Skin toxicity associated with immune checkpoint inhibitors based on the FDA adverse event reporting system 2011 - 2023 data [0.03%]
基于FDA不良事件报告系统(2011-2023年)的免疫检查点抑制剂相关皮肤毒性分析
Xiao-Yan Qiu,Zhang-Yong Fu,Ai-Feng Wu
Xiao-Yan Qiu
Purpose: To evaluate skin toxicity associated with immune checkpoint inhibitors (ICIs) using data mining and the U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS). ...
Cardiovascular toxicity associated with sedative drug use: Post-market pharmacovigilance study with disproportionality analysis [0.03%]
镇静药使用相关的心血管毒性：一项关于药物上市后再评价的研究及二项性分析
Pei Ye,Hewei Zhang,Qiang Lyu et al.
Pei Ye et al.
Objective: To compare the toxicity of sedatives in critically ill intensive care unit patients and investigate safety concerns using the United States Food and Drug Administration Adverse Event Reporting System and VigiBa...
Risk factors for severe neutropenia in patients with cytomegalovirus infection treated with ganciclovir: A retrospective observational study [0.03%]
更昔洛韦治疗巨细胞病毒感染患者严重中性粒细胞减少的风险因素：一项回顾性观察研究
Naoto Kimura,Ryosuke Ota,Atsushi Hirata
Naoto Kimura
Objective: This study aimed to investigate the baseline neutrophil count as a risk factor for ganciclovir-induced neutropenia in greater detail. Materials...
Bioequivalence of tamsulosin 0.4 mg film-coated sustained-release tablet formulations in healthy subjects under fasting conditions [0.03%]
空腹健康受试者中盐酸坦索罗辛0.4mg薄膜衣缓释片的生物等效性研究
Raymond R Tjandrawinata,Danang Agung Yunaidi,Yantirta Indra Kurniawan et al.
Raymond R Tjandrawinata et al.
This open-label, randomized, single-dose, 4-period, 2-sequence, fully replicated study was conducted to evaluate the bioequivalence of tamsulosin 0.4 mg sustained-release film-coated tablet manufactured by PT Dexa Medica, Indonesia, and Har...
Treatment of delirium in intensive care patients with sepsis using daily intravenous infusions with omega-3 fatty acids [0.03%]
每日静脉注射ω-3脂肪酸治疗脓毒症重症监护患者谵妄
De-Qiang Wang,Fang-Bao Hu,Wen Wang et al.
De-Qiang Wang et al.
Background: The development of delirium is closely linked to inflammatory processes. Omega-3 fatty acids can modulate the immune response and may contribute to reducing the incidence of sepsis-associated delirium (SAD). ...
Neurodegenerative protection with Orgaheal medium-chain triglycerides oil: Evidence from cell cultures, enzyme inhibition studies, and measurement of antioxidant and lipid-lowering properties [0.03%]
Orgaheal中链三酸甘油酯油的神经退行性保护作用：来自细胞培养、酶抑制研究和抗氧化及降脂作用测定的证据
Rajendran Aanaimuthu,Sudesh Raj Rajendran,Tejas Mudharaikal et al.
Rajendran Aanaimuthu et al.
Neurodegenerative diseases such as Alzheimer's and Parkinson's are marked by neuronal loss due to oxidative stress, neuro inflammation, and lipid dysregulation. Medium-chain triglyceride (MCT) oil, particularly rich in caprylic acid (C8, 56...
Primary hypertension in German children and adolescents: Low treatment rates and dominance of ACE inhibitors in an analysis of 7,482 cases for the period 2005 to 2023 [0.03%]
德国儿童和青少年原发性高血压的低治疗率及血管紧张素转换酶抑制剂占主导地位：2005年至2023年7482例分析
Jacob Christian Moll,Jens Bohlken,Kerstin Weber et al.
Jacob Christian Moll et al.
Aims: To investigate prescription patterns in children and adolescents receiving treatment for primary hypertension. Materials and methods: ...
Cabotegravir pharmacokinetics in Asian population with and without HIV [0.03%]
卡博特格拉韦在亚洲人群中的药代动力学特点（有和没有HIV）
Kelong Han,Ahmed A Abulfathi,Rashmi S Mehta et al.
Kelong Han et al.
Objective: Cabotegravir is approved for HIV treatment (with rilpivirine) and prevention. The established cabotegravir population pharmacokinetic (PPK) model included 1.2% Asian participants. We aimed to compare cabotegrav...
Anti-neurodegenerative treatment in Alzheimer's disease: Multifaceted mechanisms of action of berberine [0.03%]
小檗碱治疗阿尔茨海默病的抗神经退行作用及多靶点机制研究
Dandan Song,Congmin Zhang
Dandan Song
Background: Berberine, a traditional Chinese medicine, has demonstrated significant therapeutic influences in treating diabetes, obesity, and diarrhea, among other conditions. It has exhibited potential therapeutic benefi...
Bioequivalence of two doxorubicin liposome formulations (LY01612 and Caelyx) using free and encapsulated doxorubicin concentrations in Chinese patients with advanced breast cancer [0.03%]
盐酸多柔比星脂质体注射液(里葆多和凯素)在中国晚期乳腺癌患者中生物等效性的药代动力学研究：游离及包封多柔比星浓度比较
Lina Zhang,Cuizhi Geng,Mingxia Wang et al.
Lina Zhang et al.
Objective: To determine the pharmacokinetic properties and bioequivalence of a reference doxorubicin injectable formulation (Caelyx) and the test formulation, a newly developed doxorubicin hydrochloride liposome injection...