在癌症治疗中的不良反应：FEARS数据库分析及老年患者治疗中和使用帕博利珠单抗和阿特朱单抗时减轻免疫相关事件的方案
Saizhu He,Jingyi Chen,Liming Gu et al.
Saizhu He et al.
Objective: This study aimed to characterize adverse drug reactions (ADRs) associated with programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) inhibitors in cancer immunotherapy, identifying demographic, pharmacologi...
Effect of extracorporeal anticoagulation with nafamostat mesilate and continuous renal replacement therapy on sepsis complicated with acute kidney injury [0.03%]
纳法alk基硫酸酯体体外抗凝结合连续性肾脏替代治疗联合血必净对脓毒症并发急性肾损伤的影响
Jianfeng Zhang,Hongyi Shao,Dong Zhu et al.
Jianfeng Zhang et al.
Objective: We aimed to evaluate the effect of extracorporeal anticoagulation with nafamostat mesilate (NM) and continuous renal replacement therapy (CRRT) on sepsis complicated with acute kidney injury (AKI). ...
Pegylated liposomal doxorubicin-induced hand-foot syndrome in a patient with breast cancer: Case report and FAERS database analysis [0.03%]
乳腺癌患者使用多西他赛引起的手足综合症：病例报告及FAERS数据库分析
Kejun Qu,Jialan Zhao,Yongli Zhang et al.
Kejun Qu et al.
Hand-foot syndrome (HFS) is a relatively common, dose-limiting dermatologic toxic reaction associated with multiple chemotherapeutic agents, including pegylated liposomal doxorubicin (PLD). Early symptoms of HFS include erythema, marked dis...
Barrington G Woodcock-Kloberdanz
Barrington G Woodcock-Kloberdanz
Entecavir HPLC-MS/MS quantitation and optimized sample preparation using human plasma: Validation in a pharmacokinetic study [0.03%]
恩替卡韦HPLC-MS/MS定量和人血浆中优化样品制备：在药代动力学研究中的验证方法论研究
Rui Zhao,Pengfei Li,Hongchuan Liu et al.
Rui Zhao et al.
Aims: To determine the entecavir levels in human plasma using a quantitative high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) technique. ...
Analysis of the clinical characteristics and risk factors for dabigatran-induced bleeding in patients with nonvalvular atrial fibrillation [0.03%]
达比加群所致非瓣膜性房颤患者出血的临床特征和危险因素分析
Xiaojuan Wang,Xiaoying Wang,Ya Li et al.
Xiaojuan Wang et al.
Objective: To explore the clinical characteristics of dabigatran-induced bleeding and analyze its risk factors in patients with nonvalvular atrial fibrillation (NVAF). ...
Association between incretin-related drugs and fractures in patients treated with pioglitazone: A pharmacovigilance study using the FDA Adverse Event Reporting System [0.03%]
基于美国食品药品监督管理局不良事件报告系统的药物警戒研究：胰高血糖素样肽-1分泌促进剂及二肽基肽酶-4抑制剂与曲格列酮使用者骨折风险关联性分析
Katsuhiro Ohyama,Nonoka Abe,Takumi Okamoto et al.
Katsuhiro Ohyama et al.
Objective: Diabetes mellitus (DM) causes various long-term complications and has, e.g., a direct negative effect on bone metabolism. Pioglitazone, which is used to treat DM, increases the risk of fractures. Reduced bone m...